Evidence map›Paper›PMID 24558405›Full record

Trial reportPloS one2014

Reduction of death rate due to acute myocardial infarction in subjects with cancers through systemic restoration of impaired nitric oxide.

Rajeshwary Ghosh, Udayan Ray, Pradipta Jana, Rabindra Bhattacharya, Debipriya Banerjee, Asru Sinha

Open access · goldAbstract readClinical Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.6field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 12 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
  4. Article
  5. Review
  6. Day/Night and Summer/Winter Changes in Serum Total Antioxidant Capacity.Medicinal chemistry (Shariqah (United Arab Emirates)) · 2018
    Article
  7. Article
  8. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 2 countries.

Rajeshwary GhoshSinha Institute of Medical Science and Technology, Kolkata, India.
Udayan RayRoyal Hobart Hospital, University of Tasmania, Australia.
Pradipta JanaSinha Institute of Medical Science and Technology, Kolkata, India.
Rabindra BhattacharyaKalyani Gandhi Memorial Hospital, West Bengal, India.
Debipriya BanerjeeSinha Institute of Medical Science and Technology, Kolkata, India.
Asru SinhaSinha Institute of Medical Science and Technology, Kolkata, India.
Sinha Institute of Medical Science & Technology · INRoyal Hobart Hospital · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionExcessive aggregation of platelets at the site of plaque rupture on the coronary artery led to the formation of thrombus which is reported to precipitate acute myocardial infarction (AMI). Nitric oxide (NO) has been reported to inhibit platelet aggregation and induce thrombolysis through the in situ formation of plasmin. As the plasma NO level in AMI patients from two different ethnic groups was reduced to 0 µM (median) compared to 4.0 µM (median) in normal controls, the effect of restoration of the NO level to normal ranges on the rate of death due to AMI was determined. METHODS AND

resultsThe restoration of plasma NO level was achieved by a sticking small cotton pad (10×25 mm) containing 0.28 mmol sodium nitroprusside (SNP) in 0.9% NaCl to the abdominal skin of the participants using non-toxic adhesive tape which was reported to normalize the plasma NO level. The participants (8,283) were volunteers in an independent study who had different kinds of cancers and did not wish to use any conventional therapy for their condition but opted to receive SNP "pad" for their condition for 3 years. The use of SNP "pad" which normalized (≈4.0 µM) the plasma NO level that in consequence reduced the death rate due to AMI, among the participants, was found to be significantly reduced compared to the death due to AMI in normal population.

conclusionOur data suggested that the use of SNP "pad" significantly reduced the death due to AMI.

trial registrationwww.ctri.nic.in CTRI/2013/12/004236.

Indexed as

Adenosine DiphosphateAgedAged, 80 and overCase-Control StudiesCoronary ThrombosisFemaleHumansMaleMiddle AgedMyocardial InfarctionNeoplasmsNitric OxideNitroprussidePeptidesAdenosine DiphosphatedermcidinNitric OxideNitroprussidePeptides

Identifiers

PMID24558405
PMCPMC3928291
OpenAlexW2060403495

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.