ArticleNeuron2014
Neuronal machinery of sleep homeostasis in Drosophila.
Article in Neuron, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 156 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
156 citing papers in PubMed, 294 citations in OpenAlex.
- A half-center oscillator regulates sleep pressure.Nature neuroscience · 2026Article
- Exploring emotional expression in invertebrates: mechanisms, functions and phylogeny.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2026Review
- Article
- Context-dependent arousal via wake-promoting pontine neurons in the Drosophila melanogaster fan-shaped body.Sleep · 2026Article
- Hormonal control of postmitotic neuronal identity.bioRxiv : the preprint server for biology · 2026Article
- Cross-species evidence for a developmental origin of adult hypersomnia with loss of synaptic adhesion molecules beat-Ia/CADM2.Nature communications · 2026Article
- The use ofFrontiers in cell and developmental biology · 2026Review
- Simvastatin modulates sleep-wake behavior and locomotor activity in a dose-dependent manner inFrontiers in pharmacology · 2026Article
- Sleep rescues age-associated loss of glial engulfment.PLoS genetics · 2026Article
- Looking back: tracing the origins of sleep across the animal kingdom.Frontiers in neuroscience · 2026Review
- Sleep regulation inFrontiers in neuroscience · 2026Review
- Convergence-divergence circuits for multimodal integration of innate and learned opponent valences.Frontiers in systems neuroscience · 2026Article
- RHO GTPase by L1 GABAergic neurons in frontal cortex and L6 glutamatergic neurons in prefrontal cortex differentiates states of unconsciousness.Scientific reports · 2025Article
- A switch in arousal circuit architecture shapes sleep across the lifespan.bioRxiv : the preprint server for biology · 2025Article
- Neurobiology of mitochondrial dynamics in sleep.The Journal of physiology · 2025Review
- The Glutamate-gated Chloride Channel Facilitates Sleep by Enhancing the Excitability of Two Pairs of Neurons in the Ventral Nerve Cord of Drosophila.Neuroscience bulletin · 2025Article
- Article
- Mitochondrial origins of the pressure to sleep.Nature · 2025Article
- Sleep drive, not total sleep amount, increases seizure risk.Nature communications · 2025Article
- Clock-dependent regulation of a homeostatic sleep center maintains daytime sleep and evening activity.Current biology : CB · 2025Article
96 more citing papers are in PubMed but not listed here.
Corrections and comments
- Commented on by
- Erratum issued
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Sleep is under homeostatic control, but the mechanisms that sense sleep need and correct sleep deficits remain unknown. Here, we report that sleep-promoting neurons with projections to the dorsal fan-shaped body (FB) form the output arm of Drosophila's sleep homeostat. Homeostatic sleep control requires the Rho-GTPase-activating protein encoded by the crossveinless-c (cv-c) gene in order to transduce sleep pressure into increased electrical excitability of dorsal FB neurons. cv-c mutants exhibit decreased sleep time, diminished sleep rebound, and memory deficits comparable to those after sleep loss. Targeted ablation and rescue of Cv-c in sleep-control neurons of the dorsal FB impair and restore, respectively, normal sleep patterns. Sleep deprivation increases the excitability of dorsal FB neurons, but this homeostatic adjustment is disrupted in short-sleeping cv-c mutants. Sleep pressure thus shifts the input-output function of sleep-promoting neurons toward heightened activity by modulating ion channel function in a mechanism dependent on Cv-c.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.