ArticleGenome biology and evolution2014
Complete dosage compensation and sex-biased gene expression in the moth Manduca sexta.
Article in Genome biology and evolution, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
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38 citing papers in PubMed, 67 citations in OpenAlex.
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- HJ Muller and the Relationship Between Sex Chromosome Degeneration and the Evolution of Dosage Compensation.Genome biology and evolution · 2025Review
- Elucidating the Molecular Mechanisms of Sex Ratio Distortion Mediated by Cytoplasmic Symbionts.Genome biology and evolution · 2025Review
- Sex-Biased Gene Expression of RNAi Pathway Components in the Sea Lice Caligus rogercresseyi.Marine biotechnology (New York, N.Y.) · 2025Article
- Sex Chromosome Dosage Compensation in Insects.Insects · 2025Review
- RNA sequencing analysis of sexual dimorphism in Japanese quail.Frontiers in veterinary science · 2024Article
- Chromatin accessibility, not 5mC methylation covaries with partial dosage compensation in crows.PLoS genetics · 2023Article
- Diverse Molecular Mechanisms Underlying Microbe-Inducing Male Killing in the Moth Homona magnanima.Applied and environmental microbiology · 2023Article
- Masculinizer-induced dosage compensation is achieved by transcriptional downregulation of both copies of Z-linked genes in the silkworm,Biology letters · 2022Article
- Dosage compensation inProceedings of the National Academy of Sciences of the United States of America · 2022Article
- Support for faster and more adaptive Z chromosome evolution in two divergent lepidopteran lineagesEvolution; international journal of organic evolution · 2022Article
- Thermosensitive sex chromosome dosage compensation in ZZ/ZW softshell turtles,Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2021Article
- A de novo transcriptional atlas in Danaus plexippus reveals variability in dosage compensation across tissues.Communications biology · 2021Article
- Transcriptomics reveals specific molecular mechanisms underlying transgenerational immunity inEcology and evolution · 2020Article
- Sexual dimorphism and sex-biased gene expression in an egg parasitoid species, Anastatus disparis.BMC genomics · 2020Article
- Sex Chromosome Evolution: So Many Exceptions to the Rules.Genome biology and evolution · 2020Review
- Dichotomy of Dosage Compensation along the Neo Z Chromosome of the Monarch Butterfly.Current biology : CB · 2019Article
- Regional epigenetic differentiation of the Z Chromosome between sexes in a female heterogametic system.Genome research · 2019Article
- Multilayered Tuning of Dosage Compensation and Z-Chromosome Masculinization in the Wood White (Leptidea sinapis) Butterfly.Genome biology and evolution · 2019Article
- Evolution of Phototransduction Genes in Lepidoptera.Genome biology and evolution · 2019Article
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Sex chromosome dosage compensation balances homogametic sex chromosome expression with autosomal expression in the heterogametic sex, leading to sex chromosome expression parity between the sexes. If compensation is incomplete, this can lead to expression imbalance and sex-biased gene expression. Recent work has uncovered an intriguing and variable pattern of dosage compensation across species that includes a lack of complete dosage compensation in ZW species compared with XY species. This has led to the hypothesis that ZW species do not require complete compensation or that complete compensation would negatively affect their fitness. To date, only one study, a study of the moth Bombyx mori, has discovered evidence for complete dosage compensation in a ZW species. We examined another moth species, Manduca sexta, using high-throughput sequencing to survey gene expression in the head tissue of males and females. We found dosage compensation to be complete in M. sexta with average expression between the Z chromosome in males and females being equal. When genes expressed at very low levels are removed by filtering, we found that average autosome expression was highly similar to average Z expression, suggesting that the majority of genes in M. sexta are completely dosage compensated. Further, this compensation was accompanied by sex-specific gene expression associated with important sexually dimorphic traits. We suggest that complete dosage compensation in ZW species might be more common than previously appreciated and linked to additional selective processes, such as sexual selection. More ZW and lepidopteran species should now be examined in a phylogenetic framework, to understand the evolution of dosage compensation.
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