ArticleInternational journal of dentistry2014
The effect of hydroxyapatite nanocrystals on osseointegration of titanium implants: an in vivo rabbit study.
Article in International journal of dentistry, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
13 citing papers in PubMed.
- Article
- Advances of Hydroxyapatite Nanoparticles in Dental Implant Applications.International dental journal · 2025Review
- Prosthetic Joint Infection Research Models in NZW Rabbits: Opportunities for Standardization-A Systematic Review.Journal of functional biomaterials · 2024Review
- Tribocorrosion of 3D printed dental implants: An overview.Journal of Taibah University Medical Sciences · 2024Review
- Nanohydroxyapatite in dentistry: A comprehensive review.The Saudi dental journal · 2023Article
- Osteocytes Influence on Bone Matrix Integrity Affects Biomechanical Competence at Bone-Implant Interface of Bioactive-Coated Titanium Implants in Rat Tibiae.International journal of molecular sciences · 2021Article
- Review on material parameters to enhance bone cell function in vitro and in vivo.Biochemical Society transactions · 2020Review
- 3-dimensional visualization of implant-tissue interface with the polyethylene glycol associated solvent system tissue clearing method.Cell proliferation · 2019Article
- Sol-gel based calcium phosphates coatings deposited on binary Ti-Mo alloys modified by laser beam irradiation for biomaterial/clinical applications.Journal of materials science. Materials in medicine · 2018Article
- Osseointegration of standard and mini dental implants: a histomorphometric comparison.International journal of implant dentistry · 2017Article
- Nano-Hydroxyapatite Stimulation of Gene Expression Requires Fgf Receptor, Phosphate Transporter, and Erk1/2 Signaling.ACS applied materials & interfaces · 2017Article
- Cytotoxicity Evaluation of High-Temperature Annealed Nanohydroxyapatite in Contact with Fibroblast Cells.Materials (Basel, Switzerland) · 2017Article
- Biological characterization of a new silicon based coating developed for dental implants.Journal of materials science. Materials in medicine · 2016Article
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Osseointegration is dependent on implant surface characteristics, including surface chemistry and topography. The presence of nanosized calcium phosphates on the implant surface is interesting to investigate since they affect both the nanotopography and surface chemistry, forming a bone mineral resembling surface. In this work, the osseointegration of titanium implants with and without the presence of hydroxyapatite (HA) nanocrystals has been evaluated in vivo. The integration was examined using removal torque measurements and real-time polymerase chain reaction (RT-PCR) analysis. The study was performed using two healing time points, 3 and 12 weeks. The results showed that the torque needed to remove the implants was insignificant between the non- and HA-coated implants, both at weeks 3 and 12. The RT-PCR, however, showed significant differences for osteoblast, osteoclast, and proinflammation markers when HA nanocrystals were present.
Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.