ArticleJournal of young pharmacists : JYP2013
Synthesis, characterisation and evaluation of N-mannich bases of 2-substituted Benzimidazole derivatives.
Article in Journal of young pharmacists : JYP, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed, 16 citations in OpenAlex.
- Dual inhibition of cell cycle progression and apoptotic resistance in breast cancer by novel benzimidazole-based therapeutics.Naunyn-Schmiedeberg's archives of pharmacology · 2026Article
- Synthesis, density functional theory study and in vitro antimicrobial evaluation of new benzimidazole Mannich bases.BMC chemistry · 2020Article
- Pharmacological and Toxicological Screening of Novel Benzimidazole-Morpholine Derivatives as Dual-Acting Inhibitors.Molecules (Basel, Switzerland) · 2017Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
rationaleBenzimidazoles and its derivatives represent one of the mainly biological active classes of literature.
aimIn this present study aimed to synthesize N-mannich bases derivatives compounds bearing of 2-substituted benzimidazole moiety, in order to investigate their possible biological activity.
methodBenzimidazole compounds were prepared from the condensation reaction between ortho phenylene diamine and various acids. Mannich base of newly synthesized Benzimidazole derivatives were synthesized from 2-substituted Benzimidazoles by reacting with secondary amines. The purity of the compounds was ascertained by melting point (m.p) and thin layer chromatography (TLC). Structures of the synthesized compounds were elucidated by spectral data. Antimicrobial assay was performed by microbroth dilution method. Bacterial genomic DNA cleavage was assessed by Agarose gel electrophoresis. Toxicity of the most effective compounds was studied by Brine-shrimp lethality assay.
resultAmong the synthesized compounds, compound 5E (a) and (b) was establish to be the most potent against all tested microorganisms. This two compounds exhibited complete bacterial DNA cleavage and non-toxic.
conclusionThese results suggest that it an interesting compound compared to the current therapeutic agents and are considered to investigate further for the same.
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