Evidence map›Paper›PMID 24560029›Full record

ArticleAlzheimer's & dementia : the journal of the Alzheimer's Association2014

The MultiTEP platform-based Alzheimer's disease epitope vaccine activates a broad repertoire of T helper cells in nonhuman primates.

Hayk Davtyan, Anahit Ghochikyan, Irina Petrushina, Armine Hovakimyan, Arpine Davtyan, David H Cribbs, Michael G Agadjanyan

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Alzheimer's & dementia : the journal of the Alzheimer's Association, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed
1.9field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 34 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Hayk DavtyanDepartment of Molecular Immunology, Institute for Molecular Medicine, Huntington Beach, CA, USA; Institute for Memory Impairments and Neurological Disorders, University of California, Irvine, Irvine, CA, USA.
Anahit GhochikyanDepartment of Molecular Immunology, Institute for Molecular Medicine, Huntington Beach, CA, USA.
Irina PetrushinaInstitute for Memory Impairments and Neurological Disorders, University of California, Irvine, Irvine, CA, USA.
Armine HovakimyanDepartment of Molecular Immunology, Institute for Molecular Medicine, Huntington Beach, CA, USA.
Arpine DavtyanDepartment of Molecular Immunology, Institute for Molecular Medicine, Huntington Beach, CA, USA.
David H CribbsInstitute for Memory Impairments and Neurological Disorders, University of California, Irvine, Irvine, CA, USA; Department of Neurology, University of California, Irvine, Irvine, CA, USA.
Michael G AgadjanyanDepartment of Molecular Immunology, Institute for Molecular Medicine, Huntington Beach, CA, USA; Institute for Memory Impairments and Neurological Disorders, University of California, Irvine, Irvine, CA, USA. Electronic address: magadjanyan@immed.org.
Institute for Molecular Medicine · USUniversity of California, Irvine · US

Funding

Training in the Neurobiology of Aging and Alzheimers DiseaseT32AG000096 · NIA · UNIVERSITY OF CALIFORNIA-IRVINE · PI VIVEK SWARUP, Craig E Stark · 1985 to 2026
$9.6M
Combining AD Epitope Vaccine with Innate ImmunityR01NS050895 · NINDS · UNIVERSITY OF CALIFORNIA-IRVINE · PI AGADJANYAN, MICHAEL G, CRIBBS, DAVID HASTINGS · 2004 to 2018
$7.4M
Multiple Approaches to Abeta Vaccination in Animal ModelsR01AG020241 · NIA · UNIVERSITY OF CALIFORNIA-IRVINE · PI AGADJANYAN, MICHAEL G, CRIBBS, DAVID HASTINGS · 2001 to 2016
$5.6M
A Therapeutic DNA Epitope Vaccine for Alzheimer's DiseaseU44NS065518 · NINDS · ICHOR MEDICAL SYSTEMS, INC. · PI EVANS, CLAIRE FRANCES · 2009 to 2013
$1.8M
NIA NIH HHS R01 AG020241NIA NIH HHS R01-AG20241NIA NIH HHS T32 AG000096NINDS NIH HHS R01 NS050895NINDS NIH HHS R01-NS50895NINDS NIH HHS U44 NS065518NINDS NIH HHS U44NS065518
6 · The paper itself

Abstract

backgroundAs a prelude to clinical trials we have characterized B- and T-cell immune responses in macaques to AD vaccine candidates: AV-1955 and its slightly modified version, AV-1959 (with 3 additional promiscuous Th epitopes).

methodsT- and B-cell epitope mapping was performed using the ELISPOT assay and competition ELISA, respectively.

resultsAV-1955 and AV-1959 did not stimulate potentially harmful autoreactive T cells, but instead activated a broad but individualized repertoire of Th cells specific to the MultiTEP platform in macaques. Although both vaccines induced robust anti-Aβ antibody responses without producing antibodies specific to Th epitopes of MultiTEP platforms, analyses of cellular immune responses in macaques demonstrated that the addition of Th epitopes in the case of AV-1959 created a more potent, superior vaccine.

conclusionAV-1959 is a promising vaccine candidate capable of producing therapeutically potent anti-amyloid antibody in a broader population of vaccinated subjects with high MHC class II gene polymorphisms.

Indexed as

Lymphocyte ActivationAlzheimer DiseaseAlzheimer VaccinesAmyloid beta-PeptidesAnimalsAntibodiesAntibody FormationB-LymphocytesEnzyme-Linked Immunosorbent AssayEnzyme-Linked Immunospot AssayEpitope MappingEpitopes, B-LymphocyteEpitopes, T-LymphocyteFemaleMacaca mulattaMaleAlzheimer VaccinesAmyloid beta-PeptidesAntibodiesEpitopes, B-LymphocyteEpitopes, T-LymphocyteVaccines, DNAAD epitope vaccineAlzheimer's disease (AD)ElectroporationMapping of B- and T-cell immune responsesRhesus macaques

Identifiers

PMID24560029
PMCPMC4008660
OpenAlexW2025698479

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.