ArticleIEEE transactions on bio-medical engineering2014
An efficient finite element approach for modeling fibrotic clefts in the heart.
Article in IEEE transactions on bio-medical engineering, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed.
- Models of cardiomyocyte-non-myocyte electrical interactions.The Journal of physiology · 2026Review
- An efficient end-to-end computational framework for the generation of ECG calibrated volumetric models of human atrial electrophysiology.Medical image analysis · 2026Article
- Re-entry in models of cardiac ventricular tissue with scar represented as a Gaussian random field.Frontiers in physiology · 2024Article
- Fibrosis modeling choice affects morphology of ventricular arrhythmia in non-ischemic cardiomyopathy.Frontiers in physiology · 2024Article
- Homogenisation for the monodomain model in the presence of microscopic fibrotic structures.Communications in nonlinear science & numerical simulation · 2023Article
- The physics of heart rhythm disorders.Physics reports · 2022Article
- An automated near-real time computational method for induction and treatment of scar-related ventricular tachycardias.Medical image analysis · 2022Article
- Predicting Atrial Fibrillation Recurrence by Combining Population Data and Virtual Cohorts of Patient-Specific Left Atrial Models.Circulation. Arrhythmia and electrophysiology · 2022Article
- It's clearly the heart! Optical transparency, cardiac tissue imaging, and computer modelling.Progress in biophysics and molecular biology · 2022Article
- A personalized real-time virtual model of whole heart electrophysiology.Frontiers in physiology · 2022Article
- A Review of Healthy and Fibrotic Myocardium Microstructure Modeling and Corresponding Intracardiac Electrograms.Frontiers in physiology · 2022Review
- Etiology-Specific Remodeling in Ventricular Tissue of Heart Failure Patients and Its Implications for Computational Modeling of Electrical Conduction.Frontiers in physiology · 2021Article
- 3D Electrophysiological Modeling of Interstitial Fibrosis Networks and Their Role in Ventricular Arrhythmias in Non-Ischemic Cardiomyopathy.IEEE transactions on bio-medical engineering · 2020Article
- Identifying locations of re-entrant drivers from patient-specific distribution of fibrosis in the left atrium.PLoS computational biology · 2020Article
- Anisotropic conduction in the myocardium due to fibrosis: the effect of texture on wave propagation.Scientific reports · 2020Article
- Factors Promoting Conduction Slowing as Substrates for Block and Reentry in Infarcted Hearts.Biophysical journal · 2019Article
- Scar shape analysis and simulated electrical instabilities in a non-ischemic dilated cardiomyopathy patient cohort.PLoS computational biology · 2019Article
- Acetylcholine Delays Atrial Activation to Facilitate Atrial Fibrillation.Frontiers in physiology · 2019Article
- Extended Bidomain Modeling of Defibrillation: Quantifying Virtual Electrode Strengths in Fibrotic Myocardium.Frontiers in physiology · 2019Article
- Variability in pulmonary vein electrophysiology and fibrosis determines arrhythmia susceptibility and dynamics.PLoS computational biology · 2018Article
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Authors and funding
8 authors.
Funding
Abstract
Advanced medical imaging technologies provide a wealth of information on cardiac anatomy and structure at a paracellular resolution, allowing to identify microstructural discontinuities which disrupt the intracellular matrix. Current state-of-the-art computer models built upon such datasets account for increasingly finer anatomical details, however, structural discontinuities at the paracellular level are typically discarded in the model generation process, owing to the significant costs which incur when using high resolutions for explicit representation. In this study, a novel discontinuous finite element (dFE) approach for discretizing the bidomain equations is presented, which accounts for fine-scale structures in a computer model without the need to increase spatial resolution. In the dFE method, this is achieved by imposing infinitely thin lines of electrical insulation along edges of finite elements which approximate the geometry of discontinuities in the intracellular matrix. Simulation results demonstrate that the dFE approach accounts for effects induced by microscopic size scale discontinuities, such as the formation of microscopic virtual electrodes, with vast computational savings as compared to high resolution continuous finite element models. Moreover, the method can be implemented in any standard continuous finite element code with minor effort.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.