ReviewStem cell research & therapy2013
Innovations in preclinical biology: ex vivo engineering of a human kidney tissue microperfusion system.
Review in Stem cell research & therapy, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 35 citations in OpenAlex.
- Sustained alterations in proximal tubule gene expression in primary culture associate with HNF4A loss.Scientific reports · 2024Article
- Functional Drug Screening using Kidney Cells On-A-Chip: Advances in Disease Modeling and Development of Biomarkers.Kidney360 · 2022Article
- Microphysiological systems in absorption, distribution, metabolism, and elimination sciences.Clinical and translational science · 2022Review
- Organ-on-chip applications in drug discovery: an end user perspective.Biochemical Society transactions · 2021Review
- A Novel Fluorogenic Assay for the Detection of Nephrotoxin-Induced Oxidative Stress in Live Cells and Renal Tissue.ACS sensors · 2021Article
- Tissue Chips in Space-Challenges and Opportunities.Clinical and translational science · 2020Article
- A glomerulus-on-a-chip to recapitulate the human glomerular filtration barrier.Nature communications · 2019Article
- Emerging Role of Organ-on-a-Chip Technologies in Quantitative Clinical Pharmacology Evaluation.Clinical and translational science · 2019Review
- Microfluidic-Based 3D Engineered Microvascular Networks and Their Applications in Vascularized Microtumor Models.Micromachines · 2018Review
- Advances in predictive in vitro models of drug-induced nephrotoxicity.Nature reviews. Nephrology · 2018Review
- Inhibition ofJournal of the American Society of Nephrology : JASN · 2017Article
- Article
- Microfabricated Physiological Models for In Vitro Drug Screening Applications.Micromachines · 2016Review
- Abundance of Drug Transporters in the Human Kidney Cortex as Quantified by Quantitative Targeted Proteomics.Drug metabolism and disposition: the biological fate of chemicals · 2016Article
- Liver and Kidney on Chips: Microphysiological Models to Understand Transporter Function.Clinical pharmacology and therapeutics · 2016Review
- Development of a microphysiological model of human kidney proximal tubule function.Kidney international · 2016Article
- Physiologically relevant human tissue models for infectious diseases.Drug discovery today · 2016Review
- A Quantitative Approach to Screen for Nephrotoxic Compounds In Vitro.Journal of the American Society of Nephrology : JASN · 2016Article
- Tissue-engineered microenvironment systems for modeling human vasculature.Experimental biology and medicine (Maywood, N.J.) · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
17 authors at 3 institutions in 1 country.
Funding
Abstract
Kidney disease is a public health problem that affects more than 20 million people in the US adult population, yet little is understood about the impact of kidney disease on drug disposition. Consequently there is a critical need to be able to model the human kidney and other organ systems, to improve our understanding of drug efficacy, safety, and toxicity, especially during drug development. The kidneys in general, and the proximal tubule specifically, play a central role in the elimination of xenobiotics. With recent advances in molecular investigation, considerable information has been gathered regarding the substrate profiles of the individual transporters expressed in the proximal tubule. However, we have little knowledge of how these transporters coupled with intracellular enzymes and influenced by metabolic pathways form an efficient secretory and reabsorptive mechanism in the renal tubule. Proximal tubular secretion and reabsorption of xenobiotics is critically dependent on interactions with peritubular capillaries and the interstitium. We plan to robustly model the human kidney tubule interstitium, utilizing an ex vivo three-dimensional modular microphysiological system with human kidney-derived cells. The microphysiological system should accurately reflect human physiology, be usable to predict renal handling of xenobiotics, and should assess mechanisms of kidney injury, and the biological response to injury, from endogenous and exogenous intoxicants.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.