ArticleEuropean archives of psychiatry and clinical neuroscience2014
Increased neural activity during overt and continuous semantic verbal fluency in major depression: mainly a failure to deactivate.
Article in European archives of psychiatry and clinical neuroscience, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- The role of rumination and racing thoughts in co-occurrence of ADHD symptoms, depression and anxiety symptoms.Australian journal of psychology · 2026Article
- Depression Symptoms Moderate Associations between Daily Functioning and Neuropsychological Performance in Mexican American Adults.Archives of clinical neuropsychology : the official journal of the National Academy of Neuropsychologists · 2025Article
- Cortical network characteristics in post-stroke anxiety: an fNIRS-based study.Frontiers in neuroscience · 2025Article
- Abnormal structural covariance network in major depressive disorder: Evidence from the REST-meta-MDD project.NeuroImage. Clinical · 2025Article
- Subregions of the fusiform gyrus are differentially involved in the attentional mechanism supporting visual mental imagery in depression.Brain imaging and behavior · 2024Article
- Plasma Amyloid-β dynamics in late-life major depression: a longitudinal study.Translational psychiatry · 2022Article
- Impairments of Social Interaction in Depressive Disorder.Psychiatry investigation · 2022Article
- Clinical Response of Major Depressive Disorder Patients With Suicidal Ideation to Individual Target-Transcranial Magnetic Stimulation.Frontiers in psychiatry · 2021Article
- Impaired naming performance in temporal lobe epilepsy: language fMRI responses are modulated by disease characteristics.Journal of neurology · 2021Article
- Greater Dynamic and Lower Static Functional Brain Connectivity Prospectively Predict Placebo Response in Pediatric Generalized Anxiety Disorder.Journal of child and adolescent psychopharmacology · 2020Article
- Default mode network deactivation during emotion processing predicts early antidepressant response.Translational psychiatry · 2017Article
- An examination of the language construct in NIMH's research domain criteria: Time for reconceptualization!American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics · 2016Review
- Disrupted Interhemispheric Synchrony in Default Mode Network Underlying the Impairment of Cognitive Flexibility in Late-Onset Depression.Frontiers in aging neuroscience · 2016Article
- A genome-wide supported psychiatric risk variant in NCAN influences brain function and cognitive performance in healthy subjects.Human brain mapping · 2015Article
- Suicide ideation, stability of symptoms and effects of aerobic exercise in major depression.European archives of psychiatry and clinical neuroscience · 2014Article
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Authors and funding
7 authors.
Funding
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Abstract
Major depression is associated with impairments in semantic verbal fluency (VF). However, the neural correlates underlying dysfunctional cognitive processing in depressed subjects during the production of semantic category members still remain unclear. In the current study, an overt and continuous semantic VF paradigm was used to examine these mechanisms in a representative sample of 33 patients diagnosed with a current episode of unipolar depression and 33 statistically matched healthy controls. Subjects articulated words in response to semantic category cues while brain activity was measured with functional magnetic resonance imaging (fMRI). Compared to controls, patients showed poorer task performance. On the neural level, a group by condition interaction analysis, corrected for task performance, revealed a reduced task-related deactivation in patients in the right parahippocampal gyrus, the right fusiform gyrus, and the right supplementary motor area. An additional and an increased task-related activation in patients were observed in the right precentral gyrus and the left cerebellum, respectively. These results indicate that a failure to suppress potentially interfering activity from inferior temporal regions involved in default-mode network functions and visual imagery, accompanied by an enhanced recruitment of areas implicated in speech initiation and higher-order language processes, may underlie dysfunctional cognitive processing during semantic VF in depression. The finding that patients with depression demonstrated both decreased performance and aberrant brain activation during the current semantic VF task demonstrates that this paradigm is a sensitive tool for assessing brain dysfunctions in clinical populations.
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