Evidence map›Paper›PMID 24563668›Full record

ArticleJournal of Cancer2014

Evaluation of antioxidant and antiangiogenic properties of caesalpinia echinata extracts.

Elisangela Christhianne Barbosa da Silva Gomes, George Chaves Jimenez, Luis Claudio Nascimento da Silva, Fabrício Bezerra de Sá, Karen Pena Cavalcanti de Souza, Gerson S Paiva, Ivone Antônia de Souza

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of Cancer, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.7field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 17 citations in OpenAlex.

  1. Antiseptic effect of sea cucumber (Experimental and therapeutic medicine · 2016
    Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Elisangela Christhianne Barbosa da Silva Gomes1. Departamento de Farmácia, Universidade Federal de Pernambuco. Avenida Professor Moraes Rêgo, s/n Cidade Universitária, Recife, PE, 50670-420 Pernambuco, Brasil.
George Chaves Jimenez2. Departamento de morfologia e fisiologia animal, Universidade Federal Rural de Pernambuco. Rua Dom Manoel de Medeiros, S/N, Dois Irmãos, Recife, PE, 52171-900 Pernambuco, Brasil.
Luis Claudio Nascimento da Silva3. Departamento de Bioquímica, Universidade Federal de Pernambuco. Avenida Professor Moraes Rêgo, s/n Cidade Universitária, Recife, PE, 50670-420 Pernambuco, Brasil.
Fabrício Bezerra de Sá4. Departamento de morfologia e fisiologia animal, Universidade Federal Rural de Pernambuco. Rua Dom Manoel de Medeiros, S/N, Dois Irmãos, Recife, PE, 52171-900 Pernambuco, Brasil.
Karen Pena Cavalcanti de Souza5. Departamento de imunopatologia Keiso Asami (LIKA), Federal de Pernambuco. Avenida Professor Moraes Rêgo, s/n Cidade Universitária, Recife, PE, 50670-420 Pernambuco, Brasil.
Gerson S Paiva6. Centro Brasileiro de Pesquisas Físicas, Rua Dr. Xavier Sigaud, 150, Urca, RJ, 22290-180 Rio de Janeiro, Brasil.
Ivone Antônia de Souza7. Departamento de Farmácia, Universidade Federal de Pernambuco. Avenida Professor Moraes Rêgo, s/n Cidade Universitária, Recife, PE, 50670-420 Pernambuco, Brasil.
Universidade Federal de Pernambuco · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Natural products contain important combinations of ingredients, which may to some extent help to modulate the effects produced by oxidation substrates in biological systems. It is known that substances capable of modulating the action of these oxidants on tissue may be important allies in the control of neovascularization in pathological processes. The aim of this study was to evaluate the antioxidant and antiangiogenic properties of an ethanol extract of Caesalpinia echinata. The evaluation of antioxidant properties was tested using two methods (DPPH inhibition and sequestration of nitric oxide). The antiangiogenic properties were evaluated using the inflammatory angiogenesis model in the corneas of rats. The extract of C. echinata demonstrated a high capacity to inhibit free radicals, with IC50 equal to 42.404 µg/mL for the DPPH test and 234.2 µg/mL for nitric oxide. Moreover, it showed itself capable of inhibiting the inflammatory angiogenic response by 77.49%. These data suggest that biochemical components belonging to the extract of C. echinata interfere in mechanisms that control the angiogenic process, mediated by substrates belonging to the arachidonic acid cascade, although the data described above also suggest that the NO buffer may contribute to some extent to the reduction in the angiogenic response.

Indexed as

angiogenesisantioxidantCaesalpinia echinatanatural products

Identifiers

PMID24563668
PMCPMC3930905
OpenAlexW2148975156

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.