ArticleEuropean neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology2014
Adolescent intermittent ethanol exposure diminishes anhedonia during ethanol withdrawal in adulthood.
Article in European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 19 citations in OpenAlex.
- Biotin Mitigates Alcohol Withdrawal-Induced Anxiety and Depression by Regulating Serotonin Metabolism, BDNF, Inflammation, and Oxidative Stress in Rats.Neuropsychopharmacology reports · 2025Article
- Fenofibrate treatment during withdrawal reverses symptoms of ethanol-induced depression in male rats.Frontiers in pharmacology · 2025Article
- Absence of compulsive drinking phenotype in adult male rats exposed to ethanol in a binge-like pattern during adolescence.Alcohol (Fayetteville, N.Y.) · 2019Article
- Stress, sensitive periods, and substance abuse.Neurobiology of stress · 2019Review
- Effects of adolescent alcohol exposure on stress-induced reward deficits, brain CRF, monoamines and glutamate in adult rats.Psychopharmacology · 2018Article
- Repeated Cycles of Binge-Like Ethanol Intake in Adolescent Female Rats Induce Motor Function Impairment and Oxidative Damage in Motor Cortex and Liver, but Not in Blood.Oxidative medicine and cellular longevity · 2018Article
- Effects of early life stress and adolescent ethanol exposure on adult cognitive performance in the 5-choice serial reaction time task in Wistar male rats.Psychopharmacology · 2017Article
- Risky choice and brain CRF after adolescent ethanol vapor exposure and social stress in adulthood.Behavioural brain research · 2016Article
- Distinct Effects of Nalmefene on Dopamine Uptake Rates and Kappa Opioid Receptor Activity in the Nucleus Accumbens Following Chronic Intermittent Ethanol Exposure.International journal of molecular sciences · 2016Article
- Adolescent alcohol exposure decreased sensitivity to nicotine in adult Wistar rats.Addiction biology · 2016Article
- Effects of Acute and Repeated Administration of Oxycodone and Naloxone-Precipitated Withdrawal on Intracranial Self-Stimulation in Rats.The Journal of pharmacology and experimental therapeutics · 2016Article
- Sex differences in the long-lasting consequences of adolescent ethanol exposure for the rewarding effects of cocaine in mice.Psychopharmacology · 2015Article
- Adolescent intermittent ethanol exposure is associated with increased risky choice and decreased dopaminergic and cholinergic neuron markers in adult rats.The international journal of neuropsychopharmacology · 2014Article
- Adolescent alcohol exposure and persistence of adolescent-typical phenotypes into adulthood: a mini-review.Neuroscience and biobehavioral reviews · 2014Review
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Adolescent alcohol use may interfere with neurodevelopment, increasing the likelihood of adult alcohol use disorders (AUDs). We investigated whether adolescent intermittent ethanol (AIE) exposure alters the adult reward response to ethanol. Adolescent rats were administered ethanol once (moderate exposure; Cohort 1) or three times per day (severe exposure; Cohort 2) in a 2 days on/2 days off pattern. In adulthood, subjects responded for electrical stimulation directed at the posterior lateral hypothalamus in a discrete-trial intracranial self-stimulation (ICSS) procedure that provides current-intensity thresholds as a measure of brain reward function. The effects of ethanol administration and withdrawal were assessed. Control rats showed dose-dependent threshold elevations after acute ethanol, indicating reward deficits. A majority of moderately AIE-exposed rats (Cohort 1) showed threshold lowering after ethanol, suggesting ethanol-induced reward enhancement in this sub-set of rats. Rats exposed to severe AIE (Cohort 2) showed no threshold elevation or lowering, suggesting a blunted affective ethanol response. Daily ethanol induced threshold elevations 24h after administration in control rats but not in either group of AIE-exposed rats, suggesting decreased sensitivity to the negative affective state of ethanol withdrawal. Withdrawal from a 4-day ethanol binge produced robust and enduring threshold elevations in all rats, although threshold elevations were diminished in rats exposed to severe AIE. These results indicate that AIE exposure diminished reward deficits associated with ethanol intoxication and withdrawal and may have increased ethanol-induced reward enhancement in a sub-set of rats. In humans, enhanced ethanol reward accompanied by reduced withdrawal severity may contribute to the development of AUDs.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.