ArticleConnective tissue research2014
Topographical variations of the strain-dependent zonal properties of tibial articular cartilage by microscopic MRI.
Article in Connective tissue research, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
16 citing papers in PubMed, 27 citations in OpenAlex.
- Assessment of articular cartilage degradation in response to an impact injury using µMRI.Connective tissue research · 2024Article
- The interface region between articular cartilage and bone by μMRI and PLM at microscopic resolutions.Microscopy research and technique · 2022Article
- Topographical and zonal patterns of T2 relaxation in osteoarthritic tibial cartilage by low- and high-resolution MRI.Magnetic resonance imaging · 2021Article
- Quantitative µMRI and PLM study of rabbit humeral and femoral head cartilage at sub-10 µm resolutions.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2020Article
- Magnetic resonance imaging (MRI) studies of knee joint under mechanical loading: Review.Magnetic resonance imaging · 2020Review
- Simultaneous tractography and elastography imaging of the zone-specific structural and mechanical responses in articular cartilage under compressive loading.Biomedical optics express · 2019Article
- Quantitative measurement of T2, T1ρ and T1 relaxation times in articular cartilage and cartilage-bone interface by SE and UTE imaging at microscopic resolution.Journal of magnetic resonance (San Diego, Calif. : 1997) · 2018Article
- Functional properties of chondrocytes and articular cartilage using optical imaging to scanning probe microscopy.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2018Review
- Image interpolation improves the zonal analysis of cartilage T2 relaxation in MRI.Quantitative imaging in medicine and surgery · 2017Article
- Topographical and depth-dependent glycosaminoglycan concentration in canine medial tibial cartilage 3 weeks after anterior cruciate ligament transection surgery-a microscopic imaging study.Quantitative imaging in medicine and surgery · 2016Article
- Topographical variations in zonal properties of canine tibial articular cartilage due to early osteoarthritis: a study using 7-T magnetic resonance imaging at microscopic resolution.Magma (New York, N.Y.) · 2016Article
- The influences of different spatial resolutions on the characteristics of T2 relaxation times in articular cartilage: A coarse-graining study of the microscopic magnetic resonance imaging data.Microscopy research and technique · 2016Article
- Meniscus Induced Cartilaginous Damage and Non-linear Gross Anatomical Progression of Early-stage Osteoarthritis in a Canine Model.The open orthopaedics journal · 2016Article
- Loading-induced changes on topographical distributions of the zonal properties of osteoarthritic tibial cartilage--A study by magnetic resonance imaging at microscopic resolution.Journal of biomechanics · 2015Article
- Depth-Dependent Glycosaminoglycan Concentration in Articular Cartilage by Quantitative Contrast-Enhanced Micro-Computed Tomography.Cartilage · 2015Article
- Detection of early osteoarthritis in canine knee joints 3 weeks post ACL transection by microscopic MRI and biomechanical measurement.Journal of orthopaedic surgery (Hong Kong)Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
Abstract
The topographical variations of the zonal properties of canine articular cartilage over the medial tibia were evaluated as the function of external loading by microscopic magnetic resonance imaging (µMRI). T2 and T1 relaxation maps and GAG (glycosaminoglycan) images from a total of 70 specimens were obtained with and without the mechanical loading at 17.6 µm depth resolution. In addition, mechanical modulus and water content were measured from the tissue. For the bulk without loading, the means of T2 at magic angle (43.6 ± 8.1 ms), absolute thickness (907.6 ± 187.9 µm) and water content (63.3 ± 9.3%) on the meniscus-covered area were significantly lower than the means of T2 at magic angle (51.1 ± 8.5 ms), absolute thickness (1251.6 ± 218.4 µm) and water content (73.2 ± 5.6%) on the meniscus-uncovered area. However GAG (86.0 ± 15.3 mg/ml) on the covered area was significantly higher than GAG (70.0 ± 8.8 mg/ml) on the uncovered area. Complex relationships were found in the tissue properties as the function of external loading. The tissue parameters in the superficial zone changed more profoundly than the same properties in the radial zone. The tissue parameters in the meniscus-covered areas changed differently when comparing with the same parameters in the uncovered areas. This project confirms that the load-induced changes in the molecular distribution and structure of cartilage are both depth-dependent and topographically distributed. Such detailed knowledge of the tibial layer could improve the early detection of the subtle softening of the cartilage that will eventually lead to the clinical diseases such as osteoarthritis.
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