Evidence map›Paper›PMID 24561545›Full record

ArticleMedical science monitor : international medical journal of experimental and clinical research2014

Cysteinyl leukotriene receptor antagonist regulates allergic airway inflammation in an organ- and cytokine-specific manner.

Tetsuya Kawano, Hiroto Matsuse, Tomoko Tsuchida, Susumu Fukahori, Chizu Fukushima, Tomoya Nishino, Shigeru Kohno

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Medical science monitor : international medical journal of experimental and clinical research, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
0.7field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it, 4 citations in OpenAlex.

  1. A meta-analysis of IL-13 polymorphisms and pediatric asthma risk.Medical science monitor : international medical journal of experimental and clinical research · 2014
    Pooled it
  2. Article
  3. Have recent investigations into remission from childhood asthma helped in understanding the pathogenesis of this disease?Medical science monitor : international medical journal of experimental and clinical research · 2015
    Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Tetsuya KawanoSecond Department of Internal Medicine, Nagasaki University Hospital, Nagasaki, Japan.
Hiroto MatsuseSecond Department of Internal Medicine, Nagasaki University Hospital, Nagasaki, Japan.
Tomoko TsuchidaSecond Department of Internal Medicine, Nagasaki University Hospital, Nagasaki, Japan.
Susumu FukahoriSecond Department of Internal Medicine, Nagasaki University School of Medicine, Nagasaki, Japan.
Chizu FukushimaSecond Department of Internal Medicine, Nagasaki University Hospital, Nagasaki, Japan.
Tomoya NishinoSecond Department of Internal Medicine, Nagasaki University Hospital, Nagasaki, Japan.
Shigeru KohnoSecond Department of Internal Medicine, Nagasaki University Hospital, Nagasaki, Japan.
Nagasaki University Hospital · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundCysteinyl leukotrienes (cys-LTs) are very important factors in the pathophysiology of bronchial asthma. Cys-LT receptor antagonists (LTRAs) decrease allergic airway inflammation. The aim of the present study was to determine the differential effects of LTRAs and corticosteroids on allergic airway inflammation and allergen-specific cytokine production from lymphoid tissues using a murine model of asthma. MATERIAL AND

methodsFour groups of female BALB/c mice [control (Cont); Dermatophagoides farinae allergen-sensitized (AS); pranlukast (Prl), an LTRA-treated AS; and dexamethasone (Dex)-treated AS] were examined. Lung pathology and cytokine production by prepared mononuclear cells isolated from mediastinal lymph nodes (MLNs) and spleen were compared among these groups.

resultsAS mice exhibited allergic airway inflammation and significant increases in allergen-specific Th1 and Th2 cytokines in MLNs and spleen. Prl-treated mice showed significant attenuation of allergic airway inflammation concomitant with reduction of Th2 cytokines and IFN-g in MLNs but not in spleen. In contrast, Dex significantly decreased Th1 and Th2 cytokines in MLNs and also decreased them (except IL-13 and IL-2) in spleen.

conclusionsThe inflammatory effects of cys-LTs could differ in lymphoid organs. LTRAs potentially regulate allergic airway inflammation in an organ- and cytokine-specific manner, while systemic corticosteroid shows nonspecific effects.

Indexed as

Adrenal Cortex HormonesAnalysis of VarianceAnimalsAsthmaBronchoalveolar Lavage FluidCell CountChromonesCytokinesFemaleLeukocytes, MononuclearLeukotriene AntagonistsLungLymph NodesMiceMice, Inbred BALB CReceptors, LeukotrieneAdrenal Cortex HormonesChromonesCytokinesLeukotriene Antagonistsleukotriene D4 receptorpranlukastReceptors, Leukotriene

Identifiers

PMID24561545
PMCPMC3937047
OpenAlexW2023823271

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.