Evidence map›Paper›PMID 24561546›Full record

ArticleMedical science monitor : international medical journal of experimental and clinical research2014

Carotid surgery affects plasma kynurenic acid concentration: a pilot study.

Piotr Terlecki, Paulina Pawlik, Adam Iwaniuk, Tomasz Kocki, Stanisław Przywara, Marek Ilzecki, Tomasz Zubilewicz, Michał Kowalczyk, Jolanta Parada-Turska, Wojciech Dąbrowski

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In one paragraph

Article in Medical science monitor : international medical journal of experimental and clinical research, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 48% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 4 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Piotr TerleckiDepartment of Vascular Surgery and Angiology, Medical University of Lublin, Lublin, Poland.
Paulina PawlikDepartment of Clinical and Experimental Pharmacology, Medical University of Lublin, Lublin, Poland.
Adam IwaniukDepartment of Anaesthesiiology and Intensive Therapy, Medical University of Lublin, Lublin, Poland.
Tomasz KockiDepartment of Clinical and Experimental Pharmacology, Medical University of Lublin, Lublin, Poland.
Stanisław PrzywaraDepartment of Vascular Surgery and Angiology, Medical University of Lublin, Lublin, Poland.
Marek IlzeckiDepartment of Vascular Surgery and Angiology, Medical University of Lublin, Lublin, Poland.
Tomasz ZubilewiczDepartment of Vascular Surgery and Angiology, Medical University of Lublin, Lublin, Poland.
Michał KowalczykDepartment of Anaesthesiiology and Intensive Therapy, Medical University of Lublin, Lublin, Poland.
Jolanta Parada-TurskaDepartment of Rheumatology and Connective Tissue Diseases, Medical University of Lublin, Lublin, Poland.
Wojciech DąbrowskiDepartment of Anesthesiology and Intensive Therapy, Medical University of Lublin, Lublin, Poland.
Medical University of Lublin · PL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAn increase in plasma kynurenic acid (KYNA) concentration has been observed following surgery, inflammation, and cerebral pathologies. The aim of the present study was to analyze the changes in plasma KYNA concentration in patients undergoing carotid surgery (CS). MATERIAL AND

methodsAdult patients undergoing elective carotid endarterectomy (CEA) or carotid angioplasty with stent placement (CAS) were studied. Plasma KYNA concentrations were analyzed before surgery and at 4 time points after CS. The amount of inflammation was measured as neutrophil-lymphocyte ratio (NLR).

resultsForty patients (10 female and 30 male) aged 55-86 years of age were evaluated in this study. In patients with unstable carotid plaque, the plasma KYNA concentration was higher than in patients with stable carotid plaque. Moreover, the NLR was significantly higher in patients with unstable carotid plaque undergoing CEA than in patients undergoing CAS. Plasma KYNA concentration increased after surgery in patients undergoing CEA and CAS. There was a strong correlation between plasma KYNA concentration and NLR in patients with postoperative neurological disorders.

conclusionsCS increases plasma KYNA concentration, and changes in plasma KYNA concentration can indicate neurologic outcomes in patients undergoing CS.

Indexed as

AgedAged, 80 and overAnalysis of VarianceAngioplastyCarotid ArteriesEndarterectomy, CarotidFemaleHumansKynurenic AcidLymphocytesMaleMiddle AgedNeutrophilsPlaque, AtheroscleroticKynurenic Acid

Identifiers

PMID24561546
PMCPMC3937007
OpenAlexW2088680854

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.