ArticleCortex; a journal devoted to the study of the nervous system and behavior2014
Quantitative multi-modal MRI of the Hippocampus and cognitive ability in community-dwelling older subjects.
Article in Cortex; a journal devoted to the study of the nervous system and behavior, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
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Who cites it
14 citing papers in PubMed.
- Cortical mean diffusivity detects early age-related changes and associates with cognition and plasma biomarkers.Brain communications · 2026Article
- Neurite dispersion and density mediates the relationship between cardiorespiratory fitness and cognition in healthy younger adults.Neuropsychologia · 2022Article
- Hippocampal and Parahippocampal Gray Matter Structural Integrity Assessed by Multimodal Imaging Is Associated with Episodic Memory in Old Age.Cerebral cortex (New York, N.Y. : 1991) · 2021Article
- Imaging neurovascular, endothelial and structural integrity in preparation to treat small vessel diseases. The INVESTIGATE-SVDs study protocol. Part of the SVDs@Target project.Cerebral circulation - cognition and behavior · 2021Article
- Microstructural Integrity of the Hippocampus During Childhood: Relations With Age and Source Memory.Frontiers in psychology · 2020Article
- Volumetric and microstructural regional changes of the hippocampus underlying development of recall performance after extended retention intervals.Developmental cognitive neuroscience · 2019Article
- Longitudinal development of hippocampal subregions from childhood to adulthood.Developmental cognitive neuroscience · 2018Article
- Coupled changes in hippocampal structure and cognitive ability in later life.Brain and behavior · 2018Article
- Visit-to-Visit Blood Pressure Variability in Young Adulthood and Hippocampal Volume and Integrity at Middle Age: The CARDIA Study (Coronary Artery Risk Development in Young Adults).Hypertension (Dallas, Tex. : 1979) · 2017Article
- Tau aggregation influences cognition and hippocampal atrophy in the absence of beta-amyloid: a clinico-imaging-pathological study of primary age-related tauopathy (PART).Acta neuropathologica · 2017Article
- Associations between hippocampal morphology, diffusion characteristics, and salivary cortisol in older men.Psychoneuroendocrinology · 2017Article
- Hippocampal morphology and cognitive functions in community-dwelling older people: the Lothian Birth Cohort 1936.Neurobiology of aging · 2017Article
- Blood pressure and sodium: Association with MRI markers in cerebral small vessel disease.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2016Article
- Does white matter structure or hippocampal volume mediate associations between cortisol and cognitive ageing?Psychoneuroendocrinology · 2015Article
Corrections and comments
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Authors and funding
11 authors.
Funding
Abstract
Hippocampal structural integrity is commonly quantified using volumetric measurements derived from brain magnetic resonance imaging (MRI). Previously reported associations with cognitive decline have not been consistent. We investigate hippocampal integrity using quantitative MRI techniques and its association with cognitive abilities in older age. Participants from the Lothian Birth Cohort 1936 underwent brain MRI at mean age 73 years. Longitudinal relaxation time (T1), magnetization transfer ratio (MTR), fractional anisotropy (FA) and mean diffusivity (MD) were measured in the hippocampus. General factors of fluid-type intelligence (g), cognitive processing speed (speed) and memory were obtained at age 73 years, as well as childhood IQ test results at age 11 years. Amongst 565 older adults, multivariate linear regression showed that, after correcting for ICV, gender and age 11 IQ, larger left hippocampal volume was significantly associated with better memory ability (β = .11, p = .003), but not with speed or g. Using quantitative MRI and after correcting for multiple testing, higher T1 and MD were significantly associated with lower scores of g (β range = -.11 to -.14, p < .001), speed (β range = -.15 to -.20, p < .001) and memory (β range = -.10 to -.12, p < .001). Higher MTR and FA in the hippocampus were also significantly associated with higher scores of g (β range = .17 to .18, p < .0001) and speed (β range = .10 to .15, p < .0001), but not memory. Quantitative multi-modal MRI assessments were more sensitive at detecting cognition-hippocampal integrity associations than volumetric measurements, resulting in stronger associations between MRI biomarkers and age-related cognition changes.
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