ArticleSleep & breathing = Schlaf & Atmung2014
Vascular adhesion molecules in men with obstructive sleep apnea: associations with obesity and metabolic syndrome.
Article in Sleep & breathing = Schlaf & Atmung, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
4 citing papers in PubMed, 1 synthesis or guideline pooled it, 9 citations in OpenAlex.
- Pooled it
- Polymorphonuclear neutrophils promote endothelial apoptosis by enhancing adhesion upon stimulation by intermittent hypoxia.Sleep & breathing = Schlaf & Atmung · 2022Article
- Obstructive sleep apnea is associated with lower adiponectin and higher cholesterol levels independently of traditional factors and other sleep disorders in middle-aged adults: the ELSA-Brasil cohort.Sleep & breathing = Schlaf & Atmung · 2021Article
- The impact of OSA and CPAP treatment on cell adhesion molecules' night-morning variation.Sleep & breathing = Schlaf & Atmung · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionMechanisms linking obstructive sleep apnea (OSA) to vascular diseases as well as obesity and metabolic syndrome are not clear. The purpose of the study was to evaluate levels of vascular adhesion molecules (soluble vascular cell adhesion molecules-1 (sVCAM-1) and E-selectin) in men with obstructive sleep apnea and control subjects and to determine their relations with obesity and metabolic syndrome.
methodsMen with OSA and controls matched for age were included in the study. Overnight polysomnography was performed. Body mass index (BMI) and all the components of metabolic syndrome were evaluated. Serum levels of sVCAM-1 and E-selectin were measured by enzyme-linked immunosorbent assay. Data presented as median (25th and 75th percentiles).
resultsLevels of sVCAM-1 (698.2 (627.6-798.2) vs 565.5 (518.8-678.1) ng/ml, p=0.003) and E-selectin (64.9 (50.1-83.1) vs 49.7 (39.8-59.5) ng/ml, p=0.017) were higher in the OSA group compared to the controls. Half of OSA patients had metabolic syndrome. Serum levels of sVCAM-1 and E-selectin did not differ in OSA patients with and without metabolic syndrome. Concentrations of both vascular adhesion molecules correlated with oxygen desaturation index (ODI), but the relation was no more significant after adjustment for all the components of metabolic syndrome. After adjustment for BMI, sVCAM-1 levels positively correlated with oxygen desaturation index (r=0.331, p=0.009).
conclusionsSerum levels of sVCAM-1 and E-selectin were increased in the OSA patient group compared to the controls. sVCAM-1 showed relation with ODI after adjustment for BMI suggesting that it could contribute to development of cardiovascular consequences in OSA patients.
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