Evidence map›Paper›PMID 24558416›Full record

SynthesisPloS one2014

Job strain and the risk of inflammatory bowel diseases: individual-participant meta-analysis of 95,000 men and women.

Katriina Heikkilä, Ida E H Madsen, Solja T Nyberg, Eleonor I Fransson, Kirsi Ahola, Lars Alfredsson, Jakob B Bjorner, Marianne Borritz, Hermann Burr, Nico Dragano and 22 more

Open access · goldAbstract readMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 2 pooled it
1.9field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 2 syntheses or guidelines pooled it, 23 citations in OpenAlex.

  1. Risk factors for inflammatory bowel disease: an umbrella review.Frontiers in cellular and infection microbiology · 2024
    Pooled it
  2. Pooled it
  3. Environmental risk factors for inflammatory bowel disease.United European gastroenterology journal · 2022
    Review
  4. Review
  5. Article
  6. Review
  7. Ulcerative colitis.Lancet (London, England) · 2017
    Review
  8. Review
  9. The epidemiology and risk factors of inflammatory bowel disease.International journal of clinical and experimental medicine · 2015
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

32 authors at 18 institutions in 6 countries.

Katriina HeikkiläFinnish Institute of Occupational Health, Helsinki, Finland.
Ida E H MadsenNational Research Centre for the Working Environment, Copenhagen, Denmark.
Solja T NybergFinnish Institute of Occupational Health, Helsinki, Finland.
Eleonor I FranssonInstitute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden ; School of Health Sciences, Jönköping University, Jönköping, Sweden ; Stress Research Institute, Stockholm University, Stockholm, Sweden.
Kirsi AholaFinnish Institute of Occupational Health, Helsinki, Finland.
Lars AlfredssonInstitute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.
Jakob B BjornerNational Research Centre for the Working Environment, Copenhagen, Denmark.
Marianne BorritzDepartment of Occupational and Environmental Medicine, Bispebjerg University Hospital, Copenhagen, Denmark.
Hermann BurrFederal Institute for Occupational Safety and Health (BAuA), Berlin, Germany.
Nico DraganoInstitute for Medical Sociology, Medical Faculty, University of Düsseldorf, Düsseldorf, Germany.
Jane E FerrieSchool of Community and Social Medicine, University of Bristol, Bristol, United Kingdom ; Department of Epidemiology and Public Health, University College London, London, United Kingdom.
Anders KnutssonDepartment of Health Sciences, Mid Sweden University, Sundsvall, Sweden.
Markku KoskenvuoDepartment of Public Health, University of Helsinki, Helsinki, Finland.
Aki KoskinenFinnish Institute of Occupational Health, Helsinki, Finland.
Martin L NielsenDepartment of Occupational and Environmental Medicine, Bispebjerg University Hospital, Copenhagen, Denmark.
Maria NordinDepartment of Psychology, Umeå University, Umeå, Sweden.
Jan H PejtersenThe Danish National Centre for Social Research, Copenhagen, Denmark.
Jaana PenttiFinnish Institute of Occupational Health, Helsinki, Tampere and Turku, Finland.
Reiner RuguliesNational Research Centre for the Working Environment, Copenhagen, Denmark ; Department of Public Health and Department of Psychology, University of Copenhagen, Copenhagen, Denmark.
Tuula OksanenFinnish Institute of Occupational Health, Helsinki, Tampere and Turku, Finland.
Martin J ShipleyDepartment of Epidemiology and Public Health, University College London, London, United Kingdom.
Sakari B SuominenFolkhälsan Research Center, Helsinki, Finland ; Department of Public Health, University of Turku, Turku, Finland ; Nordic School of Public Health, Göteborg, Sweden.
Töres TheorellStress Research Institute, Stockholm University, Stockholm, Sweden.
Ari VäänänenFinnish Institute of Occupational Health, Helsinki, Finland.
Jussi VahteraFinnish Institute of Occupational Health, Helsinki, Tampere and Turku, Finland ; Department of Public Health, University of Turku, Turku, Finland.
Marianna VirtanenFinnish Institute of Occupational Health, Helsinki, Finland.
Hugo WesterlundStress Research Institute, Stockholm University, Stockholm, Sweden.
Peter J M WesterholmOccupational and Environmental Medicine, Uppsala University, Uppsala, Sweden.
G David BattyDepartment of Epidemiology and Public Health, University College London, London, United Kingdom ; Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edingurgh, United Kingdom.
Archana Singh-ManouxDepartment of Epidemiology and Public Health, University College London, London, United Kingdom ; Inserm U1018, Centre for Research in Epidemiology and Population Health, Villejuif, France.
Mika KivimäkiFinnish Institute of Occupational Health, Helsinki, Finland ; Department of Epidemiology and Public Health, University College London, London, United Kingdom.
IPD-Work Consortium
Finnish Institute of Occupational Health · FIStockholm University · SEBispebjerg Hospital · DKNational Research Centre for the Working Environment · DKAlzheimer Scotland · GBDanish National Centre for Social Research · DKFederal Institute for Occupational Safety and Health · DEHeinrich Heine University Düsseldorf · DEInserm · FRKarolinska Institutet · SEMid Sweden University · SEUmeå University · SEUniversity College London · GBUniversity of Bristol · GBUniversity of Copenhagen · DKUniversity of Helsinki · FIUniversity of Turku · FIUppsala University · SE

Funding

Socioeconomic gradient in CHD in early old ageR01HL036310 · NHLBI · UNIVERSITY OF LONDON · PI KIVIMAKI, MIKA J, MARMOT, MICHAEL G · 1986 to 2012
$3.1M
Health behaviors over the adult lifecourse and cognitive agingR01AG034454 · NIA · UNIVERSITY COLLEGE LONDON · PI KIVIMAKI, MIKA J, SINGH-MANOUX, ARCHANA · 2009 to 2013
$1.5M
British Heart FoundationMedical Research Council K013351Medical Research Council MR/K013351/1NHLBI NIH HHS R01 HL036310NHLBI NIH HHS R01HL036310NIA NIH HHS R01 AG034454NIA NIH HHS R01AG034454
6 · The paper itself

Abstract

BACKGROUND AND

aimsMany clinicians, patients and patient advocacy groups believe stress to have a causal role in inflammatory bowel diseases, such as Crohn's disease and ulcerative colitis. However, this is not corroborated by clear epidemiological research evidence. We investigated the association between work-related stress and incident Crohn's disease and ulcerative colitis using individual-level data from 95,000 European adults.

methodsWe conducted individual-participant data meta-analyses in a set of pooled data from 11 prospective European studies. All studies are a part of the IPD-Work Consortium. Work-related psychosocial stress was operationalised as job strain (a combination of high demands and low control at work) and was self-reported at baseline. Crohn's disease and ulcerative colitis were ascertained from national hospitalisation and drug reimbursement registers. The associations between job strain and inflammatory bowel disease outcomes were modelled using Cox proportional hazards regression. The study-specific results were combined in random effects meta-analyses.

resultsOf the 95,379 participants who were free of inflammatory bowel disease at baseline, 111 men and women developed Crohn's disease and 414 developed ulcerative colitis during follow-up. Job strain at baseline was not associated with incident Crohn's disease (multivariable-adjusted random effects hazard ratio: 0.83, 95% confidence interval: 0.48, 1.43) or ulcerative colitis (hazard ratio: 1.06, 95% CI: 0.76, 1.48). There was negligible heterogeneity among the study-specific associations.

conclusionsOur findings suggest that job strain, an indicator of work-related stress, is not a major risk factor for Crohn's disease or ulcerative colitis.

Indexed as

Stress, PsychologicalFemaleHumansInflammatory Bowel DiseasesMaleRiskWork

Identifiers

PMID24558416
PMCPMC3928274
OpenAlexW2168922046

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.