ArticleNature communications2014
African origin of the malaria parasite Plasmodium vivax.
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Article in Nature communications, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 131 papers, 2 of them syntheses that pooled it.
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131citing papers in PubMed, 2 pooled it
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Who cites it
131 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Plasmodium vivax epidemiology in Ethiopia 2000-2020: A systematic review and meta-analysis.PLoS neglected tropical diseases · 2021Pooled it
- A review of wildlife tourism and meta-analysis of parasitism in Africa's national parks and game reserves.Parasitology research · 2018Pooled it
- In vivo efficacy of chloroquine plus primaquine combination therapy against uncomplicated Plasmodium vivax malaria in Limu Kossa District, Jimma Zone, Southwest Ethiopia.Malaria journal · 2024Trial
- Targeted chromosomal sequencing of wild bonobos identifies a genetically distinct subpopulation east of the Lomami river.Genome biology · 2026Article
- Hidden hematological, biochemical and immune costs of asymptomatic malaria infections in semi-wild chimpanzees.PLoS pathogens · 2026Article
- Invasion preferences suggest a possible role for Plasmodium falciparum parasites in the expansion of Duffy negativity in West and Central Africa.Molecular biology and evolution · 2026Article
- Sudan's complex genetic admixture history drives adaptation to malaria in Sudanese Copts.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Targeted Chromosomal Sequencing of Wild Bonobos Identifies a Genetically Distinct Subpopulation East of the Lomami River.bioRxiv : the preprint server for biology · 2026Article
- A divergent hepatitis A virus lineage in wild western lowland gorillas and central chimpanzees supports localized circulation and expands HAV diversity.Virus evolution · 2026Article
- Multi-centric origins and gene flow shape the diversity of β-thalassemia mutations in Southern East Asia.Nature communications · 2025Article
- Hidden hematological, biochemical and immune costs of asymptomatic malaria infections in semi-wild chimpanzees.bioRxiv : the preprint server for biology · 2025Article
- Combined effect of methanolic extracts ofParasite epidemiology and control · 2025Article
- Trend of malaria parasites infection in Ethiopia along an international border: a Bayesian spatio-temporal study.Infectious diseases of poverty · 2025Article
- Prevalence of molecular markers associated withThe Pan African medical journal · 2025Article
- Remarkable Evolutionary Rate Variations Among Lineages and Among Genome Compartments in Malaria Parasites of Mammals.Molecular biology and evolution · 2024Article
- Loop-Mediated Isothermal Amplification for Diagnosis of Zoonotic Malaria.The American journal of tropical medicine and hygiene · 2024Article
- Origin of the human malaria parasite Plasmodium vivax.Trends in parasitology · 2024Review
- Article
- Genetic differentiation of Plasmodium vivax duffy binding protein in Ethiopia and comparison with other geographical isolates.Malaria journal · 2024Article
- The Genome of Plasmodium gonderi: Insights into the Evolution of Human Malaria Parasites.Genome biology and evolution · 2024Article
71 more citing papers are in PubMed but not listed here.
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Authors and funding
56 authors.
Weimin LiuDepartment of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA.
Yingying LiDepartment of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA.
Katharina S ShawDepartment of Biological Sciences, Columbia University, New York, New York 10027, USA.
Gerald H LearnDepartment of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA.
Lindsey J PlenderleithInstitute of Evolutionary Biology, University of Edinburgh, Edinburgh EH9 3JT, UK.
Jordan A MalenkeDepartment of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA.
Sesh A Sundararaman1] Department of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA [2] Department of Microbiology, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA.
Miguel A RamirezDepartment of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA.
Patricia A CrystalDepartment of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA.
Andrew G SmithDepartment of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA.
Frederic Bibollet-RucheDepartment of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA.
Ahidjo AyoubaUnité Mixte Internationale 233 Institut de Recherche pour le Développement and University of Montpellier 1, 34394 Montpellier, France.
Sabrina LocatelliUnité Mixte Internationale 233 Institut de Recherche pour le Développement and University of Montpellier 1, 34394 Montpellier, France.
Amandine EstebanUnité Mixte Internationale 233 Institut de Recherche pour le Développement and University of Montpellier 1, 34394 Montpellier, France.
Fatima MouachaUnité Mixte Internationale 233 Institut de Recherche pour le Développement and University of Montpellier 1, 34394 Montpellier, France.
Emilande GuichetUnité Mixte Internationale 233 Institut de Recherche pour le Développement and University of Montpellier 1, 34394 Montpellier, France.
Christelle ButelUnité Mixte Internationale 233 Institut de Recherche pour le Développement and University of Montpellier 1, 34394 Montpellier, France.
Steve Ahuka-Mundeke1] Unité Mixte Internationale 233 Institut de Recherche pour le Développement and University of Montpellier 1, 34394 Montpellier, France [2] Institut National de Recherche Biomedicale, BP 1197 Kinshasa, Democratic Republic of the Congo.
Bila-Isia InogwabiniDepartment of Aquatic Sciences and Assessment, Swedish University of Agricultural Sciences, SE-75007 Uppsala, Sweden.
Jean-Bosco N NdjangoDepartment of Ecology and Management of Plant and Animal Resources, Faculty of Sciences, University of Kisangani, BP 2012 Kisangani, Democratic Republic of the Congo.
Sheri SpeedeSanaga-Yong Chimpanzee Rescue Center, IDA-Africa, Portland, Oregon 97204, USA.
Crickette M Sanz1] Department of Anthropology, Washington University, St Louis, Missouri 63130, USA [2] Wildlife Conservation Society, Congo Program, BP 14537 Brazzaville, Republic of the Congo.
David B Morgan1] Wildlife Conservation Society, Congo Program, BP 14537 Brazzaville, Republic of the Congo [2] Lester E. Fisher Center for the Study and Conservation of Apes, Lincoln Park Zoo, Chicago, Illinois 60614, USA.
Mary K GonderDepartment of Biological Sciences, University at Albany, State University of New York, Albany, New York 12222, USA.
Philip J KranzuschDepartment of Molecular and Cell Biology, University of California, Berkeley, California 94720, USA.
Peter D WalshDivision of Biological Anthropology, University of Cambridge, Cambridge CB2 1QH, UK.
Alexander V Georgiev1] Department of Human Evolutionary Biology, Harvard University, Boston, Massachusetts 02115, USA [2].
Martin N MullerDepartment of Anthropology, University of New Mexico, Albuquerque, New Mexico 87131, USA.
Alex K Piel1] Division of Biological Anthropology, University of Cambridge, Cambridge CB2 1QH, UK [2] Department of Anthropology, University of California, San Diego, California 92093, USA.
Fiona A StewartDivision of Biological Anthropology, University of Cambridge, Cambridge CB2 1QH, UK.
Michael L WilsonDepartment of Anthropology, University of Minnesota, Minneapolis, Minnesota 55455, USA.
Anne E PuseyDepartment of Evolutionary Anthropology, Duke University, Durham, North Carolina 27708, USA.
Liwang CuiDepartment of Entomology, Pennsylvania State University, University Park, Pennsylvania 16802, USA.
Zenglei WangDepartment of Entomology, Pennsylvania State University, University Park, Pennsylvania 16802, USA.
Anna FärnertInfectious Disease Unit, Karolinska Institute, Department of Medicine Solna, Karolinska University Hospital, Stockholm SE-17176, Sweden.
Colin J SutherlandPublic Health England Malaria Reference Laboratory, Faculty of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London WC1E 7HT, UK.
Debbie NolderPublic Health England Malaria Reference Laboratory, Faculty of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London WC1E 7HT, UK.
John A HartLukuru Wildlife Research Foundation, Tshuapa-Lomami-Lualaba Project, BP 2012 Kinshasa, Democratic Republic of the Congo.
Terese B HartLukuru Wildlife Research Foundation, Tshuapa-Lomami-Lualaba Project, BP 2012 Kinshasa, Democratic Republic of the Congo.
Paco BertolaniLeverhulme Centre for Human Evolutionary Studies, University of Cambridge, Cambridge, CB2 1QH, UK.
Amethyst GillisGlobal Viral Forecasting Initiative, San Francisco, California 94104, USA.
Matthew LeBretonGlobal Viral Forecasting Initiative, San Francisco, California 94104, USA.
Babila TafonApe Action Africa, BP 20072 Yaounde, Cameroon.
John KiyangLimbe Wildlife Centre, PO Box 878 Limbe, Cameroon.
Cyrille F DjokoGlobal Viral Forecasting Initiative, San Francisco, California 94104, USA.
Bradley S SchneiderGlobal Viral Forecasting Initiative, San Francisco, California 94104, USA.
Nathan D WolfeGlobal Viral Forecasting Initiative, San Francisco, California 94104, USA.
Eitel Mpoudi-NgoleInstitut de Recherches Médicales et d'Études des Plantes Médicinales Prévention du Sida au Cameroun, Centre de Recherche Médicale, BP 906 Yaoundé, Republic of Cameroon.
Eric DelaporteUnité Mixte Internationale 233 Institut de Recherche pour le Développement and University of Montpellier 1, 34394 Montpellier, France.
Richard Carter1] Institute of Immunology and Infection Research, University of Edinburgh, Edinburgh EH9 3JT, UK [2] Centre for Immunity, Infection and Evolution, University of Edinburgh, Edinburgh EH9 3JT, UK.
Richard L CulletonMalaria Unit, Institute of Tropical Medicine, Nagasaki University, Nagasaki 852-8523, Japan.
George M Shaw1] Department of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA [2] Department of Microbiology, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA.
Julian C RaynerMalaria Programme, Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SA, UK.
Martine PeetersUnité Mixte Internationale 233 Institut de Recherche pour le Développement and University of Montpellier 1, 34394 Montpellier, France.
Beatrice H Hahn1] Department of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA [2] Department of Microbiology, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA.
Paul M Sharp1] Institute of Evolutionary Biology, University of Edinburgh, Edinburgh EH9 3JT, UK [2] Centre for Immunity, Infection and Evolution, University of Edinburgh, Edinburgh EH9 3JT, UK.
Funding
Virus & Reservoirs CoreP30AI045008 · NIAID · UNIVERSITY OF PENNSYLVANIA · PI ROBERT GROSS · 1999 to 2026
$78.6MMolecular Epidemiology and Natural History of SIVcpzR01AI058715 · NIAID · UNIVERSITY OF PENNSYLVANIA · PI HAHN, BEATRICE H · 2004 to 2013
$6.1MNatural SIV Reservoirs and Human Zoonotic RiskR37AI050529 · NIAID · UNIVERSITY OF PENNSYLVANIA · PI HAHN, BEATRICE H · 2008 to 2017
$5.7MGreat Ape Reservoirs of Human MalariaR01AI091595 · NIAID · UNIVERSITY OF PENNSYLVANIA · PI HAHN, BEATRICE H · 2011 to 2019
$5.3MPARASITOLOGY: MODERN APPROACHEST32AI007532 · NIAID · UNIVERSITY OF PENNSYLVANIA · PI HERBERT, DE'BROSKI R · 1998 to 2022
$5.0MMedical Research Council MR/L008661/1NIAID NIH HHS P30 AI045008NIAID NIH HHS R01 AI058715NIAID NIH HHS R01 AI091595NIAID NIH HHS R01 AI58715NIAID NIH HHS R37 AI050529NIAID NIH HHS T32 AI007532Wellcome Trust 095831Wellcome Trust 098051
Abstract
Plasmodium vivax is the leading cause of human malaria in Asia and Latin America but is absent from most of central Africa due to the near fixation of a mutation that inhibits the expression of its receptor, the Duffy antigen, on human erythrocytes. The emergence of this protective allele is not understood because P. vivax is believed to have originated in Asia. Here we show, using a non-invasive approach, that wild chimpanzees and gorillas throughout central Africa are endemically infected with parasites that are closely related to human P. vivax. Sequence analyses reveal that ape parasites lack host specificity and are much more diverse than human parasites, which form a monophyletic lineage within the ape parasite radiation. These findings indicate that human P. vivax is of African origin and likely selected for the Duffy-negative mutation. All extant human P. vivax parasites are derived from a single ancestor that escaped out of Africa.
Indexed as
AfricaAnimalsAsiaEvolution, MolecularMalariaPhylogenyPlasmodium vivax
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