Evidence map›Paper›PMID 24558471›Full record

ArticlePloS one2014

The burden of nephrotoxic drug prescriptions in patients with chronic kidney disease: a retrospective population-based study in Southern Italy.

Ylenia Ingrasciotta, Janet Sultana, Francesco Giorgianni, Achille Patrizio Caputi, Vincenzo Arcoraci, Daniele Ugo Tari, Claudio Linguiti, Margherita Perrotta, Andrea Nucita, Fabio Pellegrini and 4 more

3 registry-linked trialsOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 3 registered trials, which are not on this map. Cited by 34 papers.

0numbers the graph read from it
0cells of the map it votes in
34citing papers in PubMed
3.0field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02593721 phase2 / phase3completednot on this mapstarted 2015, after this paper: background citation

Hypoalgesic Effect of Median Nerve Neural Mobilization Versus Ibuprofen Pharmacologic Treatment in Patients With Cervicobrachial Pain

TypeinterventionalSponsorUniversidad Europea de MadridRan2015 to 2015Enrolled50ConditionsCervicobrachial NeuralgiaArmsMedian Nerve Neural Mobilization, Ibuprofen
NCT02595294 nacompletednot on this mapstarted 2015, after this paper: background citation

Hypoalgesic Effect of Neural Mobilization in Cervicobrachial Pain Compared to a Controlled Group

TypeinterventionalSponsorUniversidad Europea de MadridRan2015 to 2015Enrolled52ConditionsCervicobrachial NeuralgiaArmsCervical Lateral Glide neural mobilization
NCT02596815 nacompletednot on this mapstarted 2015, after this paper: background citation

Hypoalgesic Effect of Median Nerve Neural Mobilization in Cervicobrachial Pain Compared to a Controlled Group

TypeinterventionalSponsorUniversidad Europea de MadridRan2015 to 2015Enrolled51ConditionsCervicobrachial NeuralgiaArmsMedian Nerve Neural Mobilization, Goniometer
3 · Its place in the literature

Who cites it

34 citing papers in PubMed, 76 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 3 institutions in 1 country.

Ylenia IngrasciottaDepartment of Clinical and Experimental Medicine, University of Messina, Messina, Italy.
Janet SultanaDepartment of Clinical and Experimental Medicine, University of Messina, Messina, Italy.
Francesco GiorgianniDepartment of Clinical and Experimental Medicine, University of Messina, Messina, Italy.
Achille Patrizio CaputiDepartment of Clinical and Experimental Medicine, University of Messina, Messina, Italy.
Vincenzo ArcoraciDepartment of Clinical and Experimental Medicine, University of Messina, Messina, Italy.
Daniele Ugo TariCaserta Local Health Service, Caserta, Italy.
Claudio LinguitiCaserta Local Health Service, Caserta, Italy.
Margherita PerrottaCaserta Local Health Service, Caserta, Italy.
Andrea NucitaDepartment of Cognitive Science, Educational and Cultural Studies (CSECS), University of Messina, Messina, Italy.
Fabio PellegriniUnit of Biostatistics, IRCCS "Casa Sollievo della Sofferenza", San Giovanni Rotondo (FG), Italy.
Andrea FontanaUnit of Biostatistics, IRCCS "Casa Sollievo della Sofferenza", San Giovanni Rotondo (FG), Italy.
Lorenzo CavagnaDivision of Rheumatology, University and IRCCS Foundation Policlinico S. Matteo, Pavia, Italy.
Domenico SantoroDepartment of Clinical and Experimental Medicine, University of Messina, Messina, Italy.
Gianluca TrifiròDepartment of Clinical and Experimental Medicine, University of Messina, Messina, Italy.
University of Messina · ITIstituti di Ricovero e Cura a Carattere Scientifico · ITCasa Sollievo della Sofferenza · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe use of nephrotoxic drugs can further worsening renal function in chronic kidney disease (CKD) patients. It is therefore imperative to explore prescribing practices that can negatively affect CKD patients.

aimTo analyze the use of nephrotoxic drugs in CKD patients in a general population of Southern Italy during the years 2006-2011.

methodsThe general practice "Arianna" database contains data from 158,510 persons, registered with 123 general practitioners (GPs) of Caserta. CKD patients were identified searching: CKD-related ICD-9 CM codes among causes of hospitalization; CKD-relevant procedures undergone in hospital (e.g. dialysis); drug prescriptions issued for a CKD-related indication. A list of nephrotoxic drugs was compiled and validated by pharmacologists and nephrologists. The summary of product characteristics was used to classify drugs as 'contraindicated' or 'to be used with caution' in renal diseases. Frequency of nephrotoxic drug use, overall, by drug class and single compounds, by GPs within one year prior or after first CKD diagnosis and within one year after dialysis entry was calculated.

resultsOverall, 1,989 CKD patients and 112 dialysed patients were identified. Among CKD patients, 49.8% and 45.2% received at least one prescription for a contraindicated nephrotoxic drug within one year prior or after first CKD diagnosis, respectively. In detail, 1,119 CKD patients (56.3%) had at least one nonsteroidal anti-inflammatory drugs (NSAIDs) prescription between CKD diagnosis and end of follow-up. A large proportion of CKD patients (35.6%) were treated with NSAIDs for periods exceeding 90 days. Contraindicated nephrotoxic drugs were used commonly in CKD, with nimesulide (16.6%) and diclofenac (11.0%) being most frequently used.

conclusionsContraindicated nephrotoxic drugs were highly prescribed in CKD patients from a general population of Southern Italy. CKD diagnosis did not seem to reduce significantly the prescription of nephrotoxic drugs, which may increase the risk of preventable renal function deterioration.

Indexed as

Anti-Inflammatory Agents, Non-SteroidalCohort StudiesContraindicationsDiclofenacHumansItalyKidneyMedical Records Systems, ComputerizedPrescriptionsRenal Insufficiency, ChronicRetrospective StudiesSulfonamidesAnti-Inflammatory Agents, Non-SteroidalDiclofenacnimesulideSulfonamides

Identifiers

PMID24558471
PMCPMC3928406
OpenAlexW2057917288

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.