ArticleDigestive diseases and sciences2014
Outcomes of liver transplantation for porto-pulmonary hypertension in model for end-stage liver disease era.
Article in Digestive diseases and sciences, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
13 citing papers in PubMed, 1 synthesis or guideline pooled it, 34 citations in OpenAlex.
- The early outcomes of candidates with portopulmonary hypertension after liver transplantation.BMC gastroenterology · 2018Pooled it
- Emergency ECMO Deployment During Liver Transplantation in Portopulmonary Hypertension Patients.The American journal of case reports · 2025Article
- Hemodynamic and Clinical Response to Liver Transplantation in Children and Young Adults POPH Patients.Pediatric cardiology · 2024Article
- Portopulmonary Hypertension: An Updated Review.Transplantation direct · 2023Review
- Current Approaches in the Allocation of Liver Transplantation.Journal of personalized medicine · 2022Review
- Portopulmonary hypertension: Current developments and future perspectives.Liver research (Beijing, China) · 2022Review
- Preoperative 2D-echocardiographic assessment of pulmonary arterial pressure in subgroups of liver transplantation recipients.Anesthesia and pain medicine · 2021Article
- Prevalence and Associated Factors of Portopulmonary Hypertension in Patients with Portal Hypertension: A Case-Control Study.BioMed research international · 2021Article
- Living Donor Liver Transplantation in Biliary Atresia Children with Pulmonary Hypertension.International journal of medical sciences · 2019Article
- Correlation between Echocardiographic Pulmonary Artery Pressure Estimates and Right Heart Catheterization Measurement in Liver Transplant Candidates.Journal of cardiovascular imaging · 2018Article
- Predictors of Waitlist Mortality in Portopulmonary Hypertension.Transplantation · 2017Article
- Current Approach to the Diagnosis and Management of Portopulmonary Hypertension.Current gastroenterology reports · 2016Review
- The Intersection of Pulmonary Hypertension and Solid Organ Transplantation.Methodist DeBakey cardiovascular journalReview
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
Abstract
unlabelledPorto-pulmonary hypertension (POPH), once considered an absolute contraindication for liver transplantation (LT), has become a more accepted indication because of the evolution of treatment with prostacyclin analogues, phosphodiesterase inhibitors and endothelin receptor antagonists. An exception model for end stage liver disease (MELD) score of 22 is assigned to candidates with documentation of effective treatment. We examined the post-transplant outcomes of patients who received LT for POPH with exception.
methodsScientific Registry of Transplant Recipients data on 34,318 adult (≥ 18 years) deceased donor LT recipients transplanted between March 1, 2002 and August 31, 2010 were reviewed. The diagnosis of POPH was ascertained from MELD exception forms. Patients were followed from the time of transplant until the earlier occurrence of death or end of the follow-up period. Cox regression was used to evaluate the predictors of post-LT mortality and graft failure.
resultsDuring the study period, 34,318 patients received deceased donor LT. Seventy eight out of 34,318 patients were transplanted for POPH with MELD exception. The 1-year adjusted risks of patient death and graft failure for patients transplanted under exception rules for POPH were significantly higher than with POPH adult recipients who did not receive exception points (death:hazard ratio [HR] = 2.25, p = 0.005 and graft failure HR = 1.96, p = 0.012).
conclusionsThis study of national data suggests that treated POPH continues to be associated with inferior early post-transplant outcomes.
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