ArticleCommunicative & integrative biology2013
Temperature and excitable cells: Testable predictions from a thermodynamic perspective.
Article in Communicative & integrative biology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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1 citing paper in PubMed, 4 citations in OpenAlex.
- Pattern Formation in a Spatially Extended Model of Pacemaker Dynamics in Smooth Muscle Cells.Bulletin of mathematical biology · 2022Article
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2 authors at 2 institutions in 2 countries.
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Abstract
Temperature affects a host of biological processes, one of which is the conduction velocity of action potentials (AP). The velocity-temperature profile of APs has remained remarkably conserved across excitable animal and plant cells. Herein, we will not analyze this behavior in terms of temperature sensitivities of single molecules (e.g., ion channels), but rather we present a phenomenological thermodynamic interpretation. By assuming that APs are acoustic phenomena, one arrives at testable predictions about the temperature-dependence of the macroscopic material properties of the excitable cell membrane. These material properties set constraints on the excitability of a cell membrane and allow us to hypothesize about its typical relaxation timescales. The presented approach-by virtue of its thermodynamic nature-is by no means limited to temperature. It applies equally well to all thermodynamic variables (e.g., mechanical stretch, pH, ion concentrations, etc.) and to underline this argument we discuss some implications and predictions for sensory physiology.
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