ArticleDevelopmental cell2014
Rab11 endosomes contribute to mitotic spindle organization and orientation.
Article in Developmental cell, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 90 papers.
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Who cites it
90 citing papers in PubMed, 126 citations in OpenAlex.
- A Quarter Century of EHD Protein Research: From Endosomal Recycling to Ciliopathies.Traffic (Copenhagen, Denmark) · 2026Review
- A Predictive Model for Coupling Cell Division Orientation to Tissue Mechanics During Epithelial Morphogenesis.bioRxiv : the preprint server for biology · 2026Article
- A predictive model for coupling cell division orientation to tissue mechanics during epithelial morphogenesis.Frontiers in cell and developmental biology · 2026Article
- Unconventional Protein Transport Across the Golgi Ribbon.Sub-cellular biochemistry · 2026Review
- The KIF13A-Rab11a axis: a key regulator of vesicle trafficking in cytokinesis.EXCLI journal · 2026Article
- Proteins involved in cell division have broad developmental functions.Developmental biology · 2025Article
- Mitotic spindle membranes.Molecular biology of the cell · 2025Review
- Annexin A2 and lamin B join membrane recycling compartments for the assembly of biomolecular condensates operating in mitotic partitioning.Frontiers in cell and developmental biology · 2025Article
- Tight Junction Component Occludin Binds to FIP5 to Regulate Endosome Trafficking and Mitotic Spindle Function.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- Article
- Dysregulation of the endoplasmic reticulum blocks recruitment of centrosome-associated proteins resulting in mitotic failure.Development (Cambridge, England) · 2023Article
- RAB11A and RAB11B control mitotic spindle function in intestinal epithelial progenitor cells.EMBO reports · 2023Article
- Centrosome Movements Are TUBG1-Dependent.International journal of molecular sciences · 2023Article
- Mechanisms of microtubule organization in differentiated animal cells.Nature reviews. Molecular cell biology · 2022Review
- Rab11 endosomes and Pericentrin coordinate centrosome movement during pre-abscission in vivo.Life science alliance · 2022Article
- Fine-tuning cell organelle dynamics during mitosis by small GTPases.Frontiers of medicine · 2022Review
- Aurora kinase blockade drives de novo addiction of cervical squamous cell carcinoma to druggable EGFR signalling.Oncogene · 2022Article
- C53 Interacting with UFM1-Protein Ligase 1 Regulates Microtubule Nucleation in Response to ER Stress.Cells · 2022Article
- Endolysosomal Mesoporous Silica Nanoparticle Trafficking along Microtubular Highways.Pharmaceutics · 2021Article
- Review
30 more citing papers are in PubMed but not listed here.
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
During interphase, Rab11-GTPase-containing endosomes recycle endocytic cargo. However, little is known about Rab11 endosomes in mitosis. Here, we show that Rab11 localizes to the mitotic spindle and regulates dynein-dependent endosome localization at poles. We found that mitotic recycling endosomes bind γ-TuRC components and associate with tubulin in vitro. Rab11 depletion or dominant-negative Rab11 expression disrupts astral microtubules, delays mitosis, and redistributes spindle pole proteins. Reciprocally, constitutively active Rab11 increases astral microtubules, restores γ-tubulin spindle pole localization, and generates robust spindles. This suggests a role for Rab11 activity in spindle pole maturation during mitosis. Rab11 depletion causes misorientation of the mitotic spindle and the plane of cell division. These findings suggest a molecular mechanism for the organization of astral microtubules and the mitotic spindle through Rab11-dependent control of spindle pole assembly and function. We propose that Rab11 and its associated endosomes cocontribute to these processes through retrograde transport to poles by dynein.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.