ArticleBMC systems biology2013
A 3D multiscale model of cancer stem cell in tumor development.
Article in BMC systems biology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 28 citations in OpenAlex.
- A hybrid multiscale model for predicting CAR-T therapy outcomes in solid tumors.Scientific reports · 2026Article
- The Optimal Tetralogy of Fallot Repair Using Generative Adversarial Networks.Frontiers in physiology · 2021Article
- Role of cancer stem cells in the development of giant cell tumor of bone.Cancer cell international · 2020Review
- Implications of HIF-1α in the tumorigenesis and progression of pancreatic cancer.Cancer cell international · 2020Review
- Three-dimensional tumor growth in time-varying chemical fields: a modeling framework and theoretical study.BMC bioinformatics · 2019Article
- Multiscale Tumor Modeling With Drug Pharmacokinetic and Pharmacodynamic Profile Using Stochastic Hybrid System.Cancer informatics · 2018Review
- A systems biology approach to studying the molecular mechanisms of osteoblastic differentiation under cytokine combination treatment.NPJ Regenerative medicine · 2017Article
- Intraglomerular crosstalk elaborately regulates podocyte injury and repair in diabetic patients: insights from a 3D multiscale modeling study.Oncotarget · 2016Article
- Microfluidics 3D gel-island chip for single cell isolation and lineage-dependent drug responses study.Lab on a chip · 2016Article
- In silico study of the impact of cancer stem cell dynamics and radiobiological hypoxia on tumour response to hyperfractionated radiotherapy.Cell proliferation · 2016Article
- Cancer Stem Cell Plasticity as Tumor Growth Promoter and Catalyst of Population Collapse.Stem cells international · 2016Article
- Computational systems biology in cancer brain metastasis.Frontiers in bioscience (Scholar edition) · 2016Review
- Toward a science of tumor forecasting for clinical oncology.Cancer research · 2015Review
- Silibinin strongly inhibits the growth kinetics of colon cancer stem cell-enriched spheroids by modulating interleukin 4/6-mediated survival signals.Oncotarget · 2014Article
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 2 countries.
Funding
Abstract
backgroundRecent reports indicate that a subgroup of tumor cells named cancer stem cells (CSCs) or tumor initiating cells (TICs) are responsible for tumor initiation, growth and drug resistance. This subgroup of tumor cells has self-renewal capacity and could differentiate into heterogeneous tumor cell populations through asymmetric proliferation. The idea of CSC provides informative insights into tumor initiation, metastasis and treatment. However, the underlying mechanisms of CSCs regulating tumor behaviors are unclear due to the complex cancer system. To study the functions of CSCs in the complex tumor system, a few mathematical modeling studies have been proposed. Whereas, the effect of microenvironment (mE) factors, the behaviors of CSCs, progenitor tumor cells (PCs) and differentiated tumor cells (TCs), and the impact of CSC fraction and signaling heterogeneity, are not adequately explored yet.
methodsIn this study, a novel 3D multi-scale mathematical modeling is proposed to investigate the behaviors of CSCsin tumor progressions. The model integrates CSCs, PCs, and TCs together with a few essential mE factors. With this model, we simulated and investigated the tumor development and drug response under different CSC content and heterogeneity.
resultsThe simulation results shown that the fraction of CSCs plays a critical role in driving the tumor progression and drug resistance. It is also showed that the pure chemo-drug treatment was not a successful treatment, as it resulted in a significant increase of the CSC fraction. It further shown that the self-renew heterogeneity of the initial CSC population is a cause of the heterogeneity of the derived tumors in terms of the CSC fraction and response to drug treatments.
conclusionsThe proposed 3D multi-scale model provides a new tool for investigating the behaviors of CSC in CSC-initiated tumors, which enables scientists to investigate and generate testable hypotheses about CSCs in tumor development and drug response under different microenvironments and drug perturbations.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.