ArticleBMC bioinformatics2014
Towards integrative gene functional similarity measurement.
Article in BMC bioinformatics, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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7 citing papers in PubMed.
- Identifying Alzheimer's disease-related proteins by LRRGD.BMC bioinformatics · 2019Article
- Improving the measurement of semantic similarity by combining gene ontology and co-functional network: a random walk based approach.BMC systems biology · 2018Article
- Investigations on factors influencing HPO-based semantic similarity calculation.Journal of biomedical semantics · 2017Article
- Predicting disease-related genes using integrated biomedical networks.BMC genomics · 2017Article
- InteGO2: a web tool for measuring and visualizing gene semantic similarities using Gene Ontology.BMC genomics · 2016Article
- Missing value imputation for microRNA expression data by using a GO-based similarity measure.BMC bioinformatics · 2016Article
- An integrative approach for measuring semantic similarities using gene ontology.BMC systems biology · 2014Article
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3 authors.
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Abstract
backgroundIn Gene Ontology, the "Molecular Function" (MF) categorization is a widely used knowledge framework for gene function comparison and prediction. Its structure and annotation provide a convenient way to compare gene functional similarities at the molecular level. The existing gene similarity measures, however, solely rely on one or few aspects of MF without utilizing all the rich information available including structure, annotation, common terms, lowest common parents.
resultsWe introduce a rank-based gene semantic similarity measure called InteGO by synergistically integrating the state-of-the-art gene-to-gene similarity measures. By integrating three GO based seed measures, InteGO significantly improves the performance by about two-fold in all the three species studied (yeast, Arabidopsis and human).
conclusionsInteGO is a systematic and novel method to study gene functional associations. The software and description are available at http://www.msu.edu/~jinchen/InteGO.
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