ArticleNeuron2014
A transcription factor network coordinates attraction, repulsion, and adhesion combinatorially to control motor axon pathway selection.
Article in Neuron, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
17 citing papers in PubMed, 34 citations in OpenAlex.
- Cross-species evidence for a developmental origin of adult hypersomnia with loss of synaptic adhesion molecules beat-Ia/CADM2.Nature communications · 2026Article
- JNK signaling in pioneer neurons organizes ventral nerve cord architecture in Drosophila embryos.Nature communications · 2023Article
- Epilepsy geneiScience · 2023Article
- Transcription factor Acj6 controls dendrite targeting via a combinatorial cell-surface code.Neuron · 2022Article
- A combinatorial code of transcription factors specifies subtypes of visual motion-sensing neurons inDevelopment (Cambridge, England) · 2020Article
- Review
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- The PDZ-GEF Gef26 regulates synapse development and function via FasII and Rap1 at the Drosophila neuromuscular junction.Experimental cell research · 2019Article
- Genetic Modifiers of Neurodegeneration in aGenetics · 2018Article
- Article
- Islet Coordinately Regulates Motor Axon Guidance and Dendrite Targeting through the Frazzled/DCC Receptor.Cell reports · 2017Article
- Hox Proteins Coordinate Motor Neuron Differentiation and Connectivity Programs through Ret/Gfrα Genes.Cell reports · 2016Article
- Article
- Article
- The Unc-5 Receptor Is Directly Regulated by Tinman in the Developing Drosophila Dorsal Vessel.PloS one · 2015Article
- Transcription factors and effectors that regulate neuronal morphology.Development (Cambridge, England) · 2014Review
- Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
Abstract
Combinations of transcription factors (TFs) instruct precise wiring patterns in the developing nervous system; however, how these factors impinge on surface molecules that control guidance decisions is poorly understood. Using mRNA profiling, we identified the complement of membrane molecules regulated by the homeobox TF Even-skipped (Eve), the major determinant of dorsal motor neuron (dMN) identity in Drosophila. Combinatorial loss- and gain-of-function genetic analyses of Eve target genes indicate that the integrated actions of attractive, repulsive, and adhesive molecules direct eve-dependent dMN axon guidance. Furthermore, combined misexpression of Eve target genes is sufficient to partially restore CNS exit and can convert the guidance behavior of interneurons to that of dMNs. Finally, we show that a network of TFs, comprised of eve, zfh1, and grain, induces the expression of the Unc5 and Beaten-path guidance receptors and the Fasciclin 2 and Neuroglian adhesion molecules to guide individual dMN axons.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.