ArticleSchizophrenia research2014
No evidence that runs of homozygosity are associated with schizophrenia in an Irish genome-wide association dataset.
Article in Schizophrenia research, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.
What it found
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
12 citing papers in PubMed, 1 synthesis or guideline pooled it.
- No association between the Ser9Gly polymorphism of the dopamine receptor D3 gene and schizophrenia: a meta-analysis of family-based association studies.BMC medical genetics · 2020Pooled it
- Article
- Runs of homozygosity analysis reveals consensus homozygous regions affecting production traits in Chinese Simmental beef cattle.BMC genomics · 2021Article
- Global Autozygosity Is Associated with Cancer Risk, Mutational Signature and Prognosis.Cancers · 2020Article
- Alternative Applications of Genotyping Array Data Using Multivariant Methods.Trends in genetics : TIG · 2020Review
- Relationships between estimated autozygosity and complex traits in the UK Biobank.PLoS genetics · 2018Article
- No association between dopamine D3 receptor gene Ser9Gly polymorphism (rs6280) and risk of schizophrenia: an updated meta-analysis.Neuropsychiatric disease and treatment · 2017Article
- Heterozygosity Ratio, a Robust Global Genomic Measure of Autozygosity and Its Association with Height and Disease Risk.Genetics · 2016Article
- No Reliable Association between Runs of Homozygosity and Schizophrenia in a Well-Powered Replication Study.PLoS genetics · 2016Article
- Runs of Homozygosity: Association with Coronary Artery Disease and Gene Expression in Monocytes and Macrophages.American journal of human genetics · 2015Article
- Analysis of exome sequence in 604 trios for recessive genotypes in schizophrenia.Translational psychiatry · 2015Article
- Long contiguous stretches of homozygosity spanning shortly the imprinted loci are associated with intellectual disability, autism and/or epilepsy.Molecular cytogenetics · 2015Article
Corrections and comments
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Authors and funding
10 authors.
Funding
Abstract
Runs of homozygosity (ROH), regions of the genome containing many consecutive homozygous SNPs, may represent two copies of a haplotype inherited from a common ancestor. A rare variant on this haplotype could thus be present in a homozygous and potentially recessive state. To detect rare risk variants for schizophrenia, we performed an ROH analysis in a homogeneous Irish genome wide association study (GWAS) dataset consisting of 1606 cases and 1794 controls. There was no genome-wide excess of ROH in cases compared to controls (p=0.7986). No consensus ROH at individual loci showed association with schizophrenia after genome-wide correction.
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Registered trials
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