ArticleAnnals of surgical oncology2014
Management of local recurrence of pediatric osteosarcoma following limb-sparing surgery.
Article in Annals of surgical oncology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 26 citations in OpenAlex.
- Near-Infrared Imaging Using a Cathepsin-Targeted, Quenched Activity-Based Probe Identifies Naturally Occurring Canine Appendicular Osteosarcoma.Clinical cancer research : an official journal of the American Association for Cancer Research · 2026Article
- Hydrogel delivering antifibrotic agent and nano-sonosensitizer enhances efficacy of sonodynamic therapy in osteosarcoma treatment.Bioactive materials · 2026Article
- A decision tree model suggests a strong interaction effect between tumor size and a close surgical margin on the prognosis of limb salvage surgery in high-grade osteosarcoma.Frontiers in surgery · 2026Article
- Research Progress on the Evaluation and Clinical Value of Negative Surgical Margins in Osteosarcoma.Orthopedic research and reviews · 2026Review
- Chondroblastic Subtype Is Associated with Higher Rates of Local Recurrence in Skeletal Osteosarcoma.Journal of clinical medicine · 2025Article
- Comprehensive surgical and reconstructive management with in-depth complication analysis of giant pediatric sarcomas: a two-center tertiary experience.European journal of orthopaedic surgery & traumatology : orthopedie traumatologie · 2025Article
- The application of custom 3D-printed prostheses with ultra-short stems in the reconstruction of bone defects: a single center analysis.Frontiers in bioengineering and biotechnology · 2024Article
- Nano-Based Drug Delivery Systems: Potential Developments in the Therapy of Metastatic Osteosarcoma-A Narrative Review.Pharmaceutics · 2023Review
- Advances in 3D-Printed Surface-Modified Ca-Si Bioceramic Structures and Their Potential for Bone Tumor Therapy.Materials (Basel, Switzerland) · 2021Review
- Guideline for Limb-Salvage Treatment of Osteosarcoma.Orthopaedic surgery · 2020Article
- Cadmium in bone cement induces necrosis and decreases the viability of residual osteosarcoma cells: A xenograft study.Acta orthopaedica et traumatologica turcica · 2020Article
- Tumor Resection Guided by Intraoperative Indocyanine Green Dye Fluorescence Angiography Results in Negative Surgical Margins and Decreased Local Recurrence in an Orthotopic Mouse Model of Osteosarcoma.Annals of surgical oncology · 2019Article
- Role of Amputation in Improving Mobility, Pain Outcomes, and Emotional and Psychological Well-Being in Children With Metastatic Osteosarcoma.The American journal of hospice & palliative care · 2019Article
- Risk factors for surgical site infection after malignant bone tumor resection and reconstruction.BMC cancer · 2019Article
- Checkpoint kinase inhibitor AZD7762 enhance cisplatin-induced apoptosis in osteosarcoma cells.Cancer cell international · 2019Article
- Magnetic resonance imaging features for the differential diagnosis of local recurrence of bone sarcoma after prosthesis replacement.Journal of orthopaedic translation · 2018Article
- FDG PET/CT appearance of local osteosarcoma recurrences in pediatric patients.Pediatric radiology · 2017Article
- Upper extremity sarcoma: impact of current practice guidelines and controversies on reconstructive approaches.SICOT-J · 2017Article
- Antitumor activity of dobutamine on human osteosarcoma cells.Oncology letters · 2016Article
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundThe optimal management of locally recurrent pediatric osteosarcoma is not established, especially after prior limb-sparing surgery. We describe our experience in the management of these patients and identify prognostic indicators of post-recurrence survival.
methodsWe conducted a retrospective, single-institution review of patients with locally recurrent osteosarcoma after limb-salvage surgery who were treated between October 1989 and January 2012. The management of each recurrence was evaluated, and patient, disease, and treatment factors were correlated with post-recurrence survival (PRS).
resultsOf 200 patients who underwent limb-sparing procedures, 18 (9 %) had biopsy-proven local recurrence. Recurrences occurred in soft tissue in 15 patients (83.3 %). Six patients (33.3 %) were amenable to repeat limb-sparing surgery. Median time to local recurrence was 1.4 (range 0.6-10.4) years. Median PRS was 11.8 months (range 3.7 months-12.1 years). Post-recurrence survival was significantly associated with the length of resection margins and was longer when recurrent tumors were resected with margins of ≥1 cm, compared with subcentimeter or positive margins (P = 0.03). Median PRS was longer in patients who underwent amputations (2.44 years) than those who underwent repeat limb-sparing surgery (0.86 years), and in patients who had distant metastases resected (2.7 years) than those who did not (0.85 years); however, differences were not significant.
conclusionsLocal management of recurrent osteosarcoma in a previously reconstructed limb is highly individualized. A sufficiently wide resection is important for local control of recurrences, independent of the type of surgery. Maintaining control of distant metastases may also contribute to improved survival.
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