ReviewEpigenetics2014
Chromatin without the 30-nm fiber: constrained disorder instead of hierarchical folding.
Review in Epigenetics, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 51 citations in OpenAlex.
- Mixing chromatin fibers with different nucleosome repeat lengths changes dynamics of chromatin phase separation.The Journal of biological chemistry · 2026Article
- Denoising Autoencoder Trained on Simulation-Derived Structures for Noise Reduction in Chromatin Scanning Transmission Electron Microscopy.ACS central science · 2023Article
- Molecular organization of the early stages of nucleosome phase separation visualized by cryo-electron tomography.Molecular cell · 2022Article
- Analysis of three-dimensional chromatin packing domains by chromatin scanning transmission electron microscopy (ChromSTEM).Scientific reports · 2022Article
- Loops, topologically associating domains, compartments, and territories are elastic and robust to dramatic nuclear volume swelling.Scientific reports · 2022Article
- Interphase epichromatin: last refuge for the 30-nm chromatin fiber?Chromosoma · 2021Review
- Regulation of Expression and Latency in BLV and HTLV.Viruses · 2020Review
- Weak interactions in higher-order chromatin organization.Nucleic acids research · 2020Review
- The Biochemistry and Evolution of the Dinoflagellate Nucleus.Microorganisms · 2019Review
- The 10-nm chromatin fiber and its relationship to interphase chromosome organization.Biochemical Society transactions · 2018Review
- Chromatin Regulation and the Histone Code in HIV Latency .The Yale journal of biology and medicine · 2017Review
- Identifying Nuclear Matrix-Attached DNA Across the Genome.Journal of cellular physiology · 2017Article
- 3D genomics imposes evolution of the domain model of eukaryotic genome organization.Chromosoma · 2017Review
- Binding of DNA-bending non-histone proteins destabilizes regular 30-nm chromatin structure.PLoS computational biology · 2017Article
- Single-cell genome-wide studies give new insight into nongenetic cell-to-cell variability in animals.Histochemistry and cell biology · 2016Review
- Topologically-associating domains: gene warehouses adapted to serve transcriptional regulation.Transcription · 2016Review
- Unraveling the mechanisms of chromatin fibril packaging.Nucleus (Austin, Tex.) · 2016Article
- Dynamic and flexible H3K9me3 bridging via HP1β dimerization establishes a plastic state of condensed chromatin.Nature communications · 2016Article
- 4D Visualization of replication foci in mammalian cells corresponding to individual replicons.Nature communications · 2016Article
- Novel insights into mitotic chromosome condensation.F1000Research · 2016Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Several hierarchical levels of DNA packaging are believed to exist in chromatin, starting from a 10-nm chromatin fiber that is further packed into a 30-nm fiber. Transitions between the 30-nm and 10-nm fibers are thought to be essential for the control of chromatin transcriptional status. However, recent studies demonstrate that in the nuclei, DNA is packed in tightly associated 10-nm fibers that are not compacted into 30-nm fibers. Additionally, the accessibility of DNA in chromatin depends on the local mobility of nucleosomes rather than on decompaction of chromosome regions. These findings argue for reconsidering the hierarchical model of chromatin packaging and some of the basic definitions of chromatin. In particular, chromatin domains should be considered as three-dimensional objects, which may include genomic regions that do not necessarily constitute a continuous domain on the DNA chain.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.