Evidence map›Paper›PMID 24560929›Full record

ReviewBiochimica et biophysica acta2014

Understanding the relationship between DNA methylation and histone lysine methylation.

Nathan R Rose, Robert J Klose

Open access · hybridAbstract readReview
In one paragraph

Review in Biochimica et biophysica acta, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 296 papers.

0numbers the graph read from it
0cells of the map it votes in
296citing papers in PubMed
21.2field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

296 citing papers in PubMed, 551 citations in OpenAlex.

  1. Review
  2. Article
  3. Epigenetic regulation of transgenes.Journal of biotechnology · 2026
    Review
  4. Review
  5. Review
  6. Review
  7. Article
  8. Article
  9. Integration of epigenetics into ecotoxicology: insights and fundamental research needs.Biological reviews of the Cambridge Philosophical Society · 2026
    Review
  10. Article
  11. Article
  12. Review
  13. Article
  14. Article
  15. Article
  16. Review
  17. Article
  18. Article
  19. Article
  20. Review

236 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Nathan R RoseDepartment of Biochemistry, South Parks Road, University of Oxford, Oxford OX1 3QU, UK.
Robert J KloseDepartment of Biochemistry, South Parks Road, University of Oxford, Oxford OX1 3QU, UK. Electronic address: rob.klose@bioch.ox.ac.uk.
University of Oxford · GB

Funding

Cancer Research UKWellcome Trust 98024
6 · The paper itself

Abstract

DNA methylation acts as an epigenetic modification in vertebrate DNA. Recently it has become clear that the DNA and histone lysine methylation systems are highly interrelated and rely mechanistically on each other for normal chromatin function in vivo. Here we examine some of the functional links between these systems, with a particular focus on several recent discoveries suggesting how lysine methylation may help to target DNA methylation during development, and vice versa. In addition, the emerging role of non-methylated DNA found in CpG islands in defining histone lysine methylation profiles at gene regulatory elements will be discussed in the context of gene regulation.

Indexed as

Protein Processing, Post-TranslationalAnimalsCpG IslandsDNA MethylationHistone-Lysine N-MethyltransferaseHistone MethyltransferasesHistonesHumansLysineMethylationHistone-Lysine N-MethyltransferaseHistone MethyltransferasesHistonesLysineCpG islandDNA methylationEmbryonic developmentEpigeneticsHistone lysine methylation

Identifiers

PMID24560929
PMCPMC4316174
OpenAlexW1975046046

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.