ArticlePloS one2014
Impaired circulating CD4+ LAP+ regulatory T cells in patients with acute coronary syndrome and its mechanistic study.
Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 24 citations in OpenAlex.
- Loss of effector TNature cardiovascular research · 2025Article
- Targeting immune cell recruitment in atherosclerosis.Nature reviews. Cardiology · 2024Review
- Regulatory T-cell frequency and function in acute myocardial infarction patients and its correlation with ventricular dysfunction.Clinical and experimental immunology · 2024Article
- Regulatory T Cells in Atherosclerosis: Is Adoptive Cell Therapy Possible?Life (Basel, Switzerland) · 2023Review
- Coronary artery disease-associated immune geneFrontiers in cardiovascular medicine · 2023Article
- Construction of genetic classification model for coronary atherosclerosis heart disease using three machine learning methods.BMC cardiovascular disorders · 2022Article
- Interleukin-27 Ameliorates Atherosclerosis in ApoEMediators of inflammation · 2022Article
- Periodontitis is associated to increased systemic inflammation in postmyocardial infarction patients.Open heart · 2021Article
- Immunobiology of Atherosclerosis: A Complex Net of Interactions.International journal of molecular sciences · 2019Review
- Association between the level of CD4Journal of geriatric cardiology : JGC · 2018Article
- Intracellular and extracellular TGF-β signaling in cancer: some recent topics.Frontiers of medicine · 2018Review
- Regulatory T cells as a new therapeutic target for atherosclerosis.Acta pharmacologica Sinica · 2018Review
- CD4Immunology · 2017Article
- Intranasal immunization with heat shock protein 60 induces CD4(+) CD25(+) GARP(+) and type 1 regulatory T cells and inhibits early atherosclerosis.Clinical and experimental immunology · 2016Article
- Article
- Treating atherosclerosis with regulatory T cells.Arteriosclerosis, thrombosis, and vascular biology · 2015Review
Corrections and comments
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Authors and funding
13 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveCD4(+) latency-associated peptide (LAP)(+) regulatory T cells (Tregs) are a newly discovered T cell subset in humans and the role of these cells in patients with acute coronary syndrome (ACS) has not been explored. We designed to investigate whether circulating frequency and function of CD4(+)LAP(+) Tregs are defective in ACS.
methodsOne hundred eleven ACS patients (acute myocardial infarction and unstable angina) and 117 control patients were enrolled in the study. The control patients consisted of chronic stable angina (CSA) and chest pain syndrome (CPS). The frequencies of circulating CD4(+)LAP(+) Tregs and the expression of the transmembrane protein glycoprotein-A repetitions predominant (GARP) on CD4(+) T cells were determined by flow cytometry. The function of CD4(+)LAP(+) Tregs was detected using thymidine uptake. Serum interleukin-10 (IL-10) and transforming growth factor-β protein (TGF-β) levels were detected using ELISA and expression of GARP mRNA in peripheral blood mononuclear cells (PBMCs) was measured by real time-polymerase chain reaction.
resultsWe found ACS patients had a significantly lower frequency of circulating CD4(+)LAP(+) Tregs, and the function of these cells was reduced compared to controls. The expression of GARP in CD4(+) T cells and the serum levels of TGF-β in ACS patients were lower than those of control patients. The serum levels of IL-10 were similar between the two cohorts.
conclusionsA novel regulatory T cell subset, defined as CD4(+)LAP(+) T cells is defective in ACS patients.
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