Evidence map›Paper›PMID 24559590›Full record

ReviewTrends in plant science2014

Engineering crassulacean acid metabolism to improve water-use efficiency.

Anne M Borland, James Hartwell, David J Weston, Karen A Schlauch, Timothy J Tschaplinski, Gerald A Tuskan, Xiaohan Yang, John C Cushman

Abstract readReview
In one paragraph

Review in Trends in plant science, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 92 papers.

0numbers the graph read from it
0cells of the map it votes in
92citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

92 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Rhythmic Mechanisms Governing CAM Photosynthesis inInternational journal of molecular sciences · 2026
    Article
  7. Article
  8. Article
  9. Article
  10. Synthetic crassulacean acid metabolism (SynCAM) for improving water-use efficiency in plants.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2025
    Review
  11. Article
  12. A Synthetic Facultative CAM-Like Shuttle in CAdvanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
    Article
  13. Article
  14. Transcriptomic Analysis of the CAM SpeciesPlants (Basel, Switzerland) · 2024
    Article
  15. Review
  16. Article
  17. Article
  18. Engineering Crassulacean Acid Metabolism in CCold Spring Harbor perspectives in biology · 2024
    Review
  19. Review
  20. Article

32 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Anne M BorlandSchool of Biology, Newcastle University, Newcastle upon Tyne NE1 7RU, UK; Biosciences Division, Oak Ridge National Laboratory, Oak Ridge, TN 37831-6407, USA.
James HartwellDepartment of Plant Sciences, Institute of Integrative Biology, University of Liverpool, Liverpool L69 7ZB, UK.
David J WestonBiosciences Division, Oak Ridge National Laboratory, Oak Ridge, TN 37831-6407, USA.
Karen A SchlauchDepartment of Biochemistry and Molecular Biology, MS330, University of Nevada, Reno, NV 89557-0330, USA.
Timothy J TschaplinskiBiosciences Division, Oak Ridge National Laboratory, Oak Ridge, TN 37831-6407, USA.
Gerald A TuskanBiosciences Division, Oak Ridge National Laboratory, Oak Ridge, TN 37831-6407, USA.
Xiaohan YangBiosciences Division, Oak Ridge National Laboratory, Oak Ridge, TN 37831-6407, USA.
John C CushmanDepartment of Biochemistry and Molecular Biology, MS330, University of Nevada, Reno, NV 89557-0330, USA. Electronic address: jcushman@unr.edu.

Funding

Outreach/Diversity/Pipeline ProjectP20GM103440 · NIGMS · UNIVERSITY OF NEVADA RENO · PI Julia Petereit · 2012 to 2026
$58.0M
UNDERGRADUATE RESEARCH AND TRAININGP20RR016464 · NCRR · UNIVERSITY OF NEVADA RENO · PI SCHLAUCH, KAREN · 2001 to 2011
$30.3M
Biotechnology and Biological Sciences Research Council BB/F009313/1NCRR NIH HHS 5P20RR016464-11NCRR NIH HHS P20 RR016464NIGMS NIH HHS 8 P20 GM103440-11NIGMS NIH HHS P20 GM103440
6 · The paper itself

Abstract

Climatic extremes threaten agricultural sustainability worldwide. One approach to increase plant water-use efficiency (WUE) is to introduce crassulacean acid metabolism (CAM) into C3 crops. Such a task requires comprehensive systems-level understanding of the enzymatic and regulatory pathways underpinning this temporal CO2 pump. Here we review the progress that has been made in achieving this goal. Given that CAM arose through multiple independent evolutionary origins, comparative transcriptomics and genomics of taxonomically diverse CAM species are being used to define the genetic 'parts list' required to operate the core CAM functional modules of nocturnal carboxylation, diurnal decarboxylation, and inverse stomatal regulation. Engineered CAM offers the potential to sustain plant productivity for food, feed, fiber, and biofuel production in hotter and drier climates.

Indexed as

Systems BiologyCarbon DioxideCircadian RhythmCrops, AgriculturalGene Regulatory NetworksGenetic EngineeringPhotosynthesisPhylogenyPlant Physiological PhenomenaPlantsPlant StomataWaterCarbon DioxideWaterbiodesignbioenergycrassulacean acid metabolismengineering CAM into C(3) plantswater-use efficiency

Identifiers

PMID24559590
PMCPMC4065858

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.