Evidence map›Paper›PMID 24564800›Full record

SynthesisBMC public health2013

The associations of parity and maternal age with small-for-gestational-age, preterm, and neonatal and infant mortality: a meta-analysis.

Naoko Kozuki, Anne C C Lee, Mariangela F Silveira, Ayesha Sania, Joshua P Vogel, Linda Adair, Fernando Barros, Laura E Caulfield, Parul Christian, Wafaie Fawzi and 11 more

Abstract readMeta-Analysis
In one paragraph

Synthesis in BMC public health, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 156 papers, 9 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
156citing papers in PubMed, 9 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

156 citing papers in PubMed, 9 syntheses or guidelines pooled it.

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  13. Right-sizing Incentives.Journal of development economics · 2026
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96 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors.

Naoko Kozuki
Anne C C Lee
Mariangela F Silveira
Ayesha Sania
Joshua P Vogel
Linda Adair
Fernando Barros
Laura E Caulfield
Parul Christian
Wafaie Fawzi
Jean Humphrey
Lieven Huybregts
Aroonsri Mongkolchati
Robert Ntozini
David Osrin
Dominique Roberfroid
James Tielsch
Anjana Vaidya
Robert E Black
Joanne Katz
Child Health Epidemiology Reference Group Small-for-Gestational-Age-Preterm Birth Working Group

Funding

Carolina Population CenterR24HD050924 · NICHD · UNIV OF NORTH CAROLINA CHAPEL HILL · PI MORGAN, SAMUEL PHILIP · 2005 to 2014
$10.0M
NICHD NIH HHS R24 HD050924Wellcome Trust 091561Wellcome Trust 100714
6 · The paper itself

Abstract

backgroundPrevious studies have reported on adverse neonatal outcomes associated with parity and maternal age. Many of these studies have relied on cross-sectional data, from which drawing causal inference is complex. We explore the associations between parity/maternal age and adverse neonatal outcomes using data from cohort studies conducted in low- and middle-income countries (LMIC).

methodsData from 14 cohort studies were included. Parity (nulliparous, parity 1-2, parity ≥ 3) and maternal age (<18 years, 18-<35 years, ≥ 35 years) categories were matched with each other to create exposure categories, with those who are parity 1-2 and age 18-<35 years as the reference. Outcomes included small-for-gestational-age (SGA), preterm, neonatal and infant mortality. Adjusted odds ratios (aOR) were calculated per study and meta-analyzed.

resultsNulliparous, age <18 year women, compared with women who were parity 1-2 and age 18-<35 years had the highest odds of SGA (pooled adjusted OR: 1.80), preterm (pooled aOR: 1.52), neonatal mortality (pooled aOR: 2.07), and infant mortality (pooled aOR: 1.49). Increased odds were also noted for SGA and neonatal mortality for nulliparous/age 18-<35 years, preterm, neonatal, and infant mortality for parity ≥ 3/age 18-<35 years, and preterm and neonatal mortality for parity ≥ 3/≥ 35 years.

conclusionsNulliparous women <18 years of age have the highest odds of adverse neonatal outcomes. Family planning has traditionally been the least successful in addressing young age as a risk factor; a renewed focus must be placed on finding effective interventions that delay age at first birth. Higher odds of adverse outcomes are also seen among parity ≥ 3 / age ≥ 35 mothers, suggesting that reproductive health interventions need to address the entirety of a woman's reproductive period.

fundingFunding was provided by the Bill & Melinda Gates Foundation (810-2054) by a grant to the US Fund for UNICEF to support the activities of the Child Health Epidemiology Reference Group.

Indexed as

Infant, Small for Gestational AgeMaternal AgeParityAdultCohort StudiesCross-Sectional StudiesFemaleHumansInfantInfant DeathInfant MortalityInfant, NewbornOdds RatioPregnancyPremature BirthPrevalence

Identifiers

PMID24564800
PMCPMC3847520

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.