Evidence map›Paper›PMID 24559451›Full record

ReviewFuture oncology (London, England)2014

A paradigm shift from anatomic to functional and molecular imaging in the detection of recurrent prostate cancer.

Nicholas G Zaorsky, Kosj Yamoah, Madhukar L Thakur, Edouard J Trabulsi, Timothy N Showalter, Mark D Hurwitz, Adam P Dicker, Robert B Den

Open access · greenAbstract readReview
In one paragraph

Review in Future oncology (London, England), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 1 pooled it
2.2field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 1 synthesis or guideline pooled it, 16 citations in OpenAlex.

  1. Pooled it
  2. Tracing prostate cancer - the evolution of PET-CT applications.Reports of practical oncology and radiotherapy : journal of Greatpoland Cancer Center in Poznan and Polish Society of Radiation Oncology · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Nicholas G ZaorskyDepartment of Radiation Oncology, Fox Chase Cancer Center, PA, USA.
Kosj Yamoah
Madhukar L Thakur
Edouard J Trabulsi
Timothy N Showalter
Mark D Hurwitz
Adam P Dicker
Robert B Den
Thomas Jefferson University · USUniversity of Virginia · US

Funding

X-Ray Crystallography and Macromolecular CharacterizationP30CA056036 · NCI · THOMAS JEFFERSON UNIVERSITY · PI Andrew Chapman · 1995 to 2026
$94.8M
VPAC1 Recpetor-Targeted PET Imaging of Prostate CancerR01CA157372 · NCI · THOMAS JEFFERSON UNIVERSITY · PI THAKUR, MATHEW LAXMAN · 2012 to 2017
$2.6M
NCI NIH HHS CA 5R01 157372NCI NIH HHS P30 CA056036NCI NIH HHS P30 CA56036NCI NIH HHS R01 CA157372
6 · The paper itself

Abstract

Approximately a third of men with localized prostate cancer who are treated with external beam radiation therapy (EBRT) or radical prostatectomy (RP) develop biochemical failure (BF). Presumably, BF will progress to distant metastasis and prostate cancer-specific mortality in some patients over subsequent years. Accurate detection of recurrent disease is important because it allows for appropriate treatment selection (e.g., local vs systemic therapy) and early delivery of therapy (e.g., salvage EBRT), which affect patient outcome. In this article, we discuss the paradigm shift in imaging technology in the detection of recurrent prostate cancer. First, we discuss the commonly used morphological and anatomical imaging modalities and their role in the post-RP and post-EBRT settings of BF. Second, we discuss the accuracy of functional and molecular imaging techniques, many of which are under investigation. Further studies are needed to establish the role of imaging techniques for detection of cancer recurrence and clinical decision-making.

Indexed as

RadiopharmaceuticalsHumansKallikreinsMaleNeoplasm Recurrence, LocalProstate-Specific AntigenProstatic NeoplasmsRadionuclide ImagingSalvage TherapyTreatment FailureKallikreinsKLK3 protein, humanProstate-Specific AntigenRadiopharmaceuticals

Identifiers

PMID24559451
PMCPMC6615465
OpenAlexW2156689647

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.