Evidence map›Paper›PMID 24559652›Full record

ReviewCell calcium2014

Ca²⁺-dependent K⁺ channels in exocrine salivary glands.

Marcelo A Catalán, Gaspar Peña-Munzenmayer, James E Melvin

Open access · greenAbstract readReview
In one paragraph

Review in Cell calcium, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.1field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 29 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. A Mathematical Model of Salivary Gland Duct Cells.Bulletin of mathematical biology · 2022
    Article
  5. Review
  6. Review
  7. Review
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Marcelo A CatalánSecretory Mechanisms and Dysfunction Section (SMDS), National Institute of Dental and Craniofacial Research, National Institutes of Health, 10 Center Drive, Building 10/Room 5N102, Bethesda, MD 20892, USA. Electronic address: marcelo.catalan@nih.gov.
Gaspar Peña-MunzenmayerSecretory Mechanisms and Dysfunction Section (SMDS), National Institute of Dental and Craniofacial Research, National Institutes of Health, 10 Center Drive, Building 10/Room 5N102, Bethesda, MD 20892, USA.
James E MelvinSecretory Mechanisms and Dysfunction Section (SMDS), National Institute of Dental and Craniofacial Research, National Institutes of Health, 10 Center Drive, Building 10/Room 5N102, Bethesda, MD 20892, USA. Electronic address: james.melvin@nih.gov.
National Institutes of Health · US

Funding

NIDCR DIR Secretory Mechanisms and Dysfunctions SectionZIADE000738 · NIDCR · NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH · PI MELVIN, JAMES · 2011 to 2019
$14.4M
NIDCR DIR Clinical TrainingZIEDE000727 · NIDCR · NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH · PI MAYS, JACQUELINE · 2009 to 2025
$6.8M
Intramural NIH HHS ZIA DE000738
6 · The paper itself

Abstract

In the last 15 years, remarkable progress has been realized in identifying the genes that encode the ion-transporting proteins involved in exocrine gland function, including salivary glands. Among these proteins, Ca(2+)-dependent K(+) channels take part in key functions including membrane potential regulation, fluid movement and K(+) secretion in exocrine glands. Two K(+) channels have been identified in exocrine salivary glands: (1) a Ca(2+)-activated K(+) channel of intermediate single channel conductance encoded by the KCNN4 gene, and (2) a voltage- and Ca(2+)-dependent K(+) channel of large single channel conductance encoded by the KCNMA1 gene. This review focuses on the physiological roles of Ca(2+)-dependent K(+) channels in exocrine salivary glands. We also discuss interesting recent findings on the regulation of Ca(2+)-dependent K(+) channels by protein-protein interactions that may significantly impact exocrine gland physiology.

Indexed as

Acinar CellsCalciumHumansIntermediate-Conductance Calcium-Activated Potassium ChannelsPotassiumProtein Interaction Domains and MotifsSalivary GlandsCalciumIntermediate-Conductance Calcium-Activated Potassium ChannelsPotassiumCa(2+)-dependent K(+) channelsEpithelial ion transportExocrine glandsK(+) secretion

Identifiers

PMID24559652
PMCPMC4058408
OpenAlexW2076302704

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.