ArticleInternational journal of hematology2014
Nov/CCN3 regulates long-term repopulating activity of murine hematopoietic stem cells via integrin αvβ3.
Article in International journal of hematology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
22 citing papers in PubMed, 28 citations in OpenAlex.
- Suppressing glutamate dehydrogenase guides hematopoietic stem cell divisions into self-renewal.Nature communications · 2026Article
- Proteomic profiling of the extracellular matrix in the human adrenal cortex.Matrix biology plus · 2024Article
- Fibroblast Growth Factors and Cellular Communication Network Factors: Intimate Interplay by the Founding Members in Cartilage.International journal of molecular sciences · 2022Review
- Molecular and Genetic Interactions between CCN2 and CCN3 behind Their Yin-Yang Collaboration.International journal of molecular sciences · 2022Review
- Recombinant expression a novel fibronectin-collage fusion peptide modulating stem cell stemness via integrin β3.Applied microbiology and biotechnology · 2022Article
- The extracellular matrix of hematopoietic stem cell niches.Advanced drug delivery reviews · 2022Review
- CCN2 (Cellular Communication Network factor 2) in the bone marrow microenvironment, normal and malignant hematopoiesis.Journal of cell communication and signaling · 2021Review
- Nov/CCN3 Enhances Cord Blood Engraftment by Rapidly Recruiting Latent Human Stem Cell Activity.Cell stem cell · 2020Article
- Inflammatory bone marrow microenvironment.Hematology. American Society of Hematology. Education Program · 2019Review
- Periostin function in communication with extracellular matrices.Journal of cell communication and signaling · 2018Review
- The Role of Interferon-Gamma in Hematopoietic Stem Cell Development, Homeostasis, and Disease.Current stem cell reports · 2018Review
- Introductory review: periostin-gene and protein structure.Cellular and molecular life sciences : CMLS · 2017Review
- The Regulatory Role of IFN-γ on the Proliferation and Differentiation of Hematopoietic Stem and Progenitor Cells.Stem cell reviews and reports · 2017Review
- Integrin αvβ3 enhances the suppressive effect of interferon-γ on hematopoietic stem cells.The EMBO journal · 2017Article
- Uterine responses to early pre-attachment embryos in the domestic dog and comparisons with other domestic animal species.Biology of reproduction · 2017Article
- Outside-in integrin signalling regulates haematopoietic stem cell function via Periostin-Itgav axis.Nature communications · 2016Article
- Aortic aneurysm, CCN3 may solve the problem.Journal of thoracic disease · 2016Article
- The role of the CCN family of proteins in blood cancers.Journal of cell communication and signaling · 2016Article
- The role of CCN family genes in haematological malignancies.Journal of cell communication and signaling · 2015Article
- Come together, right now….Journal of cell communication and signaling · 2015Article
Corrections and comments
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Authors and funding
10 authors at 5 institutions in 2 countries.
Funding
Abstract
Throughout life, hematopoietic stem cells (HSCs) sustain the blood cell supply through their capacities for self-renewal and multilineage differentiation. These processes are regulated within a specialized microenvironment termed the 'niche'. Here, we show a novel mechanism for regulating HSC function that is mediated by nephroblastoma overexpressed (Nov/CCN3), a matricellular protein member of the CCN family. We found that Nov contributes to the maintenance of long-term repopulating (LTR) activity through association with integrin αvβ3 on HSCs. The resultant β3 integrin outside-in signaling is dependent on thrombopoietin (TPO), a crucial cytokine involved in HSC maintenance. TPO was required for Nov binding to integrin αvβ3, and stimulated Nov expression in HSCs. However, in the presence of IFNγ, a cytokine known to impair HSC function, not only was TPO-induced expression of Nov suppressed, but the LTR activity was conversely impaired by TPO-mediated ligation of integrin αvβ3 with exogenous ligands, including Nov, as well. Thus, Nov/integrin αvβ3-mediated maintenance of HSCs appears to be modulated by simultaneous stimulation by other cytokines. Our finding suggests that this system contributes to the regulation of HSCs within the bone marrow niche.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.