ArticleBrain structure & function2015
Individual differences in regional prefrontal gray matter morphometry and fractional anisotropy are associated with different constructs of executive function.
Article in Brain structure & function, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
41 citing papers in PubMed, 2 syntheses or guidelines pooled it, 81 citations in OpenAlex.
- Executive Function in High-Functioning Autism Spectrum Disorder: A Meta-analysis of fMRI Studies.Journal of autism and developmental disorders · 2020Pooled it
- The effects of acute stress on core executive functions: A meta-analysis and comparison with cortisol.Neuroscience and biobehavioral reviews · 2016Pooled it
- Brain-cognition relationships and treatment outcome in treatment-resistant late-life depression.Nature communications · 2026Article
- Timing and tempo of puberty and neurodevelopment following adversity: A registered report.Developmental cognitive neuroscience · 2026Article
- The Reassuring Absence of Acute Stress Effects on IQ Test Performance.Journal of Intelligence · 2025Article
- Connectome-Based Predictive Models of General and Specific Executive Functions.Human brain mapping · 2025Article
- Overwork and changes in brain structure: a pilot study.Occupational and environmental medicine · 2025Article
- Regional prefrontal and hippocampal differences in gray matter volume are linked to the propensity for renewal in extinction learning.Frontiers in behavioral neuroscience · 2025Article
- Executive function and underlying brain network distinctions for callous-unemotional traits and conduct problems in adolescents.bioRxiv : the preprint server for biology · 2023Article
- Connectivity by the Frontal Aslant Tract (FAT) Explains Local Functional Specialization of the Superior and Inferior Frontal Gyri in Humans When Choosing Predictive over Reactive Strategies: A Tractography-Guided TMS Study.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- Shared grey matter correlates of reading and attention.Brain and language · 2023Article
- Altered Functional Activity and Functional Connectivity of Seed Regions Based on ALFF Following Acupuncture Treatment in Patients with Stroke Sequelae with Unilateral Limb Numbness.Neuropsychiatric disease and treatment · 2023Article
- A cognitive neurogenetic approach to uncovering the structure of executive functions.Nature communications · 2022Article
- The role of prefrontal cortex in cognitive control and executive function.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2022Review
- Altered brain activity in end-stage knee osteoarthritis revealed by resting-state functional magnetic resonance imaging.Brain and behavior · 2022Article
- Neurocognitive factorial structure of executive functions: Evidence from neurotypicals and frontotemporal dementia.Cortex; a journal devoted to the study of the nervous system and behavior · 2021Article
- The effect of vascular health factors on white matter microstructure mediates age-related differences in executive function performance.Cortex; a journal devoted to the study of the nervous system and behavior · 2021Article
- Structural core of the executive control network: A high angular resolution diffusion MRI study.Human brain mapping · 2020Article
- Cortical morphometry and structural connectivity relate to executive function and estradiol level in healthy adolescents.Brain and behavior · 2019Article
- Multimodal neuroimaging analysis reveals age-associated common and discrete cognitive control constructs.Human brain mapping · 2019Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
Although the relationship between structural differences within the prefrontal cortex (PFC) and executive function (EF) has been widely explored in cognitively impaired populations, little is known about this relationship in healthy young adults. Using optimized voxel-based morphometry (VBM), surface-based morphometry (SBM), and fractional anisotropy (FA) we determined the association between regional PFC grey matter (GM) morphometry and white matter tract diffusivity with performance on tasks that tap different aspects of EF as drawn from Miyake et al.'s three-factor model of EF. Reductions in both GM volume (VBM) and cortical folding (SBM) in the ventromedial PFC (vmPFC), ventrolateral PFC (vlPFC), and dorsolateral PFC (dlPFC) predicted better common EF, shifting-specific, and updating-specific performance, respectively. Despite capturing different components of GM morphometry, voxel- and surface-based findings were highly related, exhibiting regionally overlapping relationships with EF. Increased white matter FA in fiber tracts that connect the vmPFC and vlPFC with posterior regions of the brain also predicted better common EF and shifting-specific performance, respectively. These results suggest that the neural mechanisms supporting distinct aspects of EF may differentially rely on distinct regions of the PFC, and at least in healthy young adults, are influenced by regional morphometry of the PFC and the FA of major white matter tracts that connect the PFC with posterior cortical and subcortical regions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.