ArticleJournal of applied physiology (Bethesda, Md. : 1985)2014
Thin-beam ultrasound overestimation of blood flow: how wide is your beam?
Article in Journal of applied physiology (Bethesda, Md. : 1985), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
26 citing papers in PubMed, 29 citations in OpenAlex.
- Histamine is a molecular transducer of adaptation to endurance exercise training in humans.Journal of applied physiology (Bethesda, Md. : 1985) · 2025Trial
- Age Modulates Physiological Responses during Fan Use under Extreme Heat and Humidity.Medicine and science in sports and exercise · 2017Trial
- Folic acid ingestion improves skeletal muscle blood flow during graded handgrip and plantar flexion exercise in aged humans.American journal of physiology. Heart and circulatory physiology · 2017Trial
- Mast cell degranulation and de novo histamine formation contribute to sustained postexercise vasodilation in humans.Journal of applied physiology (Bethesda, Md. : 1985) · 2017Trial
- A single dose of histamine-receptor antagonists before downhill running alters markers of muscle damage and delayed-onset muscle soreness.Journal of applied physiology (Bethesda, Md. : 1985) · 2017Trial
- Evidence of a broad histamine footprint on the human exercise transcriptome.The Journal of physiology · 2016Trial
- Effect of antioxidants on histamine receptor activation and sustained postexercise vasodilatation in humans.Experimental physiology · 2015Trial
- Evidence of histamine release in response to both aerobic and resistance exercise: histamine metabolites as biomarkers.Journal of applied physiology (Bethesda, Md. : 1985) · 2026Article
- Ageing attenuates regional vasoconstriction during acute lowering of upper and lower limbs.Experimental physiology · 2026Article
- Home-based heat therapy lowers blood pressure and improves endothelial function in older adults.Journal of applied physiology (Bethesda, Md. : 1985) · 2025Article
- Effect of acute heat exposure on the pressor response to a voluntary hypoxic apnea.Journal of applied physiology (Bethesda, Md. : 1985) · 2023Article
- Isolated knee extensor exercise training improves skeletal muscle vasodilation, blood flow, and functional capacity in patients with HFpEF.Physiological reports · 2022Article
- Acute heat exposure protects against endothelial ischemia-reperfusion injury in aged humans.American journal of physiology. Regulatory, integrative and comparative physiology · 2022Article
- Shear stress induced by acute heat exposure is not obligatory to protect against endothelial ischemia-reperfusion injury in humans.Journal of applied physiology (Bethesda, Md. : 1985) · 2022Article
- Influence of ischemia-reperfusion injury on endothelial function in men and women with similar serum estradiol concentrations.American journal of physiology. Regulatory, integrative and comparative physiology · 2021Article
- Effect of endoplasmic reticulum stress on endothelial ischemia-reperfusion injury in humans.American journal of physiology. Regulatory, integrative and comparative physiology · 2020Article
- Exercise Training Improves Microvascular Function in Burn Injury Survivors.Medicine and science in sports and exercise · 2020Article
- Neural control of blood pressure is altered following isolated leg heating in aged humans.American journal of physiology. Heart and circulatory physiology · 2020Article
- Assessment of resistance vessel function in human skeletal muscle: guidelines for experimental design, Doppler ultrasound, and pharmacology.American journal of physiology. Heart and circulatory physiology · 2020Review
- Acute lower leg hot water immersion protects macrovascular dilator function following ischaemia-reperfusion injury in humans.Experimental physiology · 2020Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
It has been predicted that the development of thin-beam ultrasound could lead to an overestimation of mean blood velocity by up to 33% as beam width approaches 0% of vessel diameter. If both beam and vessel widths are known, in theory, this overestimation may be correctable. Therefore, we updated a method for determining the beam width of a Doppler ultrasound system, tested the utility of this technique and the information it provides to reliably correct for the error in velocity measurements, and explored how error-corrected velocity estimates impact the interpretation of in vivo data. Using a string phantom, we found the average beam width of four different probes varied across probes from 2.93 ± 0.05 to 4.41 ± 0.06 mm (mean ± SD) and with depth of insonation. Using this information, we tested the validity of a calculated correction factor to minimize the thin-beam error in mean velocity observed in a flow phantom with known diameter. Use of a correction factor reduced the overestimation from 39 ± 11 to 7 ± 9% (P < 0.05). Lastly, in vivo we explored how knowledge of beam width improves understanding of physiological flow conditions. In vivo, use of a correction factor reduced the overestimation of mean velocity from 23 ± 11 to -4 ± 9% (P < 0.05). Thus this large source of error is real, has been largely ignored by the early adaptors of Doppler ultrasound for vascular physiology studies in humans, and is correctable by the described techniques.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.