ArticlePLoS medicine2014
Living systematic reviews: an emerging opportunity to narrow the evidence-practice gap.
Article in PLoS medicine, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 227 papers, 43 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
227 citing papers in PubMed, 43 syntheses or guidelines pooled it.
- Mapping global inequities in telemedicine implementation: An umbrella review of barriers and facilitators.PloS one · 2026Pooled it
- Operationalization of Artificial Intelligence Applications in the Intensive Care Unit: A Systematic Review.JAMA network open · 2025Pooled it
- Advancing genetic counselling in Southern Africa: Unveiling opportunities for inclusive healthcare and genomic education for Angola.Saudi medical journal · 2025Pooled it
- Pooled it
- Systematic online living evidence summaries: emerging tools to accelerate evidence synthesis.Clinical science (London, England : 1979) · 2023Pooled it
- First-line therapy for adults with advanced renal cell carcinoma: a systematic review and network meta-analysis.The Cochrane database of systematic reviews · 2023Pooled it
- Plyometric-Jump Training Effects on Physical Fitness and Sport-Specific Performance According to Maturity: A Systematic Review with Meta-analysis.Sports medicine - open · 2023Pooled it
- The role of smoking in COVID-19 progression: a comprehensive meta-analysis.European respiratory review : an official journal of the European Respiratory Society · 2023Pooled it
- Effectiveness of Conservative Interventions After Acute Hamstrings Injuries in Athletes: A Living Systematic Review.Sports medicine (Auckland, N.Z.) · 2023Pooled it
- Past, present and future of living systematic review: a bibliometrics analysis.BMJ global health · 2022Pooled it
- The Cooperation Databank: Machine-Readable Science Accelerates Research Synthesis.Perspectives on psychological science : a journal of the Association for Psychological Science · 2022Pooled it
- Effect of Attentional Focus on Sprint Performance: A Meta-Analysis.International journal of environmental research and public health · 2022Pooled it
- Occurrence and transmission potential of asymptomatic and presymptomatic SARS-CoV-2 infections: Update of a living systematic review and meta-analysis.PLoS medicine · 2022Pooled it
- Hydroxychloroquine in the treatment of coronavirus disease 2019: Rapid updated systematic review and meta-analysis.Reviews in medical virology · 2022Pooled it
- Longitudinal outcome evaluations of Interdisciplinary Multimodal Pain Treatment programmes for patients with chronic primary musculoskeletal pain: A systematic review and meta-analysis.European journal of pain (London, England) · 2022Pooled it
- International alliance and AGREE-ment of 71 clinical practice guidelines on the management of critical care patients with COVID-19: a living systematic review.Journal of clinical epidemiology · 2022Pooled it
- Pooled it
- A systematic review of the associations between care home ownership and COVID-19 outbreaks, infections and mortality.Nature aging · 2021Pooled it
- The Chagas disease study landscape: A systematic review of clinical and observational antiparasitic treatment studies to assess the potential for establishing an individual participant-level data platform.PLoS neglected tropical diseases · 2021Pooled it
- Identifying Novel Biomarkers Ready for Evaluation in Low-Prevalence Populations for the Early Detection of Lower Gastrointestinal Cancers: A Systematic Review and Meta-Analysis.Advances in therapy · 2021Pooled it
167 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
Abstract
The current difficulties in keeping systematic reviews up to date leads to considerable inaccuracy, hampering the translation of knowledge into action. Incremental advances in conventional review updating are unlikely to lead to substantial improvements in review currency. A new approach is needed. We propose living systematic review as a contribution to evidence synthesis that combines currency with rigour to enhance the accuracy and utility of health evidence. Living systematic reviews are high quality, up-to-date online summaries of health research, updated as new research becomes available, and enabled by improved production efficiency and adherence to the norms of scholarly communication. Together with innovations in primary research reporting and the creation and use of evidence in health systems, living systematic review contributes to an emerging evidence ecosystem.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.