Evidence map›Paper›PMID 24559646›Full record

ArticleNeurobiology of aging2014

miR-126 contributes to Parkinson's disease by dysregulating the insulin-like growth factor/phosphoinositide 3-kinase signaling.

Woori Kim, Yenarae Lee, Noah D McKenna, Ming Yi, Filip Simunovic, Yulei Wang, Benjamin Kong, Robert J Rooney, Hyemyung Seo, Robert M Stephens and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neurobiology of aging, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 70 papers.

0numbers the graph read from it
0cells of the map it votes in
70citing papers in PubMed
4.4field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

70 citing papers in PubMed, 142 citations in OpenAlex.

  1. Review
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  9. Review
  10. An Overview of Epigenetic Changes in the Parkinson's Disease Brain.International journal of molecular sciences · 2024
    Review
  11. Review
  12. Article
  13. MicroRNA-126 (MiR-126): key roles in related diseases.Journal of physiology and biochemistry · 2024
    Review
  14. Article
  15. Article
  16. Review
  17. Review
  18. Therapeutic Implications of microRNAs in Depressive Disorders: A Review.International journal of molecular sciences · 2022
    Review
  19. Review
  20. Review

10 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 2 countries.

Woori KimDepartment of Psychiatry, McLean Hospital, Harvard Medical School, Belmont, MA, USA; Department of Psychiatry, McLean Hospital, Harvard Medical School, Belmont, MA, USA.
Yenarae LeeDepartment of Psychiatry, McLean Hospital, Harvard Medical School, Belmont, MA, USA.
Noah D McKennaDepartment of Psychiatry, McLean Hospital, Harvard Medical School, Belmont, MA, USA.
Ming YiBioinformatics Support Group, Advanced Biomedical Computing Center, NCI-Frederick, Frederick, MD, USA.
Filip SimunovicDepartment of Psychiatry, McLean Hospital, Harvard Medical School, Belmont, MA, USA.
Yulei WangLife Technologies, Foster City, CA, USA.
Benjamin KongLife Technologies, Foster City, CA, USA.
Robert J RooneyGenome Explorations Inc, Memphis, TN, USA.
Hyemyung SeoDivision of Molecular & Life Sciences, College of Science & Technology, Hanyang University, Seoul, Korea.
Robert M StephensBioinformatics Support Group, Advanced Biomedical Computing Center, NCI-Frederick, Frederick, MD, USA.
Kai C SonntagDepartment of Psychiatry, McLean Hospital, Harvard Medical School, Belmont, MA, USA. Electronic address: ksonntag@mclean.harvard.edu.
Harvard University · USScience Applications International Corporation (United States) · USHanyang University · KR

Funding

miRNAs as regulators of gene expression in Parkinson DiseaseR21NS067335 · NINDS · MCLEAN HOSPITAL · PI SONNTAG, KAI CHRISTIAN · 2009 to 2010
$435k
NINDS NIH HHS R21 NS067335NINDS NIH HHS R21NS067335
6 · The paper itself

Abstract

Dopamine (DA) neurons in sporadic Parkinson's disease (PD) display dysregulated gene expression networks and signaling pathways that are implicated in PD pathogenesis. Micro (mi)RNAs are regulators of gene expression, which could be involved in neurodegenerative diseases. We determined the miRNA profiles in laser microdissected DA neurons from postmortem sporadic PD patients' brains and age-matched controls. DA neurons had a distinctive miRNA signature and a set of miRNAs was dysregulated in PD. Bioinformatics analysis provided evidence for correlations of miRNAs with signaling pathways relevant to PD, including an association of miR-126 with insulin/IGF-1/PI3K signaling. In DA neuronal cell systems, enhanced expression of miR-126 impaired IGF-1 signaling and increased vulnerability to the neurotoxin 6-OHDA by downregulating factors in IGF-1/PI3K signaling, including its targets p85β, IRS-1, and SPRED1. Blocking of miR-126 function increased IGF-1 trophism and neuroprotection to 6-OHDA. Our data imply that elevated levels of miR-126 may play a functional role in DA neurons and in PD pathogenesis by downregulating IGF-1/PI3K/AKT signaling and that its inhibition could be a mechanism of neuroprotection.

Indexed as

BrainCells, CulturedDopaminergic NeuronsDown-RegulationGene Expression RegulationHumansInsulin-Like Growth Factor IMicroRNAsOxidopamineParkinson DiseasePhosphatidylinositol 3-KinasesSignal TransductionInsulin-Like Growth Factor IMicroRNAsMIRN126 microRNA, humanOxidopaminePhosphatidylinositol 3-Kinases6-OHDA neurotoxicityCell systemsDopamine neuronsIGF-1 signalingInsulinLaser capture microdissectionmiR-126miRNAsParkinson's diseasePI3KPostmortem

Identifiers

PMID24559646
PMCPMC3991567
OpenAlexW2096446865

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.