Evidence map›Paper›PMID 24562381›Full record

ArticleNature medicine2014

Dopamine mediates vagal modulation of the immune system by electroacupuncture.

Rafael Torres-Rosas, Ghassan Yehia, Geber Peña, Priya Mishra, Maria del Rocio Thompson-Bonilla, Mario Adán Moreno-Eutimio, Lourdes Andrea Arriaga-Pizano, Armando Isibasi, Luis Ulloa

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature medicine, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 348 papers, 12 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
348citing papers in PubMed, 12 pooled it
27.6field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

348 citing papers in PubMed, 12 syntheses or guidelines pooled it, 600 citations in OpenAlex.

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  6. Influence of acupuncture and moxibustion on gastrointestinal function and adverse events in gastric cancer patients after surgery and chemotherapy: a meta-analysis.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2024
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288 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 2 countries.

Rafael Torres-Rosas1] Laboratory of Anti-inflammatory Signaling, Department of Surgery, Rutgers University New Jersey Medical School, Newark, New Jersey, USA. [2] Medical Research Unit on Immunochemistry, National Medical Center Siglo XXI, Mexico City, Mexico.
Ghassan YehiaLaboratory of Anti-inflammatory Signaling, Department of Surgery, Rutgers University New Jersey Medical School, Newark, New Jersey, USA.
Geber PeñaLaboratory of Anti-inflammatory Signaling, Department of Surgery, Rutgers University New Jersey Medical School, Newark, New Jersey, USA.
Priya MishraLaboratory of Anti-inflammatory Signaling, Department of Surgery, Rutgers University New Jersey Medical School, Newark, New Jersey, USA.
Maria del Rocio Thompson-Bonilla1] Laboratory of Anti-inflammatory Signaling, Department of Surgery, Rutgers University New Jersey Medical School, Newark, New Jersey, USA. [2] The Institute for Social Security and Services for the State's Employees Research Institute, Mexico City, Mexico.
Mario Adán Moreno-EutimioLaboratory of Immunobiology, Hospital Juárez de México, Mexico City, Mexico.
Lourdes Andrea Arriaga-PizanoMedical Research Unit on Immunochemistry, National Medical Center Siglo XXI, Mexico City, Mexico.
Armando IsibasiMedical Research Unit on Immunochemistry, National Medical Center Siglo XXI, Mexico City, Mexico.
Luis Ulloa1] Laboratory of Anti-inflammatory Signaling, Department of Surgery, Rutgers University New Jersey Medical School, Newark, New Jersey, USA. [2] Center of Immunology and Inflammation, Rutgers University New Jersey Medical School, Newark, New Jersey, USA.
Rutgers, The State University of New Jersey · USCentro Medico Nacional Siglo XXI · MXRutgers New Jersey Medical SchoolHospital Juárez de México · MX

Funding

Cholinergic regulation of NF-kB in sepsisR01GM084125 · NIGMS · UNIV OF MED/DENT OF NJ-NJ MEDICAL SCHOOL · PI ULLOA, LUIS · 2008 to 2012
$1.5M
NIGMS NIH HHS R01 GM084125NIGMS NIH HHS R01-GM084125
6 · The paper itself

Abstract

Previous anti-inflammatory strategies against sepsis, a leading cause of death in hospitals, had limited efficacy in clinical trials, in part because they targeted single cytokines and the experimental models failed to mimic clinical settings. Neuronal networks represent physiological mechanisms, selected by evolution to control inflammation, that can be exploited for the treatment of inflammatory and infectious disorders. Here, we report that sciatic nerve activation with electroacupuncture controls systemic inflammation and rescues mice from polymicrobial peritonitis. Electroacupuncture at the sciatic nerve controls systemic inflammation by inducing vagal activation of aromatic L-amino acid decarboxylase, leading to the production of dopamine in the adrenal medulla. Experimental models with adrenolectomized mice mimic clinical adrenal insufficiency, increase the susceptibility to sepsis and prevent the anti-inflammatory effects of electroacupuncture. Dopamine inhibits cytokine production via dopamine type 1 (D1) receptors. D1 receptor agonists suppress systemic inflammation and rescue mice with adrenal insufficiency from polymicrobial peritonitis. Our results suggest a new anti-inflammatory mechanism mediated by the sciatic and vagus nerves that modulates the production of catecholamines in the adrenal glands. From a pharmacological perspective, the effects of selective dopamine agonists mimic the anti-inflammatory effects of electroacupuncture and can provide therapeutic advantages to control inflammation in infectious and inflammatory disorders.

Indexed as

Adrenal GlandsAnimalsCatecholaminesCytokinesDopa DecarboxylaseDopamineElectroacupunctureInflammationLipopolysaccharidesMaleMiceMice, Inbred C57BLNeuronsPeritonitisReceptors, Dopamine D1Sciatic NerveCatecholaminesCytokinesDopa DecarboxylaseDopamineLipopolysaccharidesReceptors, Dopamine D1

Identifiers

PMID24562381
PMCPMC3949155
OpenAlexW2151012511

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.