Evidence map›Paper›PMID 24563361›Full record

ReviewAdvances in experimental medicine and biology2014

Nuclear envelope in nuclear positioning and cell migration.

David Razafsky, Denis Wirtz, Didier Hodzic

Abstract readReview
In one paragraph

Review in Advances in experimental medicine and biology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed.

  1. Review
  2. The Nuclear Lamina.Cold Spring Harbor perspectives in biology · 2022
    Review
  3. Review
  4. Article
  5. Mislocalization of cone nuclei impairs cone function in mice.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2020
    Article
  6. Review
  7. Review
  8. Article
  9. Review
  10. Article
  11. Article
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

David RazafskyDepartment of Ophthalmology and Visual Sciences, Washington University School of Medicine, 660 South Euclid Ave, St. Louis, MO, 63110, USA, Razafsky@vision.wustl.edu.
Denis Wirtz
Didier Hodzic

Funding

WASHINGTON UNIVERSITY CENTER VISION RESEARCHP30EY002687 · NEI · WASHINGTON UNIVERSITY · PI Philip Andrew Ruzycki · 1985 to 2026
$18.4M
TRANS NETWORK PROJECTSU54CA143868 · NCI · JOHNS HOPKINS UNIVERSITY · PI WIRTZ, DENIS · 2009 to 2013
$13.7M
Research Training Program in the Vision SciencesT32EY013360 · NEI · WASHINGTON UNIVERSITY · PI SHIMING CHEN, Daniel Kerschensteiner · 2000 to 2026
$5.6M
Single-cell phenotyping for therapeutic stratification in pancreatic cancerR01CA174388 · NCI · JOHNS HOPKINS UNIVERSITY · PI WIRTZ, DENIS · 2012 to 2016
$3.8M
NUCLEAR DYNAMICS IN RETINAL DEVELOPMENT AND HOMEOSTASISR01EY022632 · NEI · WASHINGTON UNIVERSITY · PI HODZIC, DIDIER · 2013 to 2017
$1.9M
The nucleus-cytoskeleton connection in health and diseaseR01GM084204 · NIGMS · JOHNS HOPKINS UNIVERSITY · PI HODZIC, DIDIER, WIRTZ, DENIS · 2008 to 2011
$1.5M
NCI NIH HHS R01 CA174388NCI NIH HHS R01CA174388NCI NIH HHS U54 CA143868NCI NIH HHS U54CA143868NEI NIH HHS P30 EY002687NEI NIH HHS P30EY002687NEI NIH HHS R01 EY022632NEI NIH HHS R01EY022632NEI NIH HHS T32 EY013360NEI NIH HHS T32EY013360NIGMS NIH HHS R01GM08204NIGMS NIH HHS R01 GM084204
6 · The paper itself

Abstract

Hauling and anchoring the nucleus within immobile or motile cells, tissues, and/or syncytia represents a major challenge. In the past 15 years, Linkers of the Nucleoskeleton to the Cytoskeleton (LINC complexes) have emerged as evolutionary-conserved molecular devices that span the nuclear envelope and provide interacting interfaces for cytoskeletal networks and molecular motors to the nuclear envelope. Here, we review the molecular composition of LINC complexes and focus on how their genetic alteration in vivo has provided a wealth of information related to the relevance of nuclear positioning during tissue development and homeostasis with a special emphasis on the central nervous system. As it may be relevant for metastasis in a range of cancers, the involvement of LINC complexes in migration of nonneuronal cells via its interaction with the perinuclear actin cap will also be developed.

Indexed as

Cell AdhesionCell MovementHumansNuclear EnvelopeSingle-Cell Analysis

Identifiers

PMID24563361
PMCPMC4310828

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.