ArticleBiophysical journal2014
Mechanical boundary conditions bias fibroblast invasion in a collagen-fibrin wound model.
Article in Biophysical journal, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- Cyclic stretch inhibits cell invasion in 3D scaffolds.bioRxiv : the preprint server for biology · 2026Article
- Towards a more objective and high-throughput spheroid invasion assay quantification method.Scientific reports · 2024Article
- Towards a More Objective and High-throughput Spheroid Invasion Assay Quantification Method.bioRxiv : the preprint server for biology · 2024Article
- Multiscale mechanobiology: Coupling models of adhesion kinetics and nonlinear tissue mechanics.Biophysical journal · 2022Article
- Infarct Collagen Topography Regulates Fibroblast Fate via p38-Yes-Associated Protein Transcriptional Enhanced Associate Domain Signals.Circulation research · 2020Article
- Role of boundary conditions in determining cell alignment in response to stretch.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
- Mechanoregulation of Myofibroblast Fate and Cardiac Fibrosis.Advanced biosystems · 2018Article
- Functional and Biomimetic Materials for Engineering of the Three-Dimensional Cell Microenvironment.Chemical reviews · 2017Review
- Effects of dynamic matrix remodelling onJournal of the Royal Society, Interface · 2017Article
- Remodeling by fibroblasts alters the rate-dependent mechanical properties of collagen.Acta biomaterialia · 2016Article
- Computational modeling of cardiac fibroblasts and fibrosis.Journal of molecular and cellular cardiology · 2016Review
- Patterning of Fibroblast and Matrix Anisotropy within 3D Confinement is Driven by the Cytoskeleton.Advanced healthcare materials · 2016Article
- Article
- Characterization of Fibrin and Collagen Gels for Engineering Wound Healing Models.Materials (Basel, Switzerland) · 2015Article
- Mechanically guided cell migration: less of a stretch than ever.Biophysical journal · 2014Article
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2 authors.
Funding
Abstract
Because fibroblasts deposit the collagen matrix that determines the mechanical integrity of scar tissue, altering fibroblast invasion could alter wound healing outcomes. Anisotropic mechanical boundary conditions (restraint, stretch, or tension) could affect the rate of fibroblast invasion, but their importance relative to the prototypical drivers of fibroblast infiltration during wound healing--cell and chemokine concentration gradients--is unknown. We tested whether anisotropic mechanical boundary conditions affected the directionality and speed of fibroblasts migrating into a three-dimensional model wound, which could simultaneously expose fibroblasts to mechanical, structural, steric, and chemical guidance cues. We created fibrin-filled slits in fibroblast-populated collagen gels and applied uniaxial mechanical restraint along the short or long axis of the fibrin wounds. Anisotropic mechanical conditions increased the efficiency of fibroblast invasion by guiding fibroblasts without increasing their migration speed. The migration behavior could be modeled as a biased random walk, where the bias due to multiple guidance cues was accounted for in the shape of a displacement orientation probability distribution. Taken together, modeling and experiments suggested an effect of strain anisotropy, rather than strain-induced fiber alignment, on fibroblast invasion.
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