ReviewProgress in molecular biology and translational science2014
Modeling molecular pathways of neuronal ischemia.
Review in Progress in molecular biology and translational science, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
10 citing papers in PubMed, 20 citations in OpenAlex.
- Sinomenine in cerebral ischemia: mechanisms, delivery strategies, and the emerging multifunctional biomaterials of the bone-brain axis.Frontiers in medicine · 2025Review
- Electro-metabolic coupling in multi-chambered vascularized human cardiac organoids.Nature biomedical engineering · 2023Article
- Quantitative proteomics revealed extensive microenvironmental changes after stem cell transplantation in ischemic stroke.Frontiers of medicine · 2022Article
- Role of lncRNAs in the Development of Ischemic Stroke and Their Therapeutic Potential.Molecular neurobiology · 2021Review
- Adaptive Immunity Regulation and Cerebral Ischemia.Frontiers in immunology · 2020Review
- The Role of Sirt1 in Ischemic Stroke: Pathogenesis and Therapeutic Strategies.Frontiers in neuroscience · 2018Review
- Multiscale modeling in the clinic: diseases of the brain and nervous system.Brain informatics · 2017Review
- SIRT1-dependent AMPK pathway in the protection of estrogen against ischemic brain injury.CNS neuroscience & therapeutics · 2017Article
- Calcium regulation of HCN channels supports persistent activity in a multiscale model of neocortex.Neuroscience · 2016Article
- Neuronal calcium wave propagation varies with changes in endoplasmic reticulum parameters: a computer model.Neural computation · 2015Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
Neuronal ischemia, the consequence of a stroke (cerebrovascular accident), is a condition of reduced delivery of nutrients to brain neurons. The brain consumes more energy per gram of tissue than any other organ, making continuous blood flow critical. Loss of nutrients, most critically glucose and O2, triggers a large number of interacting molecular pathways in neurons and astrocytes. The dynamics of these pathways take place over multiple temporal scales and occur in multiple interacting cytosolic and organelle compartments: in mitochondria, endoplasmic reticulum, and nucleus. The complexity of these relationships suggests the use of computer simulation to understand the interplay between pathways leading to reversible or irreversible damage, the forms of damage, and interventions that could reduce damage at different stages of stroke. We describe a number of models and simulation methods that can be used to further our understanding of ischemia.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.