ArticleJournal of natural medicines2014
Bioactivities of alcohol based extracts of Phyllanthus emblica branches: antioxidation, antimelanogenesis and anti-inflammation.
Article in Journal of natural medicines, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 48 citations in OpenAlex.
- A Randomized Double-Blind Controlled Evaluation of the Therapeutic Benefits of an Herbal Lip Hydrant.Journal of cosmetic dermatology · 2025Trial
- Transdermal delivery and anti-inflammatory efficacy of Mitragyna speciosa extract transdermal patch for local inflammation management: in vitro, ex vivo, and in vivo investigations.Drug delivery and translational research · 2026Article
- Research on the pathogen causing root rot onFrontiers in microbiology · 2025Article
- Anti-Inflammatory and Antimicrobial Effects of Herbal Formulation Called Apo-Taat Using Extended-Spectrum ß-Lactamase-ProducingTheScientificWorldJournal · 2025Article
- The Potential Health Benefits of Gallic Acid: Therapeutic and Food Applications.Antioxidants (Basel, Switzerland) · 2024Review
- Gallic acid attenuates LPS-induced inflammation in Caco-2 cells by suppressing the activation of the NF-κB/MAPK signaling pathway.Acta biochimica et biophysica Sinica · 2024Article
- Anti-inflammatory potential of turmeric, amla, and black pepper mixture against sepsis-induced acute lung injury in rats.Journal of food science and technology · 2023Article
- The Modulation of Melanogenesis in B16 Cells Upon Treatment with Plant Extracts and Isolated Plant Compounds.Molecules (Basel, Switzerland) · 2022Review
- Tandem mass tag-based proteomics analysis reveals the multitarget mechanisms ofFrontiers in pharmacology · 2022Article
- Serum Metabolomics Analysis of the Anti-Inflammatory Effects of Gallic Acid on Rats With Acute Inflammation.Frontiers in pharmacology · 2022Article
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- Hepatoprotective Effect and Potential Mechanism of Aqueous Extract fromEvidence-based complementary and alternative medicine : eCAM · 2021Article
- Assessment of the Cytotoxic Activity of Triphala: A Semisolid Traditional Formulation on HepGBioMed research international · 2021Article
- Bioactivity-guided isolation of anti-inflammatory components fromFood science & nutrition · 2020Article
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- Anti-inflammatory Effects of Phyllanthus emblica L on Benzopyrene-Induced Precancerous Lung Lesion by Regulating the IL-1β/miR-101/Lin28B Signaling Pathway.Integrative cancer therapies · 2017Article
- Systematic Overview of Bacopa monnieri (L.) Wettst. Dominant Poly-Herbal Formulas in Children and Adolescents.Medicines (Basel, Switzerland) · 2017Review
- Exploratory studies on the therapeutic effects of Kumarabharana Rasa in the management of chronic tonsillitis among children at a tertiary care hospital of Karnataka.Journal of traditional and complementary medicine · 2016Article
- Phyllanthus emblica leaf extract ameliorates testicular damage in rats with chronic stress.Journal of Zhejiang University. Science. BArticle
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Phyllanthus emblica is an euphorbiaceous plant that has long been used in traditional medicines for health promotion, anti-aging and also for treatment of wide ranges of symptoms and diseases. The aim of this study is to investigate the pharmacological activity of the plant branch. Alcohol based extracts of P. emblica branch were prepared in 50 % ethanolic extract by maceration (EPE) and methanolic extract by Soxhlet apparatus (MPE). EPE and MPE contained high total phenolic content and strong antioxidative activity. By HPLC analysis, gallic acid and vanillic acid are the major phenolic compounds of these extracts. Both EPE and MPE inhibited tyrosinase activity stronger than the ethanolic extract of P. emblica fruit (IC50 of 247.37 ± 18.57 and 193.75 ± 44.90 versus 4346.95 ± 166.23 μg/ml). EPE significantly inhibited the mRNA expressions of tyrosinase, and tyrosinase related proteins (TRP-1 and TRP-2) in B16 murine melanoma cells and suppressed the expression of LPS-induced pro-inflammatory genes (COX-2, iNOS, TNF-α, IL-16 and IL-6) in RAW 264.7 murine macrophage cells in a dose-dependent manner. These extracts significantly suppressed the carrageenan-induced paw edema in rats in a dose-dependent manner.
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