ArticleJournal of the Association for Research in Otolaryngology : JARO2014
I h and HCN channels in murine spiral ganglion neurons: tonotopic variation, local heterogeneity, and kinetic model.
Article in Journal of the Association for Research in Otolaryngology : JARO, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 28 citations in OpenAlex.
- A comprehensive review of HCN channel expression and IJournal of neurophysiology · 2025Review
- Chromatin remodeling protein CHD4 regulates axon guidance of spiral ganglion neurons in the developing cochlea.bioRxiv : the preprint server for biology · 2025Article
- Expression of hyperpolarization-activated current (Journal of neurophysiology · 2023Article
- Modulation of potassium conductances optimizes fidelity of auditory information.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Amplification of input differences by dynamic heterogeneity in the spiral ganglion.Journal of neurophysiology · 2022Article
- Dynamic Heterogeneity Shapes Patterns of Spiral Ganglion Activity.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- Analog transmission of action potential fine structure in spiral ganglion axons.Journal of neurophysiology · 2021Article
- Encoding sound in the cochlea: from receptor potential to afferent discharge.The Journal of physiology · 2021Review
- HCN channels in the mammalian cochlea: Expression pattern, subcellular location, and age-dependent changes.Journal of neuroscience research · 2021Article
- Simulated auditory fiber myelination heterogeneity desynchronizes population responses to electrical stimulation limiting inter-aural timing difference representation.The Journal of the Acoustical Society of America · 2021Article
- Article
- Enhanced Activation of HCN Channels Reduces Excitability and Spike-Timing Regularity in Maturing Vestibular Afferent Neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2019Article
- A biophysical modelling platform of the cochlear nucleus and other auditory circuits: From channels to networks.Hearing research · 2018Article
- Models of utricular bouton afferents: role of afferent-hair cell connectivity in determining spike train regularity.Journal of neurophysiology · 2017Article
- Predictions of the Contribution of HCN Half-Maximal Activation Potential Heterogeneity to Variability in Intrinsic Adaptation of Spiral Ganglion Neurons.Journal of the Association for Research in Otolaryngology : JARO · 2017Article
- Genetic perturbations suggest a role of the resting potential in regulating the expression of the ion channels of the KCNA and HCN families in octopus cells of the ventral cochlear nucleus.Hearing research · 2017Article
- Accumulation of KThe Journal of physiology · 2017Article
- Organ of Corti explants direct tonotopically graded morphology of spiral ganglion neurons in vitro.The Journal of comparative neurology · 2016Article
- Maturation of NaV and KV Channel Topographies in the Auditory Nerve Spike Initiator before and after Developmental Onset of Hearing Function.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2016Article
- Temporal Considerations for Stimulating Spiral Ganglion Neurons with Cochlear Implants.Journal of the Association for Research in Otolaryngology : JARO · 2016Review
Corrections and comments
- Erratum issued
Authors and funding
3 authors at 3 institutions in 1 country.
Funding
Abstract
One of the major contributors to the response profile of neurons in the auditory pathways is the I h current. Its properties such as magnitude, activation, and kinetics not only vary among different types of neurons (Banks et al., J Neurophysiol 70:1420-1432, 1993; Fu et al., J Neurophysiol 78:2235-2245, 1997; Bal and Oertel, J Neurophysiol 84:806-817, 2000; Cao and Oertel, J Neurophysiol 94:821-832, 2005; Rodrigues and Oertel, J Neurophysiol 95:76-87, 2006; Yi et al., J Neurophysiol 103:2532-2543, 2010), but they also display notable diversity in a single population of spiral ganglion neurons (Mo and Davis, J Neurophysiol 78:3019-3027, 1997), the first neural element in the auditory periphery. In this study, we found from somatic recordings that part of the heterogeneity can be attributed to variation along the tonotopic axis because I h in the apical neurons have more positive half-activation voltage levels than basal neurons. Even within a single cochlear region, however, I h current properties are not uniform. To account for this heterogeneity, we provide immunocytochemical evidence for variance in the intracellular density of the hyperpolarization-activated cyclic nucleotide-gated channel α-subunit 1 (HCN1), which mediates I h current. We also observed different combinations of HCN1 and HCN4 α-subunits from cell to cell. Lastly, based on the physiological data, we performed kinetic analysis for the I h current and generated a mathematical model to better understand varied I h on spiral ganglion function. Regardless of whether I h currents are recorded at the nerve terminals (Yi et al., J Neurophysiol 103:2532-2543, 2010) or at the somata of spiral ganglion neurons, they have comparable mean half-activation voltage and induce similar resting membrane potential changes, and thus our model may also provide insights into the impact of I h on synaptic physiology.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.