ArticleCancer causes & control : CCC2014
Total calcium intake and colorectal adenoma in young women.
Article in Cancer causes & control : CCC, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed, 13 citations in OpenAlex.
- Body mass index, calcium supplementation and risk of colorectal adenomas.International journal of cancer · 2019Trial
- Dairy intake during adolescence and risk of colorectal adenoma later in life.British journal of cancer · 2021Article
- Dietary Intake of Branched-Chain Amino Acids and Risk of Colorectal Cancer.Cancer prevention research (Philadelphia, Pa.) · 2020Article
- Associations of Calcium and Milk Product Intakes with Incident, Sporadic Colorectal Adenomas.Nutrition and cancer · 2017Article
- Low dairy calcium intake is associated with overweight and elevated blood pressure in Polish adults, notably in premenopausal women.Public health nutrition · 2017Article
- Nutrients, foods, and colorectal cancer prevention.Gastroenterology · 2015Review
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundTotal calcium intake appears to reduce occurrence of colorectal adenoma; however, the dose necessary for prevention in young women is unclear. We examined fine categories of calcium intake in relation to occurrence of first colorectal adenoma in a cohort of mostly premenopausal (88 %) women aged 26-60 at time of endoscopy.
designWe conducted an analysis among 41,403 participants in the Nurses' Health Study II and assessed intakes of calcium prior to endoscopy through participants' responses to biannual questionnaires.
resultsBetween 1991 and 2007, we documented 2,273 colorectal adenoma cases. There was a significant trend across categories of calcium intakes with lowest intakes suggestive of higher occurrence of adenoma (p = 0.03) and those in the distal colon (p = 0.03) and rectum (p = 0.04). Compared with 1,001-1,250 mg/day of calcium intake, ≤ 500 mg/day was suggestive of a modest increase in occurrence of adenoma (multivariable RR = 1.21, 95 % CI 0.90-1.61); there were also suggestions of an increased risk with >500 to ≤ 700 mg/day of calcium. The association between ≤ 500 mg/day of calcium intake and adenoma was stronger for multiple (RR = 2.27, 95 % CI 1.38, 3.72), large (≥ 1 cm) (RR = 2.01, 95 % CI 1.27, 3.21), and high-risk adenoma (≥ 1 cm or mention of villous histology/high-grade dysplasia) (RR = 1.76, 95 % CI 1.13, 2.72). No differences in associations were noted between jointly categorized calcium and phosphorus or magnesium intakes.
conclusionsOur findings suggest that low intakes of calcium, <500 and possibly 500-700 mg/day, in younger women are associated with an increased risk of multiple and advanced colorectal adenoma.
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