Trial reportBiological psychiatry2014
Alcohol-induced impairment of inhibitory control is linked to attenuated brain responses in right fronto-temporal cortex.
Trial report in Biological psychiatry, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
46 citing papers in PubMed, 101 citations in OpenAlex.
- Heightened sensitivity to the disinhibiting effect of alcohol in women during the late follicular phase of the menstrual cycle.Experimental and clinical psychopharmacology · 2023Trial
- Change in brain asymmetry reflects level of acute alcohol intoxication and impacts on inhibitory control.Scientific reports · 2023Trial
- Neural correlates of inhibitory control are associated with stimulant-like effects of alcohol.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2021Trial
- Acute alcohol does not impair attentional inhibition as measured with Stroop interference scores but impairs Stroop performance.Psychopharmacology · 2021Trial
- The acute effects of alcohol on state rumination in the laboratory.Psychopharmacology · 2021Trial
- Cognitive-emotional mechanisms of alcohol intoxication-involved HIV-risk behavior among men who have sex with men (MSM).Experimental and clinical psychopharmacology · 2021Trial
- Trial
- Alcohol effects on globus pallidus connectivity: Role of impulsivity and binge drinking.PloS one · 2020Trial
- Dose-dependent effects of intravenous alcohol administration on cerebral blood flow in young adults.Psychopharmacology · 2015Trial
- Moderating effect of working memory capacity on acute alcohol effects on BOLD response during inhibition and error monitoring in male heavy drinkers.Psychopharmacology · 2015Trial
- Acute effects of alcohol on brain perfusion monitored with arterial spin labeling magnetic resonance imaging in young adults.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2014Trial
- Using deep learning to identify brain networks mediating cognitive and motor impairments in alcohol use disorder.Translational psychiatry · 2026Article
- Decoding the bidirectional links between alcohol misuse and aggression: toward a unified translational framework.Psychopharmacology · 2026Review
- Brain Activation Features in Response to the Expectation of Receiving Rewards Through Aggression.Brain sciences · 2025Article
- Self-underestimation of BAC as a predictor of risky driving in heavy drinkers.Drug and alcohol dependence · 2025Article
- Article
- Creativity and Mental Illness: A Case Study of a Patient with Progressive Bulbar Palsy.Brain sciences · 2024Review
- Impulsivity in ADHD and Borderline Personality Disorder: A Systematic Review of Gray and White Matter Variations.Journal of clinical medicine · 2024Review
- Blunted neural reward response to alcohol and greater alcohol motivation in binge drinkers in a randomized clinical experiment.Alcohol, clinical & experimental research · 2023Article
- Heightened motor impairment as a protective factor against heavy drinking in individuals with high alcohol-induced disinhibition.Alcohol, clinical & experimental research · 2023Article
Corrections and comments
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Authors and funding
11 authors at 2 institutions in 2 countries.
Funding
Abstract
backgroundA self-enhancing loop between impaired inhibitory control under alcohol and alcohol consumption has been proposed as a possible mechanism underlying dysfunctional drinking in susceptible people. However, the neural underpinnings of alcohol-induced impairment of inhibitory control are widely unknown.
methodsWe measured inhibitory control in 50 young adults with a stop-signal task during functional magnetic resonance imaging. In a single-blind placebo-controlled cross-over design, all participants performed the stop-signal task once under alcohol with a breath alcohol concentration of .6 g/kg and once under placebo. In addition, alcohol consumption was assessed with a free-access alcohol self-administration paradigm in the same participants.
resultsInhibitory control was robustly decreased under alcohol compared with placebo, indicated by longer stop-signal reaction times. On the neural level, impaired inhibitory control under alcohol was associated with attenuated brain responses in the right fronto-temporal portion of the inhibition network that supports the attentional capture of infrequent stop-signals and subsequent updating of action plans from response execution to inhibition. Furthermore, the extent of alcohol-induced impairment of inhibitory control predicted free-access alcohol consumption.
conclusionsWe suggest that during inhibitory control alcohol affects cognitive processes preceding actual motor inhibition. Under alcohol, decreased brain responses in right fronto-temporal areas might slow down the attentional capture of infrequent stop-signals and subsequent updating of action plans, which leads to impaired inhibitory control. In turn, pronounced alcohol-induced impairment of inhibitory control might enhance alcohol consumption in young adults, which might promote future alcohol problems.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.