ArticleThe Journal of biological chemistry2014
Introduction of a synthetic CO₂-fixing photorespiratory bypass into a cyanobacterium.
Article in The Journal of biological chemistry, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
31 citing papers in PubMed, 97 citations in OpenAlex.
- Extending the Farquhar-von Caemmerer-Berry photosynthesis model to account for various photorespiratory bypasses.The New phytologist · 2026Article
- Shortcutting photorespiration: avenues and challenges toward realizing higher-yielding photorespiratory bypass crops.The New phytologist · 2026Review
- Structural Basis for a Cork-Up Mechanism of the Intra-Molecular Mesaconyl-CoA Transferase.Biochemistry · 2023Article
- Emerging Trends in Genetic Engineering of Microalgae for Commercial Applications.Marine drugs · 2022Review
- Synthetic Biology Approaches for Improving Chemical Production in Cyanobacteria.Frontiers in bioengineering and biotechnology · 2022Review
- Biosynthetic approaches to efficient assimilation of COFrontiers in bioengineering and biotechnology · 2022Review
- Impairing photorespiration increases photosynthetic conversion of COBioresources and bioprocessing · 2021Article
- Genetic, Genomics, and Responses to Stresses in Cyanobacteria: Biotechnological Implications.Genes · 2021Review
- Recent Advances in the Photoautotrophic Metabolism of Cyanobacteria: Biotechnological Implications.Life (Basel, Switzerland) · 2020Review
- A wish list for synthetic biology in photosynthesis research.Journal of experimental botany · 2020Article
- Expression of Formate-Tetrahydrofolate Ligase Did Not Improve Growth but Interferes With Nitrogen and Carbon Metabolism ofFrontiers in microbiology · 2020Article
- Increased ethylene production by overexpressing phosphoenolpyruvate carboxylase in the cyanobacteriumBiotechnology for biofuels · 2020Article
- Synthetic biology approaches for improving photosynthesis.Journal of experimental botany · 2019Review
- Update: Improving the Efficiency of Photosynthetic Carbon Reactions.Plant physiology · 2019Review
- Back to the future: Why we need enzymology to build a synthetic metabolism of the future.Beilstein journal of organic chemistry · 2019Review
- Photoreduction of COJournal of the American Chemical Society · 2018Article
- Design and in vitro realization of carbon-conserving photorespiration.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
- Assimilation of formic acid and COProceedings of the National Academy of Sciences of the United States of America · 2018Article
- A short history of RubisCO: the rise and fall (?) of Nature's predominant COCurrent opinion in biotechnology · 2018Review
- Evolution of the 3-hydroxypropionate bicycle and recent transfer of anoxygenic photosynthesis into the Chloroflexi.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
Corrections and comments
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Authors and funding
4 authors at 4 institutions in 1 country.
Funding
Abstract
Global photosynthetic productivity is limited by the enzymatic assimilation of CO2 into organic carbon compounds. Ribulose-1,5-bisphosphate carboxylase/oxygenase (RuBisCO), the carboxylating enzyme of the Calvin-Benson cycle, poorly discriminates between CO2 and O2, leading to photorespiration and the loss of fixed carbon and nitrogen. With the advent of synthetic biology, it is now feasible to design, synthesize, and introduce biochemical pathways in vivo. We engineered a synthetic photorespiratory bypass based on the 3-hydroxypropionate bi-cycle into the model cyanobacterium, Synechococcus elongatus sp. PCC 7942. The heterologously expressed cycle is designed to function as both a photorespiratory bypass and an additional CO2-fixing pathway, supplementing the Calvin-Benson cycle. We demonstrate the function of all six introduced enzymes and identify bottlenecks to be targeted in subsequent bioengineering. These results have implications for efforts to improve photosynthesis and for the "green" production of high value products of biotechnological interest.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.