ArticleJournal of bacteriology2014
Escherichia coli isolate for studying colonization of the mouse intestine and its application to two-component signaling knockouts.
Article in Journal of bacteriology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 55 papers.
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Who cites it
55 citing papers in PubMed.
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- An Escherichia coli Phosphotransferase System Modulates Methylglyoxal Resistance by Regulating Intracellular Potassium.Molecular microbiology · 2026Article
- Resident and EngraftingbioRxiv : the preprint server for biology · 2026Article
- Structural and functional insights into the Rcs phosphorelay.bioRxiv : the preprint server for biology · 2026Article
- Gut microbe-derivedProceedings of the National Academy of Sciences of the United States of America · 2026Article
- Transcriptomic profiling of a commensal Escherichia coli lysogen in simulated intestinal fluid reveals broad changes in both core and accessory regions of the genome.BMC genomics · 2026Article
- A phosphohistidine phosphatase promotes starvation survival by dephosphorylating nucleoside diphosphate kinase.Cell reports · 2026Article
- Bacteriophage Mu contamination impacts interbacterial competition.Infection and immunity · 2025Article
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- Escherichia coli phage-inducible chromosomal island aids helper phage replication and represses the locus of enterocyte effacement pathogenicity island.The ISME journal · 2025Article
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- Complete genome sequence ofMicrobiology resource announcements · 2024Article
- Dietary carbohydrates regulate intestinal colonization and dissemination of Klebsiella pneumoniae.The Journal of clinical investigation · 2024Article
- Role of themBio · 2023Article
- OmpC-Dependent Bile Tolerance Contributes to E. coli Colonization of the Mammalian Intestine.Microbiology spectrum · 2023Article
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- Two distinct gut microbial pathways contribute to meta-organismal production of phenylacetylglutamine with links to cardiovascular disease.Cell host & microbe · 2023Article
- Delivery of streptomycin to the rat colon by use of electrospun nanofibers.Scientific reports · 2022Article
Corrections and comments
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Authors and funding
9 authors.
Funding
Abstract
The biology of Escherichia coli in its primary niche, the animal intestinal tract, is remarkably unexplored. Studies with the streptomycin-treated mouse model have produced important insights into the metabolic requirements for Escherichia coli to colonize mice. However, we still know relatively little about the physiology of this bacterium growing in the complex environment of an intestine that is permissive for the growth of competing flora. We have developed a system for studying colonization using an E. coli strain, MP1, isolated from a mouse. MP1 is genetically tractable and does not require continuous antibiotic treatment for stable colonization. As an application of this system, we separately knocked out each two-component system response regulator in MP1 and performed competitions against the wild-type strain. We found that only three response regulators, ArcA, CpxR, and RcsB, produce strong colonization defects, suggesting that in addition to anaerobiosis, adaptation to cell envelope stress is a critical requirement for E. coli colonization of the mouse intestine. We also show that the response regulator OmpR, which had previously been hypothesized to be important for adaptation between in vivo and ex vivo environments, is not required for MP1 colonization due to the presence of a third major porin.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.