Evidence map›Paper›PMID 24560520›Full record

SynthesisAmerican journal of human genetics2014

Gene-centric meta-analysis in 87,736 individuals of European ancestry identifies multiple blood-pressure-related loci.

Vinicius Tragante, Michael R Barnes, Santhi K Ganesh, Matthew B Lanktree, Wei Guo, Nora Franceschini, Erin N Smith, Toby Johnson, Michael V Holmes, Sandosh Padmanabhan and 126 more

Open access · bronzeAbstract readMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in American journal of human genetics, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 89 papers, 9 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
89citing papers in PubMed, 9 pooled it
19.4field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

89 citing papers in PubMed, 9 syntheses or guidelines pooled it, 164 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Guideline
  5. Pooled it
  6. Pooled it
  7. Pooled it
  8. Pooled it
  9. Pooled it
  10. Trial
  11. Article
  12. Article
  13. Article
  14. Review
  15. Review
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  18. Review
  19. Ancestral Origins and Admixture History of Kazakhs.Molecular biology and evolution · 2024
    Article
  20. Review

29 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

136 authors at 20 institutions in 8 countries.

Vinicius TraganteDepartment of Cardiology, Division Heart and Lungs, University Medical Center Utrecht, 3584 CX Utrecht, the Netherlands; Department of Medical Genetics, Biomedical Genetics, University Medical Center Utrecht, 3584 CX Utrecht, the Netherlands.
Michael R BarnesWilliam Harvey Research Institute National Institute for Health Biomedical Research Unit, Barts and the London School of Medicine, Queen Mary University of London, London EC1M 6BQ, UK.
Santhi K GaneshDivision of Cardiovascular Medicine, Departments of Internal Medicine and Human Genetics, University of Michigan Health System, Ann Arbor, MI 48109, USA.
Matthew B LanktreeDepartment of Medicine, McMaster University, Hamilton, ON L8S 4L8, Canada.
Wei GuoDepartment of Epidemiology and Biostatistics, Case Western Reserve University, Cleveland, OH 44106, USA.
Nora FranceschiniDepartment of Epidemiology, University of North Carolina, Chapel Hill, NC 27599, USA.
Erin N SmithDepartment of Pediatrics and Rady's Children's Hospital, University of California at San Diego, School of Medicine, La Jolla, CA 92093, USA.
Toby JohnsonClinical Pharmacology and Barts and The London Genome Centre, William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London EC1M 6BQ, UK.
Michael V HolmesDepartment of Surgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Sandosh PadmanabhanBHF Glasgow Cardiovascular Research Centre, University of Glasgow, Glasgow G12 8TA, UK.
Konrad J KarczewskiDepartment of Genetics, Stanford University School of Medicine, Stanford, CA 94305, USA.
Berta AlmogueraCenter for Applied Genomics, Abramson Research Center, The Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.
John BarnardDepartment of Quantitative Health Sciences, Lerner Research Institute, Cleveland Clinic, Cleveland, OH 44195, USA.
Jens BaumertInstitute of Epidemiology II, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg 85764, Germany.
Yen-Pei Christy ChangDepartments of Medicine and Epidemiology & Public Health, University of Maryland School of Medicine, Baltimore, MD 21201, USA.
Clara C ElbersDepartment of Medical Genetics, Biomedical Genetics, University Medical Center Utrecht, 3584 CX Utrecht, the Netherlands; Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, 3584 CX Utrecht, the Netherlands.
Martin FarrallWellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK; Division of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford OX3 9DU, UK.
Mary E FischerDepartment of Ophthalmology and Visual Sciences, University of Wisconsin, Madison, WI 53726, USA.
Tom R GauntMRC Integrative Epidemiology Unit, School of Social and Community Medicine, University of Bristol, Oakfield House, Oakfield Grove, Bristol BS8 2BN, UK.
Johannes M I H GhoDepartment of Cardiology, Division Heart and Lungs, University Medical Center Utrecht, 3584 CX Utrecht, the Netherlands.
Christian GiegerInstitute of Genetic Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg 85764, Germany.
Anuj GoelWellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK; Division of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford OX3 9DU, UK.
Yan GongDepartment of Pharmacotherapy and Translational Research and Center for Pharmacogenomics, University of Florida, Gainesville, FL 32610, USA.
Aaron IsaacsGenetic Epidemiology Unit, Department of Epidemiology, Erasmus Medical Center, 3015 GE Rotterdam, the Netherlands.
Marcus E KleberMedical Clinic V, Medical Faculty Mannheim, Heidelberg University, Mannheim 68167, Germany.
Irene Mateo LeachDepartment of Cardiology, University of Groningen, University Medical Center Groningen, 9700 RB Groningen, the Netherlands.
Caitrin W McDonoughDepartment of Pharmacotherapy and Translational Research and Center for Pharmacogenomics, University of Florida, Gainesville, FL 32610, USA.
Matthijs F L MeijsDepartment of Cardiology, Division Heart and Lungs, University Medical Center Utrecht, 3584 CX Utrecht, the Netherlands.
Olle MelanderHypertension and Cardiovascular Disease, Department of Clinical Sciences, Lund University, Malmö 20502, Sweden; Centre of Emergency Medicine, Skåne University Hospital, Malmö 20502, Sweden.
Christopher P NelsonDepartment of Cardiovascular Sciences, University of Leicester, Leicester LE3 9QP, UK; NIHR Leicester Cardiovascular Biomedical Research Unit, Glenfield Hospital, Groby Road, Leicester LE3 9QP, UK.
Ilja M NolteDepartment of Epidemiology, University of Groningen, University Medical Center Groningen, 9700 RB Groningen, the Netherlands.
Nathan PankratzInstitute of Human Genetics, Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN 55455, USA.
Tom S PriceMRC SGDP Centre, Institute of Psychiatry, London SE5 8AF, UK.
Jonathan ShafferDepartment of Medicine, Columbia University, New York, NY 10032, USA.
Sonia ShahUCL Genetics Institute, Department of Genetics, Evolution and Environment, University College London, Kathleen Lonsdale Building, Gower Place, London WC1E 6BT, UK.
Maciej TomaszewskiDepartment of Cardiovascular Sciences, University of Leicester, Leicester LE3 9QP, UK.
Peter J van der MostDepartment of Epidemiology, University of Groningen, University Medical Center Groningen, 9700 RB Groningen, the Netherlands.
Erik P A Van IperenDurrer Center for Cardiogenetic Research, ICIN-Netherlands Heart Institute, 3511 GC Utrecht, the Netherlands; Department of Clinical Epidemiology, Biostatistics and Bioinformatics, Academic Medical Center, 1105 AZ Amsterdam, the Netherlands.
Judith M VonkDepartment of Epidemiology, University of Groningen, University Medical Center Groningen, 9700 RB Groningen, the Netherlands.
Kate WitkowskaClinical Pharmacology and Barts and The London Genome Centre, William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London EC1M 6BQ, UK.
Caroline O L WongClinical Pharmacology and Barts and The London Genome Centre, William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London EC1M 6BQ, UK.
Li ZhangDepartment of Quantitative Health Sciences, Lerner Research Institute, Cleveland Clinic, Cleveland, OH 44195, USA.
Amber L BeitelsheesDivision of Endocrinology, Diabetes, and Nutrition, University of Maryland School of Medicine, Baltimore, MD 21201, USA.
Gerald S BerensonDepartment of Epidemiology, Tulane University, New Orleans, LA 70118, USA.
Deepak L BhattBrigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA.
Morris BrownClinical Pharmacology Unit, University of Cambridge, Addenbrookes Hospital, Hills Road, Cambridge CB2 2QQ, UK.
Amber BurtDepartment of Medicine (Medical Genetics), University of Washington, Seattle, WA 98195, USA.
Rhonda M Cooper-DeHoffDepartment of Pharmacotherapy and Translational Research and Center for Pharmacogenomics, University of Florida, Gainesville, FL 32610, USA.
John M ConnellUniversity of Dundee, Ninewells Hospital &Medical School, Dundee DD1 9SY, UK.
Karen J CruickshanksDepartment of Ophthalmology and Visual Sciences, University of Wisconsin, Madison, WI 53726, USA; Department of Population Health Sciences, University of Wisconsin, Madison, WI 53726, USA.
Sean P CurtisMerck Research Laboratories, P.O. Box 2000, Rahway, NJ 07065, USA.
George Davey-SmithMRC Integrative Epidemiology Unit, School of Social and Community Medicine, University of Bristol, Oakfield House, Oakfield Grove, Bristol BS8 2BN, UK.
Christian DellesInstitute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow G12 8TA, UK.
Ron T GansevoortDivision of Nephrology, Department of Medicine, University of Groningen, University Medical Center Groningen, 9700 RB Groningen, the Netherlands.
Xiuqing GuoCedars-Sinai Med Ctr-PEDS, Los Angeles, CA 90048, USA.
Shen HaiqingDivision of Endocrinology, Diabetes, and Nutrition, University of Maryland School of Medicine, Baltimore, MD 21201, USA.
Claire E HastieInstitute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow G12 8TA, UK.
Marten H HofkerJulius Center for Health Sciences and Primary Care, University Medical Center Utrecht, 3584 CX Utrecht, the Netherlands; Department Pathology and Medical Biology, Medical Biology Division, Molecular Genetics, University of Groningen, University Medical Center Groningen, 9700 RB Groningen, the Netherlands.
G Kees HovinghDepartment of Vascular Medicine, Academic Medical Center, 1105 AZ Amsterdam, the Netherlands.
Daniel S KimDepartments of Medicine (Medical Genetics) and Genome Sciences, University of Washington, Seattle, WA 98195, USA.
Susan A KirklandDepartment of Community Health and Epidemiology, Dalhousie University, Halifax, NS B3H 1V7, Canada.
Barbara E KleinDepartment of Ophthalmology and Visual Sciences, University of Wisconsin, Madison, WI 53726, USA.
Ronald KleinDepartment of Ophthalmology and Visual Sciences, University of Wisconsin, Madison, WI 53726, USA.
Yun R LiCenter for Applied Genomics, Abramson Research Center, The Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.
Steffi MaiwaldDepartment of Vascular Medicine, Academic Medical Center, 1105 AZ Amsterdam, the Netherlands.
Christopher Newton-ChehBroad Institute of Harvard and MIT, Massachusetts General Hospital, Boston, MA 02142, USA.
Eoin T O'BrienConway Institute of Biomolecular and Biomedical Research, University College Dublin, Belfield, Dublin 4, Ireland.
N Charlotte Onland-MoretDepartment of Medical Genetics, Biomedical Genetics, University Medical Center Utrecht, 3584 CX Utrecht, the Netherlands; Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, 3584 CX Utrecht, the Netherlands.
Walter PalmasDepartment of Medicine, Columbia University, New York, NY 10032, USA.
Afshin ParsaDivision of Endocrinology, Diabetes, and Nutrition, University of Maryland School of Medicine, Baltimore, MD 21201, USA.
Brenda W PenninxDepartment of Psychiatry/EMGO Institute, VU University Medical Centre, 1081 BT Amsterdam, the Netherlands.
Mary PettingerDivision of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA.
Ramachandran S VasanDepartment of Medicine, Boston University School of Medicine, Framingham, MA 02118, USA.
Jane E RanchalisDepartment of Medicine (Medical Genetics), University of Washington, Seattle, WA 98195, USA.
Paul M RidkerDivision of Preventive Medicine, Brigham and Women's Hospital, Boston, MA 02115, USA; Harvard Medical School, Boston, MA 02115, USA.
Lynda M RoseDivision of Preventive Medicine, Brigham and Women's Hospital, Boston, MA 02115, USA.
Peter SeverInternational Centre for Circulatory Health, Imperial College London, W2 1LA UK.
Daichi ShimboDepartment of Medicine, Columbia University, New York, NY 10032, USA.
Laura SteeleDepartment of Surgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Ronald P StolkDepartment of Epidemiology, University of Groningen, University Medical Center Groningen, 9700 RB Groningen, the Netherlands.
Barbara ThorandInstitute of Epidemiology II, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg 85764, Germany.
Mieke D TripDepartment of Cardiology, Academic Medical Center, 1105 AZ Amsterdam, the Netherlands.
Cornelia M van DuijnGenetic Epidemiology Unit, Department of Epidemiology, Erasmus Medical Center, 3015 GE Rotterdam, the Netherlands.
W Monique VerschurenJulius Center for Health Sciences and Primary Care, University Medical Center Utrecht, 3584 CX Utrecht, the Netherlands; National Institute for Public Health and the Environment (RIVM), 3720 BA Bilthoven, the Netherlands.
Cisca WijmengaDepartment of Genetics, University of Groningen, University Medical Center Groningen, 9700 RB Groningen, the Netherlands.
Sharon WyattSchools of Nursing and Medicine, University of Mississippi Medical Center, Jackson, MS 39216, USA.
J Hunter YoungDepartment of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
Aeilko H ZwindermanDepartment of Clinical Epidemiology, Biostatistics and Bioinformatics, Academic Medical Center, 1105 AZ Amsterdam, the Netherlands.
Connie R BezzinaHeart Failure Research Center, Department of Clinical and Experimental Cardiology, Academic Medical Center, 1105 AZ Amsterdam, the Netherlands; Molecular and Experimental Cardiology Group, Academic Medical Centre, 1105 AZ Amsterdam, the Netherlands.
Eric BoerwinkleHuman Genetics Center and Institute of Molecular Medicine and Division of Epidemiology, University of Texas Health Science Center, Houston, TX 77030, USA.
Juan P CasasFaculty of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, London WC1E 7HT, UK; Genetic Epidemiology Group, Department of Epidemiology and Public Health, University College London, London WC1E 6BT, UK.
Mark J CaulfieldClinical Pharmacology and Barts and The London Genome Centre, William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London EC1M 6BQ, UK.
Aravinda ChakravartiCenter for Complex Disease Genomics, McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
Daniel I ChasmanDivision of Preventive Medicine, Brigham and Women's Hospital, Boston, MA 02115, USA; Harvard Medical School, Boston, MA 02115, USA.
Karina W DavidsonDepartments of Medicine & Psychiatry, Columbia University, New York, NY 10032, USA.
Pieter A DoevendansDepartment of Cardiology, Division Heart and Lungs, University Medical Center Utrecht, 3584 CX Utrecht, the Netherlands.
Anna F DominiczakBHF Glasgow Cardiovascular Research Centre, University of Glasgow, Glasgow G12 8TA, UK.
Garret A FitzGeraldThe Institute for Translational Medicine and Therapeutics, School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
John G GumsDepartments of Pharmacotherapy and Translational Research and Community Health and Family Medicine, University of Florida, Gainesville, FL 32610, USA.
Myriam FornageInstitute of Molecular Medicine and School of Public Health Division of Epidemiology Human Genetics and Environmental Sciences, University of Texas Health Science Center at Houston, Houston, TX 77030, USA.
Hakon HakonarsonCenter for Applied Genomics, Abramson Research Center, The Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA; Department of Pediatrics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Indrani HalderSchool of Medicine, University of Pittsburgh, PA 15261, USA.
Hans L HillegeDepartment of Cardiology, University of Groningen, University Medical Center Groningen, 9700 RB Groningen, the Netherlands.
Thomas IlligResearch Unit of Molecular Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg 85764, Germany; Hannover Unified Biobank, Hannover Medical School, Hannover 30625, Germany.
Gail P JarvikInternational Centre for Circulatory Health, Imperial College London, W2 1LA UK.
Julie A JohnsonDepartment of Pharmacotherapy and Translational Research and Center for Pharmacogenomics, University of Florida, Gainesville, FL 32610, USA.
John J P KasteleinDepartment of Vascular Medicine, Academic Medical Center, 1105 AZ Amsterdam, the Netherlands.
Wolfgang KoenigDepartment of Internal Medicine II - Cardiology, University of Ulm Medical Centre, Ulm 89081, Germany.
Meena KumariDepartment of Epidemiology and Public Health, Division of Population Health, University College London, Torrington Place, London WC1E 7HB, UK.
Winfried MärzMedical Clinic V, Medical Faculty Mannheim, Heidelberg University, Mannheim 68167, Germany; Synlab Academy, Synlab Services GmbH, Mannheim 69214, Germany; Clinical Institute of Medical and Chemical Laboratory Diagnostics, Medical University of Graz, Graz 8036, Austria.
Sarah S MurrayDepartment of Pathology, University of California San Diego, La Jolla, CA 92037, USA.
Jeffery R O'ConnellDivision of Endocrinology, Diabetes, and Nutrition, University of Maryland School of Medicine, Baltimore, MD 21201, USA.
Albertine J OldehinkelInterdisciplinary Center Psychopathology and Emotion Regulation, University of Groningen, University Medical Center Groningen, 9700 RB Groningen, the Netherlands.
James S PankowDivision of Epidemiology and Community Health, University of Minnesota, Minneapolis, MN 55454, USA.
Daniel J RaderCardiovascular Institute, the Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA.
Susan RedlineDepartment of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02215, USA.
Muredach P ReillyCardiovascular Institute, the Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA.
Eric E SchadtDepartment of Genetics and Genomic Sciences, Mount Sinai School of Medicine, New York, NY 10029, USA.
Kandice Kottke-MarchantPathology and Laboratory Medicine Institute, Cleveland Clinic, Cleveland, OH 44195, USA.
Harold SniederDepartment of Epidemiology, University of Groningen, University Medical Center Groningen, 9700 RB Groningen, the Netherlands.
Michael SnyderDepartment of Genetics, Stanford University School of Medicine, Stanford, CA 94305, USA.
Alice V StantonMolecular & Cellular Therapeutics, Royal College of Surgeons in Ireland, 123 St Stephens Green, Dublin 2, Ireland.
Martin D TobinDepartment of Health Sciences, University of Leicester, Leicester LE1 7RH, UK.
André G UitterlindenDepartments of Epidemiology and Internal Medicine, Erasmus Medical Center, 3015 GE Rotterdam, the Netherlands.
Pim van der HarstDepartment of Cardiology, University of Groningen, University Medical Center Groningen, 9700 RB Groningen, the Netherlands; Durrer Center for Cardiogenetic Research, ICIN-Netherlands Heart Institute, 3511 GC Utrecht, the Netherlands; Department of Genetics, University of Groningen, University Medical Center Groningen, 9700 RB Groningen, the Netherlands.
Yvonne T van der SchouwJulius Center for Health Sciences and Primary Care, University Medical Center Utrecht, 3584 CX Utrecht, the Netherlands.
Nilesh J SamaniDepartment of Cardiovascular Sciences, University of Leicester, Leicester LE3 9QP, UK; NIHR Leicester Cardiovascular Biomedical Research Unit, Glenfield Hospital, Groby Road, Leicester LE3 9QP, UK.
Hugh WatkinsWellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK; Division of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford OX3 9DU, UK.
Andrew D JohnsonNational Heart, Lung and Blood Institute Framingham Heart Study, Framingham, MA 01702, USA.
Alex P ReinerDivision of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA.
Xiaofeng ZhuDepartment of Epidemiology and Biostatistics, Case Western Reserve University, Cleveland, OH 44106, USA.
Paul I W de BakkerDepartment of Medical Genetics, Biomedical Genetics, University Medical Center Utrecht, 3584 CX Utrecht, the Netherlands; Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, 3584 CX Utrecht, the Netherlands; Division of Genetics, Brigham and Women's Hospital, Harvard Medical School, Boston, MA and Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
Daniel LevyCenter for Population Studies, National Heart, Lung, and Blood Institute, Framingham, MA 01702, USA.
Folkert W AsselbergsDepartment of Cardiology, Division Heart and Lungs, University Medical Center Utrecht, 3584 CX Utrecht, the Netherlands; Durrer Center for Cardiogenetic Research, ICIN-Netherlands Heart Institute, 3511 GC Utrecht, the Netherlands; Institute of Cardiovascular Science, Faculty of Population Health Sciences, University College London, London WC1E 6BT, UK.
Patricia B MunroeClinical Pharmacology and Barts and The London Genome Centre, William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London EC1M 6BQ, UK. Electronic address: p.b.munroe@qmul.ac.uk.
Brendan J KeatingDepartment of Surgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA; Center for Applied Genomics, Abramson Research Center, The Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA; Department of Pediatrics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA. Electronic address: bkeating@mail.med.upenn.edu.
University Medical Center Utrecht · NLUniversity of Groningen · NLAcademic Medical Center · NLBrigham and Women's Hospital · USUniversity of Florida · USUniversity of Maryland, Baltimore · USUniversity of Pennsylvania · USColumbia University · USHelmholtz Zentrum München · DEUniversity Medical Center Groningen · NLUniversity of Glasgow · GBUniversity of Wisconsin–Madison · USQueen Mary University of London · GBUniversity College London · GBUniversity of Leicester · GBUniversity of Washington Medical Center · USWilliam Harvey Research Institute · GBCardiovascular Institute of the South · USCase Western Reserve University · USCentre for Human Genetics · GB

Funding

UCLA Clinical and Translational Science InstituteUL1TR000124 · NCATS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI DUBINETT, STEVEN M. · 2012 to 2015
$57.0M
Transgenic & Knock-out MouseP30DK063491 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Andrea L Hevener · 2003 to 2026
$40.4M
POSTDOCTORAL TRAINING IN MEDICAL INFORMATION SCIENCEST15LM007033 · NLM · STANFORD UNIVERSITY · PI SYLVIA KATINA PLEVRITIS · 1985 to 2026
$25.5M
Cardiovascular Genomics and Bioinformatics projectsZIAHL006170 · NHLBI · NATIONAL HEART, LUNG, AND BLOOD INSTITUTE · PI JOHNSON, ANDREW · 2013 to 2025
$25.3M
FAMILIAL AND BIRTH COHORT EFFECTS ON THE AGING SENSESR01AG021917 · NIA · UNIVERSITY OF WISCONSIN-MADISON · PI CRUICKSHANKS, KAREN J · 2004 to 2018
$25.2M
Pharmacogenomic Evaluation of Antihypertensive ResponsesU01GM074492 · NIGMS · UNIVERSITY OF FLORIDA · PI JOHNSON, JULIE A. · 2005 to 2014
$20.7M
Research BaseP30DK072488 · NIDDK · UNIVERSITY OF MARYLAND BALTIMORE · PI MITCHELL, BRAXTON D, TAYLOR, SIMEON I. · 2005 to 2019
$17.3M
UF Clinical and Translational Science AwardUL1TR000064 · NCATS · UNIVERSITY OF FLORIDA · PI NELSON, DAVID R · 2012 to 2014
$12.2M
EVOLUTION OF CARDIOVASCULAR RISK WITH NORMAL AGINGR01AG016592 · NIA · TULANE UNIVERSITY OF LOUISIANA · PI CHEN, WEI · 2000 to 2015
$11.7M
Epidemiology of Age-related Hearing LossR37AG011099 · NIA · UNIVERSITY OF WISCONSIN-MADISON · PI CRUICKSHANKS, KAREN J · 2009 to 2018
$7.4M
Genetic & Functional Analyses of Hypertension Susceptibility GenesR01HL088120 · NHLBI · UNIVERSITY OF MARYLAND BALTIMORE · PI CHANG, YEN PEI CHRISTY · 2007 to 2017
$3.9M
Hypertension PharmacogeneticsR01HL074730 · NHLBI · UNIVERSITY OF FLORIDA · PI JOHNSON, JULIE A. · 2003 to 2006
$3.4M
British Heart Foundation FS/11/35/28871British Heart Foundation FS/12/33/29561British Heart Foundation FS/12/8/29377British Heart Foundation FS/14/12/30540British Heart Foundation PG/07/085/23349British Heart Foundation PG/09/022/26739British Heart Foundation SP/08/002/24118Medical Research Council G0802432Medical Research Council G0902313Medical Research Council G9521010Medical Research Council MC_UU_12013/1Medical Research Council MC_UU_12013/8Medical Research Council MR/K006584/1Medical Research Council MR/K013351/1NCATS NIH HHS UL1 TR000064NCATS NIH HHS UL1 TR000124NHLBI NIH HHS R01 HL074730NHLBI NIH HHS R01 HL088120NIA NIH HHS R01 AG016592NIA NIH HHS R01 AG021917NIA NIH HHS R37 AG011099NIDDK NIH HHS P30 DK063491NIDDK NIH HHS P30 DK072488NIGMS NIH HHS U01 GM074492NLM NIH HHS T15 LM007033Wellcome Trust 090532
6 · The paper itself

Abstract

Blood pressure (BP) is a heritable risk factor for cardiovascular disease. To investigate genetic associations with systolic BP (SBP), diastolic BP (DBP), mean arterial pressure (MAP), and pulse pressure (PP), we genotyped ~50,000 SNPs in up to 87,736 individuals of European ancestry and combined these in a meta-analysis. We replicated findings in an independent set of 68,368 individuals of European ancestry. Our analyses identified 11 previously undescribed associations in independent loci containing 31 genes including PDE1A, HLA-DQB1, CDK6, PRKAG2, VCL, H19, NUCB2, RELA, HOXC@ complex, FBN1, and NFAT5 at the Bonferroni-corrected array-wide significance threshold (p < 6 × 10(-7)) and confirmed 27 previously reported associations. Bioinformatic analysis of the 11 loci provided support for a putative role in hypertension of several genes, such as CDK6 and NUCB2. Analysis of potential pharmacological targets in databases of small molecules showed that ten of the genes are predicted to be a target for small molecules. In summary, we identified previously unknown loci associated with BP. Our findings extend our understanding of genes involved in BP regulation, which may provide new targets for therapeutic intervention or drug response stratification.

Indexed as

Blood PressureDiastoleGenetics, PopulationSystoleArterial PressureComputational BiologyEuropeGenetic LociGenome-Wide Association StudyGenotypeHumansPhenotypePolymorphism, Single NucleotideQuality ControlQuantitative Trait LociRisk Factors

Identifiers

PMID24560520
PMCPMC3951943
OpenAlexW2135528729

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.